A viscoelastic analysis of the P56 mouse brain under large-deformation dynamic indentation

MacManus, David B.; Pierrat, Baptiste; Murphy, Jeremiah G.; Gilchrist, Michael D.

doi:10.1016/j.actbio.2016.10.029

Cited by 40 publications

(39 citation statements)

References 40 publications

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“…Finite element (FE) models of brain provide a non-invasive way to analyse the brain response to head impacts [59]. The viscoelastic parameters as material constants in simulations were mostly taken from indentation [2], stress-strain and stress relaxation tests [11,60] where an N-term Prony series were used to fit the experimental data. The frequency-dependent properties of brain tissue are also important in FE simulations to analyse the mechanical response under dynamic loading.…”

Section: Discussionmentioning

confidence: 99%

“…The storage ( ′ ) and loss stiffness ( ′′ ) were calculated using Eqs. (1) and (2). Further details on the characterisation are provided elsewhere [31,33,36].…”

Section: Methodsmentioning

confidence: 99%

“…Although the brain is well protected by the skull, traumatic brain injury (TBI) is still a major cause of death and disability induced by external forces [1]. Primary brain damage is caused by direct impact of a penetrating object at a rapid speed or under blast loading conditions [2]. Low-acceleration oscillations of the head can also induce mild brain trauma [3].…”

Section: Introductionmentioning

confidence: 99%

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Frequency dependent viscoelastic properties of porcine brain tissue

Shepherd

Espino

2020

Journal of the Mechanical Behavior of Biomedical Materials

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Where a licence is displayed above, please note the terms and conditions of the licence govern your use of this document. When citing, please reference the published version. Take down policy While the University of Birmingham exercises care and attention in making items available there are rare occasions when an item has been uploaded in error or has been deemed to be commercially or otherwise sensitive.

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Section: Discussionmentioning

confidence: 99%

“…The storage ( ′ ) and loss stiffness ( ′′ ) were calculated using Eqs. (1) and (2). Further details on the characterisation are provided elsewhere [31,33,36].…”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Frequency dependent viscoelastic properties of porcine brain tissue

Shepherd

Espino

2020

Journal of the Mechanical Behavior of Biomedical Materials

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“…The viscoelastic nature of the brain contributes to its unique mechanical properties, and different ECM compartments of the brain (Cowman et al, 2015), neuronal cell types and even intercellular compartments could vary greatly in viscoelastic parameters (Lu et al, 2006). Because these differences are just beginning to be understood, and often in the context of repair after traumatic injury (MacManus et al, 2016;Li et al, 2016;Johnson et al, 2016), we do not address viscoelastic properties in great detail in this review.…”

Section: Mechanotransductionmentioning

confidence: 99%

Tissue mechanics regulate brain development, homeostasis and disease

Barnes

Przybyla

Weaver

2017

Journal of Cell Science

271

245

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All cells sense and integrate mechanical and biochemical cues from their environment to orchestrate organismal development and maintain tissue homeostasis. Mechanotransduction is the evolutionarily conserved process whereby mechanical force is translated into biochemical signals that can influence cell differentiation, survival, proliferation and migration to change tissue behavior. Not surprisingly, disease develops if these mechanical cues are abnormal or are misinterpreted by the cells – for example, when interstitial pressure or compression force aberrantly increases, or the extracellular matrix (ECM) abnormally stiffens. Disease might also develop if the ability of cells to regulate their contractility becomes corrupted. Consistently, disease states, such as cardiovascular disease, fibrosis and cancer, are characterized by dramatic changes in cell and tissue mechanics, and dysregulation of forces at the cell and tissue level can activate mechanosignaling to compromise tissue integrity and function, and promote disease progression. In this Commentary, we discuss the impact of cell and tissue mechanics on tissue homeostasis and disease, focusing on their role in brain development, homeostasis and neural degeneration, as well as in brain cancer.

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“…The Hertz contact theory relates load to stiffness during indentation. The associated assumptions can be difficult to satisfy experimentally, although finite element modeling can address this (Finan et al, 2014;Pierrat et al, 2017). Indentation has been used to measure human brain stiffness in small tissue specimens resected during surgery (Finan et al, 2017).…”

Section: Brain Stiffness Measurement In Humans and Large Animalsmentioning

confidence: 99%

Biomechanical simulation of traumatic brain injury in the rat

Finan

2019

Clinical Biomechanics

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Important progress in mathematical modeling and measurement of biomechanical properties has led to credible, predictive simulations of traditional, experimental models of traumatic brain injury in the rat, such as controlled cortical impact. However, recent trends such as the increasing popularity of closed head models and blast models create new biomechanical challenges. Investigators studying rat brain biomechanics must continue to innovate to keep pace with these developments.

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A viscoelastic analysis of the P56 mouse brain under large-deformation dynamic indentation

Cited by 40 publications

References 40 publications

Frequency dependent viscoelastic properties of porcine brain tissue

Frequency dependent viscoelastic properties of porcine brain tissue

Tissue mechanics regulate brain development, homeostasis and disease

Biomechanical simulation of traumatic brain injury in the rat

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