A validated clinical tool for the prediction of varices in PBC: The Newcastle Varices in PBC Score

Stratification of hepatocellular carcinoma risk in primary biliary cirrhosis: a multicentre international study

“…Indeed, on multivariable analysis only thrombocytopenia and biochemical non-response retained statistical significance and superseded the effect of gender and other tested parameters of disease stage. Of interest, platelet count is commonly employed as a surrogate of portal hypertension,35 and as part of the AST/platelet ratio has recently been validated as an independent and additive biomarker of transplant-free survival in biochemical responders 3. However, given the relatively small number of HCC observed in responding patients, sub-stratification of cancer risk in such regard would prove difficult.…”

Geoepidemiology and changing mortality in primary biliary cholangitis

“…An enormous effort has been made to define the genetics and immuobiology of human autoimmue liver diseases in both human and mouse models [59][60][61][62][63][64][65][66][67][68][69][70][71][72]. Yet there remains an enormous gap between these investigative efforts and clinical translation.…”

Insight into the natural history of primary biliary cirrhosis: A systemic review of data from placebo-controlled clinical trials

“…The development of portal hypertension, particularly gastroesophageal varices, has been identified as one of the factors for risk of death in PBC patients (32). Symptoms related to portal hypertension in PBC usually develop after the onset of cirrhosis but occasionally can be found in precirrhotic stages.…”