A water-soluble turn-on fluorescent probe for rapid discrimination and imaging of Cys/Hcy and GSH in cells and zebrafish through different fluorescent channels

A lysosome-targeted fluorescent probe based on a BODIPY structure for Cys/Hcy detection

“…They play an important role in the regulation of cellular redox processes and ensuring normal operation of physiological activities. [1][2][3] An abnormal Cys concentration can increase the risk of some diseases including slow growth in children, cardiovascular disease, hair bleaching, skin damage and so on. [4][5][6][7][8][9][10][11][12] Hcy is a non-protein amino acid that can be broken down into Cys by a sulfurization reaction.…”

A Near-Infrared Fluorescent Dye with Tunable Emission Wavelength and Stokes Shift as a High-Sensitivity Cysteine Nanoprobe for Monitoring Ischemic Stroke

“…Furthermore, in the process of monitoring Cys, both glutathione (GSH) and homocysteine (Hcy) may interfere with Cys, because they have similar structures. The specificity to identify Cys is still challenging. − Therefore, the development of an NIR fluorescent probe that specifically identifies Cys is of great importance for the accurate diagnosis of ischemic stroke and other related diseases.…”

A water-soluble fluorescent probe for monitoring mitochondrial GSH fluctuations during oxidative stress

“…20,22 Furthermore, the pyridine salt moiety with a positive charge could bind tightly to the inner mitochondrial membrane with a negative potential of −180 mV, which allowed the probe MITO-PQDNs to be selectively enriched in mitochondria. 23–28 However, most of the available pyridinium probes had small Stokes shifts, resulting in strong self-absorption which would be detrimental to fluorescence imaging applications. In comparison, MITO-PQDNs could react rapidly with GSH in PBS buffer, thus showing intense yellow fluorescence (586 nm) as well as significant Stokes shift (200 nm).…”