A Very Simple and Sensitive Spectrofluorimetric Method Based on the Oxidation with Cerium (IV) for the Determination of Four Different Drugs in Their Pharmaceutical Formulations

Bavili-Tabrizi, Ahad; Bahrami, Farshad; Badrouj, Hossein

doi:10.15171/ps.2017.08

Cited by 8 publications

(5 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Chromatographic [5][6][7][8], electrophoretic [9-11], polarographic [12,13], fluorometric [14][15][16][17], and spectrophotometric [18][19][20][21] methods are all viable options for evaluating dopamine hydrochloride and methyldopa.…”

Section: Fig 2 Chemical Formula Of Methyldopamentioning

confidence: 99%

Coomassie Brilliant Blue Staining Used in Spectrophotometric Assay for Dopamine Hydrochloride and Methyldopa Determination

Ahmad,

Dhamra

2024

Chemical Problems

View full text Add to dashboard Cite

The catalytic oxidation reaction between Coomassie Brilliant Blue and N-bromosuccinimide was used in an acidic medium to develop a spectrophotometric method for the estimation of dopamine and methyldopa in their pure forms and in pharmaceutical preparations. The developed method exhibited high sensitivity, with molar absorptivity values of 1.77 × 104 and 2.97 × 104 L mol-1 cm -1 , and Sandell's sensitivity values of 0.0080 and 0.0107 mg cm-2 , respectively. The estimated quantities of dopamine hydrochloride and methyldopa were within the range of 0.5-18 μg/mL and 0.5-13 μg/mL, respectively. The developed method was successfully applied to tablet and injection formulations, and the results were in accord with the original drug content. The developed method was compared with standard addition and standard method in the British Pharmacopoeia, and no significant differences were revealed thus confirming the success of the developed method in the estimation of the studied drugs. Other statistical values were also studied .

show abstract

Section: Fig 2 Chemical Formula Of Methyldopamentioning

confidence: 99%

Coomassie Brilliant Blue Staining Used in Spectrophotometric Assay for Dopamine Hydrochloride and Methyldopa Determination

Ahmad,

Dhamra

2024

Chemical Problems

View full text Add to dashboard Cite

show abstract

“…Effect of pH. -The absorbance and photoluminescence of colloidal AuNP dispersions was measured at different pH values (4)(5)(6)(7)(8)(9)(10). At pH ≤ 4, the negative charge of citrate anions surrounding the gold nanoparticles became fully protonated and the Au nanoparticles were aggregated; hence the stability of the suspension form decreased.…”

Section: Diameter Of Aunpsmentioning

confidence: 99%

Spectrofluorimetric method for atenolol determination based on gold nanoparticles

et al. 2018

View full text Add to dashboard Cite

A simple and sensitive spectrofluorimetric method for determination of atenolol (ATE) using gold nanoparticles (AuNPs) was developed. The method is based on the quenching effect of atenolol on photoluminescence of AuNPs at λem = 705 nm. Variables affecting luminescence of gold nanoparticles such as the solvent, pH value and surfactant were studied and optimized. The method was preliminarily validated according to ICH guidelines. A linear correlation was recorded within the range of 1.0-10 mg mL-1 ATE with the coefficient of determination R2 of 0.999. The limit of detection and limit of quantitation for atenolol were found to be 0.87 and 2.64 mg mL-1, resp. Good recoveries in the range of 98.7-100.0 % were obtained for spiked samples. The proposed method was applied successfully to assaying atenolol in pharmaceuticals formulations.

show abstract

“…Previous studies applied spectrofluorometry to estimation of atenolol in aqueous solution and samples human urine because of its sensitivity, selectivity and low cost instrumentation [8]. Photoluminescence of metal nanoparticles that offer emission of light without requiring conjugation with luminous dyes is the basis for the new method [9]. Determination of atenolol by using high performance liquid chromatographic (HPLC) [10][11][12][13][14], Uv-vis spectrophotometry [3,[15][16][17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Assessment of Long Distance Chasing Photometer (NAG-ADF-300-2) by Estimating the Drug Atenolol with Povidone Iodine Via CFIA

Mezaal¹

2020

IHJPAS

View full text Add to dashboard Cite

Atenolol was used with povidone iodine to prove the efficiency, reliability and repeatability of the long distance chasing photometer (NAG-ADF-300-2) using continuous flow injection analysis. The method is based on reaction between atenolol and povidone iodine in an aqueous medium. Optimum parameters was studied to increase the sensitivity development of method. Calibration graph was linear in the range of 2-19 mmol/L for cell A and 5-19 mmol/L for cell B. Limit of detection 146.4848 ng/55 µL and 2.6600 µg/200 µL respectively to cell A and cell B. Correlation coefficient (r) 0.9957 for cell A and 0.9974 for cell. Relative standard deviation (RSD %) was lower than 1%, (n=8) for the determination of atenolol at concentration (5, 9 and 17) mmol/L for cell A and (5, 13 and 17) mmol/L for cell B respectively. The results were compared with classical method UV-spectrophotometric at λ max=270 nm by using method standard addition via t-test, at 95% confidence level. The comparison of data explain that long distance chasing photometer (NAG-ADF-300-2) is the choice with excellent extended detection and wide application.

show abstract

A Very Simple and Sensitive Spectrofluorimetric Method Based on the Oxidation with Cerium (IV) for the Determination of Four Different Drugs in Their Pharmaceutical Formulations

Cited by 8 publications

References 31 publications

Coomassie Brilliant Blue Staining Used in Spectrophotometric Assay for Dopamine Hydrochloride and Methyldopa Determination

Coomassie Brilliant Blue Staining Used in Spectrophotometric Assay for Dopamine Hydrochloride and Methyldopa Determination

Spectrofluorimetric method for atenolol determination based on gold nanoparticles

Assessment of Long Distance Chasing Photometer (NAG-ADF-300-2) by Estimating the Drug Atenolol with Povidone Iodine Via CFIA

Contact Info

Product

Resources

About