A validated LC–MS/MS assay for the simultaneous determination of periplocin and its two metabolites, periplocymarin and periplogenin in rat plasma: Application to a pharmacokinetic study

He, Jun; Fang, Bo; Tu, Yaru; Azietaku, John Teye; Dou, Ting; Ouyang, Hongwei; Chang, Yan‐xu; Hong, Liu; Gao, Xiumei

doi:10.1016/j.jpba.2015.06.008

Cited by 20 publications

(14 citation statements)

References 8 publications

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“…There is a report on the PK study of periplocin with its two metabolites (periplocymarin and periplogenin) in rat plasma and periplogenin in rat plasma. He et al [6] studied the PK of Cortex Periplocae in rat's serum. This was studied to determine the concentrations of periplocin and two metabolites simultaneously in rats' plasma by using LC-MS/MS.…”

Section: Pharmacokineticsmentioning

confidence: 99%

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A Review on Phytochemistry and Pharmacology of Cortex Periplocae

Yang

Zhou

et al. 2016

Molecules

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Cortex Periplocae, as a traditional Chinese herbal medicine, has been widely used for autoimmune diseases, especially rheumatoid arthritis. Due to its potential pharmaceutical values, more studies about the biological activities of Cortex Periplocae have been conducted recently. Meanwhile, the adverse reaction of Cortex Periplocae is not a negligible problem in clinic. In this article, we reviewed a series of articles and summarized the recent studies of Cortex Periplocae in the areas of phytochemistry and pharmacology. More than 100 constituents have been isolated and identified from Cortex Periplocae, including steroids, cardiac glycosides, terpenoids, and fatty acid compounds. The crude extracts of Cortex Periplocae and its active compounds exhibit various biological activities, such as cardiotonic effect, anticancer action, and anti-inflammatory effect. This paper aims to provide an overall review on the bioactive ingredients, pharmacological effect, and toxicity of this plant. Furthermore, this review suggests investigating and developing new clinical usages according to the above pharmacological effects.

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Section: Pharmacokineticsmentioning

confidence: 99%

“…Besides its characteristic antirheumatic effect, it was shown to specifically treat heart failure. Research studies showed that the extracts of Cortex Periplocae exhibited cardiotonic effects on the isolated heart of rats and could strengthen cardiotonic function [5,6]. In addition, more studies have been focused on its antitumoral effect.…”

Section: Introductionmentioning

confidence: 99%

A Review on Phytochemistry and Pharmacology of Cortex Periplocae

Yang

Zhou

et al. 2016

Molecules

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“…There is a report on the PK study of periplocin with its two metabolites (periplocymarin and periplogenin) in rat plasma and periplogeninin in rat plasma. He et al [6] studied the PK of Cortex Periplocae in rat's serum. This was studied to determine the concentrations of periplocin and two metabolites simultaneously in rats' plasma by using LC-MS/MS.…”

Section: Pharmacokineticsmentioning

confidence: 99%

“…Besides its characteristic antirheumatic effect, it was shown 2 of 16 to specifically treat heart failure. Research studies showed that the extracts of Cortex Periplocae exhibited cardiotonic effects on the isolated heart of rats and could strengthen cardiotonic function [5,6]. In addition, more studies have been focused on its antitumoral effect.…”

Section: Introductionmentioning

confidence: 99%

A Review on Phytochemistry and Pharmacology of <em>Cortex Periplocae</em>

Zhou

et al. 2016

Preprint

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Abstract:Cortex Periplocae, as a traditional Chinese herbal medicine, has been widely used for autoimmune diseases, especially rheumatoid arthritis. Due to its potential pharmaceutical values, more studies about the biological activities of Cortex Periplocae have been conducted recently. Meanwhile, the adverse reaction of Cortex Periplocae is not a negligible problem in clinic. In this article, we reviewed a series of articles and summarized the recent studies of Cortex Periplocae in the areas of phytochemistry and pharmacology. More than 100 constituents have been isolated and identified from Cortex Periplocae, including steroids, cardiac glycosides, terpenoids, and fatty acid compounds. The crude extracts of Cortex Periplocae and its active compounds exhibit various biological activities, such as cardiotonic effect, anticancer action, and anti-inflammatory effect. This paper aims to provide an overall review on the bioactive ingredients, pharmacological effect, and toxicity of this plant. Furthermore, this review suggests investigating and developing new clinical usages according to the above pharmacological effects.

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“…To the best of our knowledge, chemical profiling of components and their metabolites of Periplocae Cortex had not been performed and reported before. Recent studies focused on several compounds, such as periplocin, in the field of quality evaluation and pharmacokinetic research (Bo et al, ; He et al, ; Li, He, Li, & Zhou, ). Notably, the metabolism feature of C21 steroidal glycosides, an important group of chemical ingredients possessing various bioactivities in Periplocae Cortex, still remains unknown.…”

Section: Introductionmentioning

confidence: 99%

Characterization of chemical components of Periplocae Cortex and their metabolites in rats using ultra‐performance liquid chromatography coupled with quadrupole time‐of‐flight mass spectrometry

Zhang

Chen

et al. 2020

Biomedical Chromatography

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Periplocae Cortex, named Xiang‐Jia‐Pi in China, has been widely used to treat autoimmune diseases, especially rheumatoid arthritis. However, the in vivo substances of Periplocae Cortex remain unknown yet. In this study, an ultra‐performance liquid chromatography coupled with quadrupole time‐of‐flight mass spectrometry was used for profiling the chemical components and related metabolites of Periplocae Cortex. A total of 98 constituents were identified or tentatively characterized in Periplocae Cortex: 42 C21 steroidal glycosides, 10 cardiac glycosides, 23 organic acids, 4 aldehydes, 7 triterpenes, and 12 other types. Among them, 18 components were unambiguously identified by comparison with reference standards. In addition, 176 related xenobiotics (34 prototypes and 142 metabolites) were screened out and characterized in rats’ biosamples (plasma, urine, bile, and feces) after the oral administration of Periplocae Cortex. Moreover, the metabolic fate of periplocoside S‐4a, a C21 steroidal glycoside, was proposed for the first time. In summary, phase II reactions (methylation, glucuronidation, and sulfation), phase I reactions (hydrolysis reactions, oxygenation, and reduction), and their combinations were the predominant metabolic reactions of Periplocae Cortex in rat. It is the first report to reveal the in vivo substances and metabolism feature of Periplocae Cortex. This study also provided meaningful information for further pharmacodynamics study of Periplocae Cortex, as well as its quality control research.

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A validated LC–MS/MS assay for the simultaneous determination of periplocin and its two metabolites, periplocymarin and periplogenin in rat plasma: Application to a pharmacokinetic study

Cited by 20 publications

References 8 publications

A Review on Phytochemistry and Pharmacology of Cortex Periplocae

A Review on Phytochemistry and Pharmacology of Cortex Periplocae

A Review on Phytochemistry and Pharmacology of <em>Cortex Periplocae</em>

Characterization of chemical components of Periplocae Cortex and their metabolites in rats using ultra‐performance liquid chromatography coupled with quadrupole time‐of‐flight mass spectrometry

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