A yellow-emitting nitrogen-doped carbon dots for sensing of vitamin B12 and their cell-imaging

Sun, Zishan; Chen, Zikang; Luo, Juan; Zhu, Zhenpeng; Zhang, Xinguo; Liu, Ruiyuan; Wu, Zhan‐Chao

doi:10.1016/j.dyepig.2020.108227

Cited by 36 publications

(12 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover FT-IR spectrum of NA-CQDs exhibited characteristic absorption peaks at around 1659 and 1700 cm − 1 which are belong to C = C and C = O stretching vibrations bands. Furthermore, nicotinamide had been successfully functionalized on the carbon quantum dots due to the appearance of bending vibration of C-NH and stretching vibration of C-N at 1380 and 1550 cm − 1 , respectively [4,25]. The results obtained from FT-IR are in agreement with other characterization and clearly con rm that nicotinamide-functionalized CQDs are successfully synthesized.…”

Section: Ft-irsupporting

confidence: 80%

See 1 more Smart Citation

Nicotinamide-Functionalized Carbon Quantum Dot as New Sensing Platform for Portable Quantification of Vitamin B12 in Fluorescence, UV–Vis and Smartphone Triple Mode

et al. 2022

View full text Add to dashboard Cite

Development of an e cient, portable and simple nanosensor-based systems with reliable analytical performance for on-site monitoring of vitamin B12 (VB12) are still major problems and a challenging work for quality control of manufacturers. Herein, a new uorescence, UV-Vis and smartphone triple mode nanosensors were designed for the simultaneous detection of VB12 with high sensitivity and accuracy. A novel nanosensor was synthesized through nicotinamide-functionalizing on carbon quantum dot (NA-CQDs) by an one-step microwave-assisted method with green approaches. The NA-CQDs as new nanosensor showed excellent uorescence properties and wide linear ranges from 0.1-60 µM with the detection limits of 31.7 nM. Moreover, color changes of NA-CQDs induced by the VB12 could also be detected by UV-Vis spectrophotometer and inhouse-developed application installed on smartphone as a signal reader, simultanusly. The Red, Green and Blue (RGB) intensities of the colorimetric images of NA-CQDs/VB12 system which taken by smartphone's camera converted into quantitative values by the introduced application. A smartphone-integrated with NA-CQDs as colorimetric sensing platform displays good linear ranges (4.16 to 66.6 µM) for on-site determination of VB12 with detection limit of 1.40 µM.The method was successfully applied in the determination of VB12 in complex pharmaceutical supplement formulations without any sample pre-treatment and matrix interfering effects. The recovery results (96.52-105.10%) which are in agreement with the reference methods, demonstrating the capability of the smartphone-assisted colorimetric sensing platform in many on-site practical applications of quality controls.

show abstract

Section: Ft-irsupporting

confidence: 80%

“…Vitamin B12 (VB12), also called as cyanocobalamin, plays a vital role in normal metabolism of enzymes, lipids and carbohydrates, nerve cell maintenance, DNA synthesis and red blood cell formation [1][2][3][4]. For adults, the recommended dietary allowance of VB12 are about 0.40-2.80 mg per day [5].…”

Section: Introductionmentioning

confidence: 99%

Nicotinamide-Functionalized Carbon Quantum Dot as New Sensing Platform for Portable Quantification of Vitamin B12 in Fluorescence, UV–Vis and Smartphone Triple Mode

et al. 2022

View full text Add to dashboard Cite

show abstract

“…19 A variety of precursors have been used to synthesize CDs hydrothermally or solvothermally, such as carbohydrates, 20 proteins, 21,22 and many organic acids including amino acids and citric acids. [23][24][25][26] Meanwhile, ultrasonication represents a gentler method compared with microwave irradiation or hydrothermal/solvothermal approaches, although examples of this technique are rare. 27 For example, Zhou et al reported a unique type of excitation-independent yellow-emissive CDs (Y-CDs) with citric acid and o-phenylenediamine (OPD) applied as precursors.…”

Section: Carbon Dotsmentioning

confidence: 99%

Carbon Dots: A Future Blood–Brain Barrier Penetrating Nanomedicine and Drug Nanocarrier

Zhang

Sigdel

Mintz

et al. 2021

IJN

View full text Add to dashboard Cite

Drug delivery across the blood–brain barrier (BBB) is one of the biggest challenges in modern medicine due to the BBB’s highly semipermeable property that limits most therapeutic agents of brain diseases to enter the central nervous system (CNS). In recent years, nanoparticles, especially carbon dots (CDs), exhibit many unprecedented applications for drug delivery. Several types of CDs and CD-ligand conjugates have been reported successfully penetrating the BBB, which shows a promising progress in the application of CD-based drug delivery system (DDS) for the treatment of CNS diseases. In this review, our discussion of CDs includes their classification, preparations, structures, properties, and applications for the treatment of neurodegenerative diseases, especially Alzheimer’s disease (AD) and brain tumor. Moreover, abundant functional groups on the surface, especially amine and carboxyl groups, allow CDs to conjugate with diverse drugs as versatile drug nanocarriers. In addition, structure of the BBB is briefly described, and mechanisms for transporting various molecules across the BBB and other biological barriers are elucidated. Most importantly, recent developments in drug delivery with CDs as BBB-penetrating nanodrugs and drug nanocarriers to target CNS diseases especially Alzheimer’s disease and brain tumor are summarized. Eventually, future prospects of the CD-based DDS are discussed in combination with the development of artificial intelligence and nanorobots.

show abstract

“…CDs are zero-dimensional and sphere-shaped nanoparticles possessing diameters less than 10 nm [63,64]. Various approaches have been applied for preparing diverse types of CDs, e.g., laser ablation [65], solvothermal [66], hydrothermal synthesis [67], microwave-assisted [68], arc discharge [69], acidic oxidation [70], and more chemical and physical approaches [71,72]. Additionally, CDs display a desirable prospect for various applications, such as biological imaging [73], chemical and biosensing [74][75][76][77], targeted drug delivery [78], pharmaceutical analysis [79], and catalysis [80,81].…”

Section: Carbon Dots As Nanothermometersmentioning

confidence: 99%

Carbon Dots as New Generation Materials for Nanothermometer: Review

Mohammed

Omer

2020

Nanoscale Res Lett

View full text Add to dashboard Cite

Highly sensitive non-contact mode temperature sensing is substantial for studying fundamental chemical reactions, biological processes, and applications in medical diagnostics. Nanoscale-based thermometers are guaranteeing non-invasive probes for sensitive and precise temperature sensing with subcellular resolution. Fluorescence-based temperature sensors have shown great capacity since they operate as “non-contact” mode and offer the dual functions of cellular imaging and sensing the temperature at the molecular level. Advancements in nanomaterials and nanotechnology have led to the development of novel sensors, such as nanothermometers (novel temperature-sensing materials with a high spatial resolution at the nanoscale). Such nanothermometers have been developed using different platforms such as fluorescent proteins, organic compounds, metal nanoparticles, rare-earth-doped nanoparticles, and semiconductor quantum dots. Carbon dots (CDs) have attracted interest in many research fields because of outstanding properties such as strong fluorescence, photobleaching resistance, chemical stability, low-cost precursors, low toxicity, and biocompatibility. Recent reports showed the thermal-sensing behavior of some CDs that make them an alternative to other nanomaterials-based thermometers. This kind of luminescent-based thermometer is promising for nanocavity temperature sensing and thermal mapping to grasp a better understanding of biological processes. With CDs still in its early stages as nanoscale-based material for thermal sensing, in this review, we provide a comprehensive understanding of this novel nanothermometer, methods of functionalization to enhance thermal sensitivity and resolution, and mechanism of the thermal sensing behavior.

show abstract

A yellow-emitting nitrogen-doped carbon dots for sensing of vitamin B12 and their cell-imaging

Cited by 36 publications

References 36 publications

Nicotinamide-Functionalized Carbon Quantum Dot as New Sensing Platform for Portable Quantification of Vitamin B12 in Fluorescence, UV–Vis and Smartphone Triple Mode

Nicotinamide-Functionalized Carbon Quantum Dot as New Sensing Platform for Portable Quantification of Vitamin B12 in Fluorescence, UV–Vis and Smartphone Triple Mode

Carbon Dots: A Future Blood–Brain Barrier Penetrating Nanomedicine and Drug Nanocarrier

Carbon Dots as New Generation Materials for Nanothermometer: Review

Contact Info

Product

Resources

About