A whole animal-based biosensor for fast detection of bitter compounds using extracellular potentials in rat gustatory cortex

Qin, Zhen; Zhang, Bin; Gao, Keqiang; Zhuang, Liujing; Hu, Ning; Wang, Ping

doi:10.1016/j.snb.2016.08.027

Cited by 18 publications

(8 citation statements)

References 40 publications

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“…Biosensors based on animal mammalian gustatory systems provide a whole sensing strategy for bitterness detection without requiring complex microelectronic array modification [ 113 ]. For instance, Qin and colleagues constructed a biosensor using a rat mammalian gustatory system for bitterness detection ( Figure 3 ) [ 114 ]. After brain surgery, a 16-channel microelectronic array was inserted to anesthetic rats’ dura and stabilized with a dental acrylic resin.…”

Section: Microminiaturized Biosensors For Bitterness Detectionmentioning

confidence: 99%

“…( A ) Scheme of a rat gustatory system and the taste information pathway from taste buds via brain stem to microwire electrodes; ( B ) the microelectrode array employed in biosensor; ( C ) the schematic diagram of the whole animal-based biosensor; ( D ) the test order of different taste deliveries. Reproduced from [ 114 ] with permission from Elsevier.…”

Section: Figurementioning

confidence: 99%

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Recent Advances in Bitterness-Sensing Systems

Langley

Zhang

2023

Biosensors

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Bitterness is one of the basic tastes, and sensing bitterness plays a significant role in mammals recognizing toxic substances. The bitter taste of food and oral medicines may decrease consumer compliance. As a result, many efforts have been made to mask or decrease the bitterness in food and oral pharmaceutical products. The detection of bitterness is critical to evaluate how successful the taste-masking technology is, and many novel taste-sensing systems have been developed on the basis of various interaction mechanisms. In this review, we summarize the recent progress of bitterness response mechanisms and the development of novel sensors in detecting bitterness ranging from commercial electronic devices based on modified electrodes to micro-type sensors functionalized with taste cells, polymeric membranes, and other materials in the last two decades. The challenges and potential solutions to improve the taste sensor quality are also discussed.

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Section: Microminiaturized Biosensors For Bitterness Detectionmentioning

confidence: 99%

Section: Figurementioning

confidence: 99%

Recent Advances in Bitterness-Sensing Systems

Langley

Zhang

2023

Biosensors

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“…However, motion artifacts would generate when local field potentials were detected in the wake state of before and after bitter stimulation. Their work detected local field potentials in the rat’s anesthesia states and achieved high sensitivity detection and high specificity screening of bitter compounds [ 103 ].…”

Section: Various Biomimetic Olfactory and Gustatory Biosensorsmentioning

confidence: 99%

Progress in the Development of Detection Strategies Based on Olfactory and Gustatory Biomimetic Biosensors

Chen

Tian

et al. 2022

Biosensors

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The biomimetic olfactory and gustatory biosensing devices have broad applications in many fields, such as industry, security, and biomedicine. The development of these biosensors was inspired by the organization of biological olfactory and gustatory systems. In this review, we summarized the most recent advances in the development of detection strategies for chemical sensing based on olfactory and gustatory biomimetic biosensors. First, sensing mechanisms and principles of olfaction and gustation are briefly introduced. Then, different biomimetic sensing detection strategies are outlined based on different sensing devices functionalized with various molecular and cellular components originating from natural olfactory and gustatory systems. Thereafter, various biomimetic olfactory and gustatory biosensors are introduced in detail by classifying and summarizing the detection strategies based on different sensing devices. Finally, the future directions and challenges of biomimetic biosensing development are proposed and discussed.

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“…These types of bioelectronic noses have certain decisive advantages over traditional electronic noses with regard to odorant detection, including functioning at room temperature, high sensitivity, and good selectivity . Among various bioelectronic noses, animal-based ones have much more stable performance, longer lifetimes, and more complete information processing systems, which makes them valuable in developing reliable and portable odorant detection systems. − In addition, rapid technological developments in the field of brain–computer interfaces will also promote the application of whole organism-based bioelectronic noses in many fields.…”

Section: Introductionmentioning

confidence: 99%

In Vivo Bioelectronic Nose Based on a Bioengineered Rat Realizes the Detection and Classification of Multiodorants

Zhu

Liu

Tian

et al. 2022

ACS Chem. Neurosci.

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Inspired by the powerful capability of the biological olfactory system, we developed an in vivo bioelectronic nose based on a bioengineered rat by recording electrophysiological-responsive signals from the olfactory bulb with implanted multichannel microelectrodes. The bioengineered rat was prepared by overexpressing a selected olfactory receptor (OR3) on the rat olfactory epithelium, and multichannel electrophysiological signals were obtained from the mitral/tufted (M/T) cell population of the olfactory bulb. The classification of target multiodorants was realized by analyzing the redundant stimuli-responsive firing information. Ligand odorants induced significant firing changes with specific response patterns compared with nonligand odorants. The responsive curves were dependent on the concentration of target ligand odorants ranging from 10–6 to 10–3 M, and the detection limit was as low as 10–5 M. In addition, different ligand odorants were successfully discriminated via principal component analysis. This in vivo bioelectronic nose provides a novel approach for the detection of specific target odorants and has promising application potential in the field of rapid on-site odor discrimination.

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A whole animal-based biosensor for fast detection of bitter compounds using extracellular potentials in rat gustatory cortex

Cited by 18 publications

References 40 publications

Recent Advances in Bitterness-Sensing Systems

Recent Advances in Bitterness-Sensing Systems

Progress in the Development of Detection Strategies Based on Olfactory and Gustatory Biomimetic Biosensors

In Vivo Bioelectronic Nose Based on a Bioengineered Rat Realizes the Detection and Classification of Multiodorants

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