A volatile from the skin microbiota of flavivirus-infected hosts promotes mosquito attractiveness

Zhang, Hong; Zhu, Yibin; Liu, Ziwen; Peng, Yongmei; Peng, Wenyu; Tong, Liangqin; Wang, Jinglin; Liu, Qiyong; Wang, Penghua; Cheng, Gong

doi:10.1016/j.cell.2022.05.016

Cited by 58 publications

(53 citation statements)

References 45 publications

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“…To address the role of these mutations in DENV pathogenicity in mammalian hosts, we infected the type I and II interferon receptors double‐deficient ( ifnar −/− + ifngr −/− ) C57BL/6 mouse (AG6 mouse) with either DENV mutants or their parental viruses (Fig 2E–H). The AG6 mouse is an animal model that is commonly used to study DENV infections (Orozco et al , 2012; Zhu et al , 2021; Zhang et al , 2022b). Intriguingly, 16681‐T226K presented slightly lower viremia than the 16681 strain; nonetheless, a glycine (G) to glutamic acid (E) mutation at the 228 th residue (16681‐G228E), which is a neighboring substitution of the 226 th site, resulted in significantly higher viremia (Fig 2E).…”

Section: Resultsmentioning

confidence: 99%

Neighboring mutation‐mediated enhancement of dengue virus infectivity and spread

et al. 2022

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Frequent turnover of dengue virus (DENV) clades is one of the major forces driving DENV persistence and prevalence. In this study, we assess the fitness advantage of nine stable substitutions within the envelope (E) protein of DENV serotypes. Two tandem neighboring substitutions, threonine to lysine at the 226th (T226K) and glycine to glutamic acid at the 228th (G228E) residues in the DENV2 Asian I genotype, enhance virus infectivity in either mosquitoes or mammalian hosts, thereby promoting clades turnover and dengue epidemics. Mechanistic studies indicate that the substitution‐mediated polarity changes in these two residues increase the binding affinity of E for host C‐type lectins. Accordingly, we predict that a G228E substitution could potentially result in a forthcoming epidemic of the DENV2 Cosmopolitan genotype. Investigations into the substitutions associated with DENV fitness in hosts may offer mechanistic insights into dengue prevalence, thus providing a warning of potential epidemics in the future.

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Section: Resultsmentioning

confidence: 99%

Neighboring mutation‐mediated enhancement of dengue virus infectivity and spread

et al. 2022

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“…Mice and humans infected by flaviviruses present higher attraction to A. aegypti , as described in our previous study. 1 More mosquitoes entered the chamber of ZIKV/DENV2-infected mice at 4 and 6 days postinfection than those flowing into the chamber of healthy mice. The palms with n -hexane extracts from dengue patients presented higher attraction to mosquitoes than those with n -hexane extracts from healthy donors.…”

Section: Expected Outcomesmentioning

confidence: 97%

Protocol for host volatile collection and mosquito behavior assays

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Zhu

et al. 2023

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“…Skin microbes metabolize host sweat and produce volatile metabolites, enhancing the attractiveness of human sweat for the malaria mosquito (Brouwer 1960 ; Takken and Kline 1989 ). A recent study specified acetophenone, a volatile from the skin microbiota, promoted mosquito attractiveness in flavivirus-infected hosts (Zhang et al 2022 ).…”

Section: From Microbes To Host Skin: How Microbes Reshape the Skin Ph...mentioning

confidence: 99%

Skin Microbiome, Metabolome and Skin Phenome, from the Perspectives of Skin as an Ecosystem

et al. 2022

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Skin is a complex ecosystem colonized by millions of microorganisms, including bacteria, fungi, and viruses. Skin microbiota is believed to exert critical functions in maintaining host skin health. Profiling the structure of skin microbial community is the first step to overview the ecosystem. However, the community composition is highly individualized and extremely complex. To explore the fundamental factors driving the complexity of the ecosystem, namely the selection pressures, we review the present studies on skin microbiome from the perspectives of ecology. This review summarizes the following: (1) the composition of substances/nutrients in the cutaneous ecological environment that are derived from the host and the environment, highlighting their proposed function on skin microbiota; (2) the features of dominant skin commensals to occupy ecological niches, through self-adaptation and microbe–microbe interactions; (3) how skin microbes, by their structures or bioactive molecules, reshape host skin phenotypes, including skin immunity, maintenance of skin physiology such as pH and hydration, ultraviolet (UV) protection, odor production, and wound healing. This review aims to re-examine the host–microbe interactions from the ecological perspectives and hopefully to give new inspiration to this field.

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A volatile from the skin microbiota of flavivirus-infected hosts promotes mosquito attractiveness

Cited by 58 publications

References 45 publications

Neighboring mutation‐mediated enhancement of dengue virus infectivity and spread

Neighboring mutation‐mediated enhancement of dengue virus infectivity and spread

Protocol for host volatile collection and mosquito behavior assays

Skin Microbiome, Metabolome and Skin Phenome, from the Perspectives of Skin as an Ecosystem

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