A vertebral extra dural chordoma at C5, possibly deriving from a clival chordoma

Góes, Roberto Wagner Lopes; Overbeeke, J.J. van

doi:10.4103/2152-7806.157948

Cited by 3 publications

(4 citation statements)

References 16 publications

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“…Finally, there were 38 studies included in this review, with a total of 40 included cases. 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 Study dates ranged from 1949–2022, with 10 studies being published prior to the 21st century. There were 9, 15, and 4 studies that were published between 2000–2009, 2010–2019, and 2020 onwards, respectively.…”

Section: Resultsmentioning

confidence: 99%

“…Two titles were found to be journal supplements and were excluded. Finally, there were 38 studies included in this review, with a total of 40 included cases 11–49 . Study dates ranged from 1949–2022, with 10 studies being published prior to the 21st century.…”

Section: Resultsmentioning

confidence: 99%

“… APPENDIX S2 Included cases with quality appraisal 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 …”

Section: Supporting Informationunclassified

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Metastatic skull base chordoma: A systematic review

Young

Nielsen

Bulosan

et al. 2022

Laryngoscope Investig Oto

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Objective/Hypothesis To investigate the clinical features, management strategies and outcomes for patients with metastatic primary skull base chordomas. Study Design Systematic review. Methods A systematic search through Pubmed/Medline, Web of Science, and EBSCOhost (CINAHL) was conducted without restriction on dates. After study screening and full‐text assessment, two authors independently extracted all data using a pre‐established abstraction form. Results Forty cases were included from 38 studies. The average age (standard deviation [SD]) of the sample at presentation was 28.5 (23.3) and was equally distributed across genders. The average time (SD) between initial diagnosis to local recurrence was 40.1 (60.3) months. The average time (SD) from primary tumor detection to the diagnosis of metastatic disease was 55.2 (49.0) months. The most common subsite for metastatic spread were the lungs (32.5%). Of the 33 patients with data on outcomes, 48.5% were found to have expired by the time of publication. The median overall survival was estimated to be 84 months (95% confidence interval [CI] 62.3–105.7). Conclusions The most common subsites for metastatic spread of skull base chordoma were the lungs and bone. Overall survival for patients in the current cohort was a median of 84 months, with no significant differences noted when stratifying by the extent of surgery or the site of metastases. Level of Evidence 3a

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Metastatic skull base chordoma: A systematic review

Young

Nielsen

Bulosan

et al. 2022

Laryngoscope Investig Oto

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“…Various chordoma treatment regimens and approaches have been attempted, including complete surgical resection, combined radiation, surgical excision, and radiotherapy. However, complete resection and determining widely negative surgical margins can often be challenging, given the proximity of the tumor to critical neurovascular structures, its slow growth patterns, the tendency to recur, and its resistance to traditional chemo- and radiotherapeutic modalities [ 34 , 35 ]. As such, to attain as radical a resection as possible while avoiding tumor spillage, the capsule should be left intact [ 36 ].…”

Section: Discussionmentioning

confidence: 99%

Cervical Paraspinal Chordoma: A Literature Review with a Novel Case Report

Jabbar

Jankowski

Pawełczyk

et al. 2022

JCM

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Chordomas are rare malignant neoplasms, accounting for 1–4% of all primary bone tumors. Most spinal chordomas occur in the sacrococcygeal region and the base of the skull; however, 6% of chordomas are observed in the cervical spine. In these cases, the lesion is mainly located in the midline. These tumors slowly grow before becoming symptomatic and encase the surrounding vascular and nerve structures. Patients with advanced chordoma have a poor prognosis due to local recurrence with infiltration and destruction of adjacent bone and tissues. Systemic chemotherapy options have not been fully effective in these tumors, especially for recurrent chordomas. Thus, new combinations of currently available targeted molecular and biological therapies with radiotherapy have been proposed as potential treatment modalities. Here, the present paper describes the case of a 41-year-old male with a C2–C4 chordoma located paravertebrally, who underwent surgical resection with a debulking procedure for a cervical chordoma. Computed tomography angiography revealed a paraspinal mass with bone remodeling and the MRI showed a paravertebral mass penetrating to the spinal canal with a widening of the intervertebral C2–C3 foramen. Initially, the tumor was diagnosed as schwannoma based on its localization and imaging features; however, the histopathology specimen confirmed the diagnosis of chordoma. This case study highlights the effectivity of radical surgical resection as a mainstay treatment for chordomas, discusses neuroimaging, diagnosis, and the use of currently available targeted therapies and forthcoming treatment strategies, as alternative treatment options for chordoma.

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Clival chordoma with drop metastases

2018

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Chordoma is a rare midline malignant tumor arising from embryonic remnants of the primitive notochord. The base of the skull is the second most common site of disease after the sacrococcygeal region. Intracranial chordoma constitutes about 30-35% of chordoma cases. Metastasis from chordoma is uncommon but if occurs, it tends to spread to the lungs. Cerebrospinal fluid seeding or drop metastasis is very rare. Here we describe a case of a clival chordoma with drop metastases.

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A vertebral extra dural chordoma at C5, possibly deriving from a clival chordoma

Cited by 3 publications

References 16 publications

Metastatic skull base chordoma: A systematic review

Metastatic skull base chordoma: A systematic review

Cervical Paraspinal Chordoma: A Literature Review with a Novel Case Report

Clival chordoma with drop metastases

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