A volatile microemulsion method of preparing water-soluble photo-absorbers for 3D printing of high-resolution, high-water-content hydrogel structures

He, Xiangnan; Cheng, Jianxiang; Sun, Zechu; Ye, Haitao; Liu, Qingjiang; Zhang, Biao; Ge, Qi

doi:10.1039/d2sm01709a

Cited by 9 publications

(5 citation statements)

References 55 publications

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“…However, limitations exist in the printing resolution and rat models. The potential approaches that may improve the printing resolution include the increase in light source resolution or the addition of specific biomacromolecules to inhibit free radical polymerization at unexposed areas during photoinitiation 76 , 77 . Moreover, diabetic wound models of rats created by injection of STZ only represent part of complex diabetic wound pathophysiology in human bodies; therefore, additional trials on large mammals or patients are needed to perform to validate the treatment and determine a specific usage.…”

Section: Discussionmentioning

confidence: 99%

A click chemistry-mediated all-peptide cell printing hydrogel platform for diabetic wound healing

Huang,

Yang,

Jiao

et al. 2023

Nat Commun

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High glucose-induced vascular endothelial injury is a major pathological factor involved in non-healing diabetic wounds. To interrupt this pathological process, we design an all-peptide printable hydrogel platform based on highly efficient and precise one-step click chemistry of thiolated γ-polyglutamic acid, glycidyl methacrylate-conjugated γ-polyglutamic acid, and thiolated arginine-glycine-aspartate sequences. Vascular endothelial growth factor 165-overexpressed human umbilical vein endothelial cells are printed using this platform, hence fabricating a living material with high cell viability and precise cell spatial distribution control. This cell-laden hydrogel platform accelerates the diabetic wound healing of rats based on the unabated vascular endothelial growth factor 165 release, which promotes angiogenesis and alleviates damages on vascular endothelial mitochondria, thereby reducing tissue hypoxia, downregulating inflammation, and facilitating extracellular matrix remodeling. Together, this study offers a promising strategy for fabricating tissue-friendly, high-efficient, and accurate 3D printed all-peptide hydrogel platform for cell delivery and self-renewable growth factor therapy.

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Section: Discussionmentioning

confidence: 99%

A click chemistry-mediated all-peptide cell printing hydrogel platform for diabetic wound healing

Huang,

Yang,

Jiao

et al. 2023

Nat Commun

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“…This innovation enables the creation of diverse 3D structures that maintain integrity without deformation, enhancing the potential for practical applications [20]. Furthermore, improvements in the 3D printing resolution of Digital Light Processing (DLP) for high-water-content hydrogels have been achieved through the use of water-soluble photo-absorbers, which serve to enhance both mechanical properties and biocompatibility [101]. Figure 5 below shows a picture of an extrusion-based 3D printer and different views of 3D-printed structures.…”

Section: Self-healing and Responsive Hydrogelsmentioning

confidence: 99%

“…For self-healing and responsive hydrogels, ensuring long-term durability under repetitive stress conditions is a challenge [20,102,103]. Developing hydrogels that respond rapidly to stimuli requires further optimization [101,104,111]. Scalability and the simplification of manufacturing processes, without compromising functionality, are essential for sustainable development, alongside integration with electronic and biomedical systems and addressing environmental stability and degradability [105][106][107]110,112,113,115,117,118].…”

Section: Limitations Of Using 3d Printed Hydrogelsmentioning

confidence: 99%

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Three-Dimensional Printing Strategies for Enhanced Hydrogel Applications

Omidian,

Mfoafo

2024

Gels

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This study explores the dynamic field of 3D-printed hydrogels, emphasizing advancements and challenges in customization, fabrication, and functionalization for applications in biomedical engineering, soft robotics, and tissue engineering. It delves into the significance of tailored biomedical scaffolds for tissue regeneration, the enhancement in bioinks for realistic tissue replication, and the development of bioinspired actuators. Additionally, this paper addresses fabrication issues in soft robotics, aiming to mimic biological structures through high-resolution, multimaterial printing. In tissue engineering, it highlights efforts to create environments conducive to cell migration and functional tissue development. This research also extends to drug delivery systems, focusing on controlled release and biocompatibility, and examines the integration of hydrogels with electronic components for bioelectronic applications. The interdisciplinary nature of these efforts highlights a commitment to overcoming material limitations and optimizing fabrication techniques to realize the full potential of 3D-printed hydrogels in improving health and well-being.

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“…published a volatile microemulsion method for converting non‐water soluble photoabsorbers into water‐soluble nanoparticles, which were shown to be effective in multimaterial hydrogel 4D printing of NIPAm and acrylamide bilayers. [ 122 ]…”

Section: Vat‐switching During Multimaterials Hydrogel 3d Printingmentioning

confidence: 99%

Multimaterial Hydrogel 3D Printing

Imrie,

Jin

2023

Macro Materials & Eng

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In recent years, hydrogels have emerged as quintessential 3D printing materials. Coupled with their inherent printability, the unique mechanical properties, network structure, and biocompatibility of hydrogels make them ideal for a wide range of 3D printing applications. Also in recent years, the rise of multimaterial 3D printing, an additive manufacturing technology which involves at least two different materials in the fabrication process, has been witnessed. Advanced multimaterial 3D printing protocols have brought the field closer than ever before to a new industrial revolution. In this review, the use of hydrogels in multimaterial 3D printing is investigated. The review is sectioned by discussing three major multimaterial 3D printing methods: direct‐ink‐writing, vat‐switching, and coaxial extrusion. Subsections detail three common domains of multimaterial hydrogel 3D printing: bioprinting, 4D printing, and particle‐polymer composite printing. In the second part of the review, recent advancements in both multimaterial 3D printing hardware and hydrogel inks which are expected to steer the field in exciting new directions are explored. Finally, a case is made for coaxial extrusion and light‐responsive printers being the best choice for multimaterial hydrogel 3D printing in the long run, due to their gradient and greyscale printing capabilities.

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A volatile microemulsion method of preparing water-soluble photo-absorbers for 3D printing of high-resolution, high-water-content hydrogel structures

Abstract: Digital Light Processing (DLP)-based three-dimensional (3D) printing is an ideal tool to manufacture hydrogel structures in complex 3D forms. Using DLP to print hydrogel structures with high resolution requires addition...

Cited by 9 publications

References 55 publications

A click chemistry-mediated all-peptide cell printing hydrogel platform for diabetic wound healing

A click chemistry-mediated all-peptide cell printing hydrogel platform for diabetic wound healing

Three-Dimensional Printing Strategies for Enhanced Hydrogel Applications

Multimaterial Hydrogel 3D Printing

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