A voluntary registry for peanut and tree nut allergy: Characteristics of the first 5149 registrants☆

Sicherer, Scott H.; Furlong, T.J.; Muñoz-Furlong, Anne; Burks, A. Wesley; Sampson, Hugh A.

doi:10.1067/mai.2001.115755

Cited by 326 publications

(296 citation statements)

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“…Several studies reported the co-occurrence of other allergic conditions in adult patients with food allergy, such as: asthma (34 -49 % ), allergic rhinitis (33 -40 % ), and atopic dermatitis (35 -71 % ) ( 42,43 ). However, it must be said that the above studies ( 41 -43 ) referred to patients with IgE-mediated food allergy, a condition that -by defi nition -excludes NCWS.…”

Section: The Association Between Ncws and Atopic Diseasesmentioning

confidence: 92%

Non-Celiac Wheat Sensitivity as an Allergic Condition: Personal Experience and Narrative Review

Carroccio

Mansueto

D’Alcamo

et al. 2013

American Journal of Gastroenterology

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OBJECTIVES:Non-celiac wheat sensitivity (NCWS) is a newly described clinical entity characterized by symptoms, which can involve the gastrointestinal tract, the nervous system, the skin, and other organs. There is little data on the pathogenesis of NCWS and it is probable that different pathogenic mechanisms are involved in the different clinical manifestations of the disease. The only common denominator of NCWS " syndrome " is wheat consumption: the symptoms disappear on exclusion of wheat from the diet, and reappear on wheat consumption. The objective of this study was to review our prior data regarding NCWS and to review relevant medical literature regarding NCWS, with particular attention to the hypothesis that NCWS patients could suffer from non-immunoglobulin E (IgE)-mediated wheat allergy. METHODS:We reviewed our data on 276 patients diagnosed with NCWS by means of double-blind placebocontrolled (DBPC) wheat challenge. The data indicating a possible wheat allergy diagnosis were examined and other data in the literature were reviewed; we review the role of serum immunoglobulin G antibodies and the basophil activation assay in food allergy, and the histology fi ndings in the food allergy diagnosis. RESULTS:The comparison between patients suffering from NCWS and presenting with irritable bowel syndrome (IBS) and controls with IBS not due to NCWS showed that NCWS was characterized by: a personal history of food allergy in the pediatric age (0.01), coexistent atopic diseases (0.0001), positive serum anti-gliadin (0.0001) and anti-betalactoglobulin (0.001) antibodies, positive cytofl uorimetric assay revealing in vitro basophil activation by food antigens (0.0001), and a presence of eosinophils in the intestinal mucosa biopsies (0.0001).CONCLUSIONS: Patients with NCWS and multiple food sensitivity show several clinical, laboratory, and histological characteristics that suggest they might be suffering from non-IgE-mediated food allergy. However, other pathogenic mechanisms need to be considered.

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Section: The Association Between Ncws and Atopic Diseasesmentioning

confidence: 92%

Non-Celiac Wheat Sensitivity as an Allergic Condition: Personal Experience and Narrative Review

Carroccio

Mansueto

D’Alcamo

et al. 2013

American Journal of Gastroenterology

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“…Although cashew nut allergy is reported as a common tree nut allergy, we found only a few studies on the prevalence of cashew nut allergy (10). The search yielded studies suggesting an increase in cashew nut allergy in children and an increased recognition of cashew nut allergy in clinical practice (2,3,5).…”

Section: Epidemiologymentioning

confidence: 93%

Systematic review on cashew nut allergy

Valk

Dubois

Wijk

et al. 2014

Allergy

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Recent studies on cashew nut allergy suggest that the prevalence of cashew nut allergy is increasing. Cashew nut consumption by allergic patients can cause severe reactions, including anaphylaxis. This review summarizes current knowledge on cashew nut allergy to facilitate timely clinical recognition and to promote awareness of this emerging food allergy amongst clinicians. The goal of this study is to present a systematic review focused on the clinical aspects of allergy to cashew nut including the characteristics of cashew nut, the prevalence, allergenic components, cross-reactivity, diagnosis and management of cashew nut allergy. The literature search yielded 255 articles of which 40 met our selection criteria and were considered to be relevant for this review. The 40 articles included one prospective study, six retrospective studies and seven case reports. The remaining 26 papers were not directly related to cashew nut allergy. The literature suggests that the prevalence of cashew nut allergy is increasing, although the level of evidence for this is low. A minimal amount of cashew nut allergen may cause a severe allergic reaction, suggesting high potency comparable with other tree nuts and peanuts. Cashew allergy is clearly an underestimated important healthcare problem, especially in children.Although peanut allergy has been on the increase for two decades or more, studies indicate that cashew nut is also becoming an important food allergen (1, 2). The rapid increase in consumption of cashew nuts and the change in eating and cooking habits may be responsible for the increasing significance of cashew nut allergy (2).In this paper, we summarize the relevant information available on epidemiology, allergen components, clinical features, diagnosis, clinical and in vitro cross-sensitization and management of cashew nut allergy. Data sources and literature searchIn our search, we adhered to the methods and procedures of the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines for reporting this systematic review, excluding irrelevant items. Registration number in PROSPERO is CRD42013004047.We used Ovid MEDLINE and EMBASE databases to identify relevant articles using the string: (Anacardi* sensitiv*) OR allerg*): de, ab, ti for EMBASE. We also checked references to relevant articles ('snowballing').We aimed to include studies focused on the clinical aspects of cashew nut allergy. We considered only studies in English. There was no restriction on publication date. Mouse model studies were excluded. Initially, all articles on cashew nut allergy or on cashew nuts were included. Thereafter articles on contact dermatitis, genetics, product labelling, poisoning, detection methods and possible medicinal effects of cashew plants were excluded. Forty of 255 articles found with the literature search (244 articles) and by 'snowballing (11 articles) were considered relevant for the review. Of these 40 articles, one article was a prospective study and six articles were retrospective stu...

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“…Peanut allergy is one of the most common and serious types of IgE-mediated food allergies in terms of persistency and severity 16,17 and seems to be an increasing problem in the western world. 18,19 The peanut protein Ara h 1, which is a major allergen, 20,21 is a 7S globulin protein belonging to the cupin superfamily of allergens.…”

Section: ■ Introductionmentioning

confidence: 99%

Digested Ara h 1 Loses Sensitizing Capacity When Separated into Fractions

Bøgh

Barkholt²,

Rigby

et al. 2012

J. Agric. Food Chem.

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The major peanut allergen Ara h 1 is an easily digestible protein under physiological conditions. The present study revealed that pepsin digestion products of Ara h 1 retained the sensitizing potential in a Brown Norway rat model, while this sensitizing capacity was lost by separating the digest into fractions by gel permeation chromatography. Protein chemical analysis showed that the peptide composition as well as the aggregation profiles of the fractions of Ara h 1 digest differed from that of the whole pool. These results indicate that the sensitizing capacity of digested Ara h 1 is a consequence of the peptides being in an aggregated state resembling the intact molecule or that most peptides of the digests need to be present in the same solution, having a synergistic or adjuvant effect and thereby augmenting the immune response against other peptides.

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A voluntary registry for peanut and tree nut allergy: Characteristics of the first 5149 registrants☆

Cited by 326 publications

References 0 publications

Non-Celiac Wheat Sensitivity as an Allergic Condition: Personal Experience and Narrative Review

Non-Celiac Wheat Sensitivity as an Allergic Condition: Personal Experience and Narrative Review

Systematic review on cashew nut allergy

Digested Ara h 1 Loses Sensitizing Capacity When Separated into Fractions

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