2023
DOI: 10.1101/2023.12.12.570949
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A yeast modular cloning (MoClo) toolkit expansion for optimization of heterologous protein secretion and surface display inSaccharomyces cerevisiae

Nicola M. O’Riordan,
Vanja Jurić,
Sarah K. O’Neill
et al.

Abstract: Saccharomyces cerevisiaeis an attractive host for expression of secreted proteins in a biotechnology context. Unfortunately, many heterologous proteins fail to enter, or efficiently progress through, the secretory pathway, resulting in poor yields. Similarly, yeast surface display has become a widely used technique in protein engineering but achieving sufficient levels of surface expression of recombinant proteins is often challenging. Signal peptides (SPs) and translational fusion partners (TFPs) can be used … Show more

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