A water-soluble fluorescent probe for monitoring mitochondrial GSH fluctuations during oxidative stress

Wang, Huayu; Zhang, Luan; Jin, Xin; Tian, Peijiao; Ding, Xiaoqing; Chang, Jing

doi:10.1039/d2ra04732b

“…Developing novel optical and biological-responsive tools meets the expectations of technological and scienti c demands. Biologically performant macro or nano-sized AIE polymers [10,[54][55][56][57] play a key role among the modern monitorable theranostic tools [58,59]. Hybrid polymers obtained by grafting metalloorganic fragments on preformed chelating polymers combine the easy and tuneable synthesis with the speci c features brought by the coordination fraction.…”

Section: Chemistry Of the Grafted Polymersmentioning

confidence: 99%

AIEgen orthopalladated hybrid polymers for efficient inactivation of the total coliforms in urban wastewater

Sessa

¹

,

Diana

²

,

Gentile

³

et al. 2023

Preprint

0

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Monitorable AIE polymers with a bioactive pattern are employed in advanced biomedical applications such as functional coatings, theranostic probes, and implants. After the global COVID-19 pandemic, interest in developing surfaces with superior antimicrobial, antiproliferative, and antiviral activities dramatically increased. Many formulations for biocide surfaces are based on hybrid organic/inorganic materials. Palladium (II) complexes display relevant activity against common bacteria, even higher when compared to their uncoordinated ligands. This article reports the design and synthesis of two series of orthopalladated polymers obtained by grafting a cyclopalladated fragment on two different O, N chelating Schiff base polymers. Different grafting percentages were examined and compared for each organic polymer. The fluorescence emission in the solid state was explored on organic matrixes and grafted polymers. DFT analysis provided a rationale for the role of the coordination core. The antibacterial response of the two series of hybrid polymers was tested against the total coliform group of untreated urban wastewater, revealing excellent inactivation ability.

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Theory and experiment: The synthesis and drug application of “ON-OFF-ON” fluorescent probes for copper and biothiols detection

Liu,

Hao

et al. 2024

Journal of Pharmaceutical and Biomedical Analysis

8

0

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AIEgen orthopalladated hybrid polymers for efficient inactivation of the total coliforms in urban wastewater

Sessa,

Diana,

Gentile

et al. 2023

Sci Rep

1

0

View full text Add to dashboard Cite

Monitorable AIE polymers with a bioactive pattern are employed in advanced biomedical applications such as functional coatings, theranostic probes, and implants. After the global COVID-19 pandemic, interest in developing surfaces with superior antimicrobial, antiproliferative, and antiviral activities dramatically increased. Many formulations for biocide surfaces are based on hybrid organic/inorganic materials. Palladium (II) complexes display relevant activity against common bacteria, even higher when compared to their uncoordinated ligands. This article reports the design and synthesis of two series of orthopalladated polymers obtained by grafting a cyclopalladated fragment on two different O, N chelating Schiff base polymers. Different grafting percentages were examined and compared for each organic polymer. The fluorescence emission in the solid state was explored on organic matrixes and grafted polymers. DFT analysis provided a rationale for the role of the coordination core. The antibacterial response of the two series of hybrid polymers was tested against the total coliform group of untreated urban wastewater, revealing excellent inactivation ability.

show abstract

A water-soluble fluorescent probe for monitoring mitochondrial GSH fluctuations during oxidative stress

Abstract: In this research, we constructed a styrylpyridine derivative-based fluorescent probe MITO-PQDNs to monitor mitochondrial glutathione (GSH).

Cited by 3 publications

References 40 publications

AIEgen orthopalladated hybrid polymers for efficient inactivation of the total coliforms in urban wastewater

AIEgen orthopalladated hybrid polymers for efficient inactivation of the total coliforms in urban wastewater

Theory and experiment: The synthesis and drug application of “ON-OFF-ON” fluorescent probes for copper and biothiols detection

AIEgen orthopalladated hybrid polymers for efficient inactivation of the total coliforms in urban wastewater

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