A versatile chitosan/ZnO nanocomposite with enhanced antimicrobial properties

Malini, Madasamy; Thirumavalavan, Munusamy; Yang, Weihong; Lee, Jiunn‐Fwu; Annadurai, G.

doi:10.1016/j.ijbiomac.2015.06.036

Cited by 108 publications

(39 citation statements)

References 41 publications

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“…Besides, ZnO was shown to be a better antibacterial agent compared to the highly studied titanium dioxide (TiO2) [24]. Consequently, there are several studies related to the antimicrobial activity of ZnO produced by different methods [25][26][27][28] and in its pure form, with different structures [29], in composites with other materials [30], and doped with other elements (e.g. silver) [31].…”

Section: Introductionmentioning

confidence: 99%

Antifungal activity of ZnO thin films prepared by glancing angle deposition

et al. 2019

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Highlights• Zinc Oxide thin films were deposited by reactive magnetron sputtering;• Inclined columns changed the thin films' surface porosity;• Sputtering incidence angle affects microstructure and antifungal properties;• Mesoporous thin films improved the antifungal properties against Candida albicans; ABSTRACTThin films of zinc oxide (ZnO) were produced by reactive DC magnetron sputtering with sputtering angles of α = 0º, 40º, 60º and 80º (glancing angle deposition configuration), aiming to be tested against the opportunist pathogenic fungus Candida albicans. The results showed the formation of stoichiometric ZnO thin films, with inclined columns for incidence angles equal to or more than 40º. All thin films presented high transparency in the visible range above the bandgap region (near 380 nm). The deposition conditions gave rise to a three-fold increase of the surface porosity with the increment of the incidence angle. Noteworthy, is the formation of different types of pores distributions, from micro-, through meso-, to macropores. Regarding the biological effect, the thin films produced with inclined columns presented a significant antifungal activity, with the inhibition of viable cell growth by 68 %. Moreover, the formation of mesoporous films enhanced the antifungal properties of ZnO thin films against Candida albicans. The overall behaviour indicates that these thin films are promising candidates to be applied in antimicrobial surfaces, as well as to be used in further studies to determine the molecular mechanisms involved in the antimicrobial action of ZnO.3

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Section: Introductionmentioning

confidence: 99%

Antifungal activity of ZnO thin films prepared by glancing angle deposition

et al. 2019

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“…Numerous investigations have reported a broad spectrum of ZnONPs bactericide in most G− and G+ bacteria such as E. coli, Salmonella enteritidis (S. enteritidis), S. typhimurium, Proteus vulgaris (P. vulgaris), Klebsiella pneumonia (K. pneumoniae), S. pyogenes, Aeromonas hydrophila (A. hydrophila), B. subtilis, S. aureus, L. monocytogenes, P. aeruginosa, Enterococcus faecalis (E. faecalis), Sarcina lutea (S. lutea), and more [35][36][37][38][39][40].The combined use of such organic-inorganic substances can offer several advantages in the development of novel active materials. For instance, a good dispersion of ZnONPs in an EO-containing PHA matrix can be effectively achieved and the properties of the resultant composite are improved [41]. From a chemical point of view, the integration of MNPs in polymers can be attained by a stable incrustation of the nanoparticles in the polymer matrix without having any chemical interaction or an anchorage of the nanoparticles on the surface by means of covalent, ionic, or hydrogen bonds [42].…”

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confidence: 99%

“…The combined use of such organic-inorganic substances can offer several advantages in the development of novel active materials. For instance, a good dispersion of ZnONPs in an EO-containing PHA matrix can be effectively achieved and the properties of the resultant composite are improved [41]. From a chemical point of view, the integration of MNPs in polymers can be attained by a stable incrustation of the nanoparticles in the polymer matrix without having any chemical interaction or an anchorage of the nanoparticles on the surface by means of covalent, ionic, or hydrogen bonds [42].…”

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confidence: 99%

Electrospun Active Biopapers of Food Waste Derived Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) with Short-Term and Long-Term Antimicrobial Performance

et al. 2020

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This research reports about the development by electrospinning of fiber-based films made of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) derived from fermented fruit waste, so-called bio-papers, with enhanced antimicrobial performance. To this end, different combinations of oregano essential oil (OEO) and zinc oxide nanoparticles (ZnONPs) were added to PHBV solutions and electrospun into mats that were, thereafter, converted into homogeneous and continuous films of 130 µm. The morphology, optical, thermal, mechanical properties, crystallinity, and migration into food simulants of the resultant PHBV-based bio-papers were evaluated and their antimicrobial properties were assessed against Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) in both open and closed systems. It was observed that the antimicrobial activity decreased after 15 days due to the release of the volatile compounds, whereas the bio-papers filled with ZnONPs showed high antimicrobial activity for up to 48 days. The electrospun PHBV biopapers containing 2.5 wt% OEO + 2.25 wt% ZnONPs successfully provided the most optimal activity for short and long periods against both bacteria. Nanomaterials 2020, 10, 506 2 of 26 studied, including the poly(3-hydroxybutyrate) (PHB or P3HB) homopolyester and its copolymer poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV). The latter shows lower crystallinity and melting point as well as greater flexibility, which broadens its industrial applicability [4,5]. In order to confer active properties to PHAs, several substances can be incorporated into the biopolymers such as essential oils (EOs) and inorganic or metal nanoparticles (MNPs) [6,7].EOs are the product of the secondary metabolism of plants, separated from the aqueous phase, which is formed by various volatile components such as terpenes, alcohols, acids, esters, epoxies, aldehydes, ketones, amines, and sulphides, among others [8]. This wide range of compounds are responsible for the strong biological activity and also the antioxidant, antimicrobial, antifungal, and antiviral properties of plants [9]. In addition, EOs are biologically safe and have a low risk of causing resistance in pathogens [10]. In addition, they are classified as Generally Recognized as Safe (GRAS) by the U.S. Food and Drug Administration (FDA) [11]. Among them, oregano essential oil (OEO) is one of the most important and it is widely used in the pharmaceutical, food, and cosmetics industries [12]. It comes from the genus Origanum that belongs to the Lamiaceae family [13], which is constituted by more than 38 monoterpenoids [14]. Their main active compounds are carvacrol, thymol, p-cymene, and γ-terpinene, which are responsible for its high antimicrobial and antioxidant activities [15,16]. These active compounds have been particularly related to the inhibition of G− bacteria such as Escherichia coli (E. coli), Pseudomonas aeruginosa (P. aeruginosa), and Salmonella typhimurium (S. typhimurium) and G+ bacteria including Staphylococcus aureus (S. aureus), Listeria mo...

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“…We have also studied the various factors influencing both chitosan membrane characteristics and extent of immobilization. A versatile chitosan/ZnO composite membranes was also successfully prepared by our group [28] using these macroporous chitosan membranes and nano ZnO obtained from tea extract by green synthesis method. This chitosan/ZnO composite membrane was also tested for its antimicrobial activities and indeed the chitosasn/ZnO composited showed enhanced antimicrobial activities when compared with chtiosan alone.…”

Section: Citationmentioning

confidence: 99%

A Short Review on Chitosan Membrane for Biomolecules Immobilization

JF¹

2015

J Mol Genet Med

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Chitosan is an important natural polymer that occurs in the world. Chitosan is soluble in acidic aqueous media and it can be obtained in various forms. It is widely used for many applications. Hence, we briefly describe the role of chitosan in membrane form, an important area of research in which a variety of synthetic methods has been proposed and their significance is explained. Thus, this review emphasizes the papers on the high value-added applications of these chitosan membranes in diverse fields such as medicine, biological, cosmetics and nanotechnology.

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A versatile chitosan/ZnO nanocomposite with enhanced antimicrobial properties

Cited by 108 publications

References 41 publications

Antifungal activity of ZnO thin films prepared by glancing angle deposition

Antifungal activity of ZnO thin films prepared by glancing angle deposition

Electrospun Active Biopapers of Food Waste Derived Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) with Short-Term and Long-Term Antimicrobial Performance

A Short Review on Chitosan Membrane for Biomolecules Immobilization

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