A validated liquid chromatography–tandem mass spectrometry method for the determination of methyl gallate and pentagalloyl glucopyranose: Application to pharmacokinetic studies

Jiamboonsri, Pimsumon; Pithayanukul, Pimolpan; Bavovada, Rapepol; Gao, Song; Hu, Ming

doi:10.1016/j.jchromb.2015.02.006

Cited by 25 publications

(17 citation statements)

References 26 publications

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“…Methyl gallate 1,3,6-Tri-O-galloyl-β-D-glucose Mean ± SD (μg/mL) RSD (%) RE (%) Mean ± SD (μg/mL) RSD (%) RE (%) Mean ± SD (μg/mL) RSD (%) RE (%) . In addition, some PK parameters of methyl gallate in this study were different from those in the literature reported (Jiamboonsri et al, 2015), and it could be explained by the difference in dosage, the administration method, and the interactions from complex constituents in the extract. As for gallic acid, part of its parameters were different from the results observed in the present study (Gao et al, 2014;Wang et al, 2008).…”

Section: Conditionscontrasting

confidence: 98%

“…Some HPLC-UV (Qin, Hu, & Zhang, 2011;Hou, Liang, & Lu, 2005;Li, Yang, Xiao, Du, & Wei, 2011) methods have been developed for the determination of gallic acid and methyl gallate, but most of these methods were developed for their quantitative determination in vitro, not in biological samples. According to the literature, several HPLC-UV methods (Huo, Peng, Gao, Zhou, & Aibai, 2011;Wu, 2014) and LC-MS/MS methods (Jiamboonsri, Pithayanukul, Bavovada, Gao, & Hu, 2015) exist to determine the levels of gallic acid or methyl gallate in rat serum. However, a compatible quantitative method for gallic acid, methyl gallate, and 1,3,6-tri-O-galloyl-β-D-glucose in biological samples has not been developed yet; most of the assays determine only one of them.…”

Section: Introductionmentioning

confidence: 99%

“…Previous studies have developed a reversed-phase HPLC method for the determination of gallic acid in rat serum with a lower limit of quantification (LLOQ) at 0.78 μg/mL, which was not sensitive enough to enable its study of PKs (Wu, 2014). In addition, some researchers have published an LC-MS/MS method for the determination of methyl gallate, which required complicated pretreatment procedures and had low sensitivity (LLOQ: 3.59 μg/mL) (Jiamboonsri et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

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Simultaneous determination of gallic acid, methyl gallate, and 1,3,6‐tri‐O‐galloyl‐β‐d‐glucose from Turkish galls in rat plasma using liquid chromatography‐tandem mass spectrometry and its application to pharmacokinetics study

Gong

Lin

et al. 2020

Biomedical Chromatography

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Turkish galls (TG) is a traditional Uygur medicine typically used in clinics for dental disease and chronic ulcerative colitis. In this study, a novel liquid chromatography‐tandem mass spectrometry method was developed and validated for the simultaneous quantification of gallic acid, methyl gallate, and 1,3,6‐tri‐O‐galloyl‐β‐d‐glucose in rat plasma, which are the major bioactive compounds of TG. After a feasible protein precipitation using acetonitrile for sample preparation, chromatographic separation was performed with a BDS Hypersil C18 column (2.1 × 100 mm, 5 μm) at 30°C, and water containing 10 mmol of ammonium acetate and acetonitrile was used as the mobile phase with a flow rate of 0.3 mL/min. The MS detector was operated in the selective reaction monitoring with negative‐ionization mode. The results of the method validation, including selectivity, linearity, accuracy, precision, extraction recovery, matrix effect, and stability of the compounds in the biosamples, were all within the current acceptance criteria. The established method was successfully applied to the pharmacokinetics study of three analytes in rats after an oral administration of TG extract and laid the foundation for studying the active components and mechanism of TG in vivo.

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Section: Conditionscontrasting

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Simultaneous determination of gallic acid, methyl gallate, and 1,3,6‐tri‐O‐galloyl‐β‐d‐glucose from Turkish galls in rat plasma using liquid chromatography‐tandem mass spectrometry and its application to pharmacokinetics study

Gong

Lin

et al. 2020

Biomedical Chromatography

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“…A previous study showed that the maximum plasma concentration after intraperitoneal administration of 20 mg/kg of MG is 6.4 μg/mL [24]. However, this concentration is much smaller than the MIC of MG against Salmonella Typhimurium.…”

Section: Plos Onementioning

confidence: 92%

“…On the other hand, the PK of MAR has been reported in several previous studies. Another study presented the PK of MG in rats [24]. However, no previous study has been available on the effect of MG on the PK of MAR.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the pharmacokinetic-pharmacodynamic integration of marbofloxacin in combination with methyl gallate against Salmonella Typhimurium in rats

2020

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Fluoroquinolone resistance in Salmonella Typhimurium is becoming a major concern. Hence, an intervention to limit the growth in resistance is inevitable. One way to combat this challenge is through combination therapy. The combination of antibiotics with phytochemicals has become an ideal means of preventing antimicrobial resistance. Recently, in an in vitro study, the combination of methyl gallate (MG) with marbofloxacin (MAR) has shown to prevent Salmonella Typhimurium invasion. It is also worth to study the effects of plant extracts on the pharmacokinetics of antibiotics. Hence, the objective of this study was to determine the effect of MG on the pharmacokinetics of MAR and pharmacokinetics/pharmacodynamics integration of MG and MAR. The micro-broth dilution method was used to obtain the minimum inhibitory concentration (MIC), and fractional inhibitory concentration (FIC) of MAR and MG. Whereas, the pharmacokinetic was conducted in rats by administering either MAR alone or combined with MG through oral and/or intravenous routes. The results indicated that the MIC of MAR and MG against standard strain Salmonella Typhimurium (ATCC 14028) was 0.031 and 500 μg/mL, respectively. The FIC index of the combination of MAR and MG was 0.5. For orally administered drugs, the C max and AUC 24h of MAR were 1.04 and 0.78 μg/mL and 5.98 and 6.11 h.μg/mL when MAR was given alone and in combination with MG, respectively. The intravenous administration of MAR showed a half-life of 3.8 and 3.9 h; a clearance rate of 1.1 and 0.73 L/h/kg and a volume of distribution of 5.98 and 4.13 L/kg for MAR alone and in combination with MG, respectively. The AUC 24 /MIC for MAR alone and in combination with MG was 192.8 and 381.9 h, respectively. In conclusion, MG has shown to increase the antimicrobial activity of MAR in vitro and ex vivo experiments without affecting the pharmacokinetics of MAR in rats.

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Dual‐Drug Nanomedicine Assembly with Synergistic Anti‐Aneurysmal Effects via Inflammation Suppression and Extracellular Matrix Stabilization

Zu,

Zhuang,

Peng

et al. 2024

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Abdominal aortic aneurysm (AAA) represents a critical cardiovascular condition characterized by localized dilation of the abdominal aorta, carrying a significant risk of rupture and mortality. Current treatment options are limited, necessitating novel therapeutic approaches. This study investigates the potential of a pioneering nanodrug delivery system, RAP@PFB, in mitigating AAA progression. RAP@PFB integrates pentagalloyl glucose (PGG) and rapamycin (RAP) within a metal–organic‐framework (MOF) structure through a facile assembly process, ensuring remarkable drug loading capacity and colloidal stability. The synergistic effects of PGG, a polyphenolic antioxidant, and RAP, an mTOR inhibitor, collectively regulate key players in AAA pathogenesis, such as macrophages and smooth muscle cells (SMCs). In macrophages, RAP@PFB efficiently scavenges various free radicals, suppresses inflammation, and promotes M1‐to‐M2 phenotype repolarization. In SMCs, it inhibits apoptosis and calcification, thereby stabilizing the extracellular matrix and reducing the risk of AAA rupture. Administered intravenously, RAP@PFB exhibits effective accumulation at the AAA site, demonstrating robust efficacy in reducing AAA progression through multiple mechanisms. Moreover, RAP@PFB demonstrates favorable biosafety profiles, supporting its potential translation into clinical applications for AAA therapy.

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A validated liquid chromatography–tandem mass spectrometry method for the determination of methyl gallate and pentagalloyl glucopyranose: Application to pharmacokinetic studies

Cited by 25 publications

References 26 publications

Simultaneous determination of gallic acid, methyl gallate, and 1,3,6‐tri‐O‐galloyl‐β‐d‐glucose from Turkish galls in rat plasma using liquid chromatography‐tandem mass spectrometry and its application to pharmacokinetics study

Simultaneous determination of gallic acid, methyl gallate, and 1,3,6‐tri‐O‐galloyl‐β‐d‐glucose from Turkish galls in rat plasma using liquid chromatography‐tandem mass spectrometry and its application to pharmacokinetics study

Evaluation of the pharmacokinetic-pharmacodynamic integration of marbofloxacin in combination with methyl gallate against Salmonella Typhimurium in rats

Dual‐Drug Nanomedicine Assembly with Synergistic Anti‐Aneurysmal Effects via Inflammation Suppression and Extracellular Matrix Stabilization

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