2023
DOI: 10.1101/2023.08.28.555129
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A viral vector model for circuit-specific synucleinopathy

Alexia Lantheaume,
Nina Schöneberg,
Silvia Rodriguez-Rozada
et al.

Abstract: In Parkinson’s disease (PD), pathomechanisms such as aberrant network dysfunctions can be elucidated by conducting multiscale explorations in animal models. However, the lack of specificity in the existing models limits a restricted targeting of individual network elements and characterization of PD as a “circuitopathy”. We therefore developed a cell-type specific viral vector (AAV2/9-CreON-A53T-αSyn) mouse model that allows to induce synucleinopathy within individual circuit elementsin vivo. When specifically… Show more

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