A YIPF5-GOT1A/B complex directs a transcription-independent function of ATF6 in ER export
Paul Cramer,
Yoji Yonemura,
Laura Behrendt
et al.
Abstract:Exit from the endoplasmic reticulum is mediated by the Sar1/COPII machinery and a number of accessory factors. How the initial steps of cargo recruitment upstream of Sar1/COPII are mediated remains unclear, but the dihydropyridine FLI-06 inhibits cargo recruitment into ER exit sites. Here, we used chemical genetics screening approaches in conjunction with FLI-06 treatment and identified the ER membrane proteins YIPF5 and GOT1A/B as putative components of early export processes. Surprisingly, the two homologous… Show more
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