A Young Man With Acute Kidney Injury and Uveitis: An Unusual Presentation and Case Report

Abstract

Tubulointerstitial nephritis with uveitis (TINU) is an uncommon autoimmune syndrome that involves multiple systems. It usually presents with acute kidney injury (AKI) and unilateral or bilateral uveitis. We present a 15-year-old male, fit and well, who attended emergency room (ER) with a four-month history of epigastric pain associated with nausea, vomiting, and weight loss of 10 kg. Initial clinical and laboratory evaluation confirmed AKI. A diagnostic kidney biopsy confirmed acute tubulointerstitial nephritis, and a slit-lamp examination confirmed acute left anterior uveitis consistent with a diagnosis of TINU. He was initially treated with corticosteroids which resulted in prompt resolution of AKI; however, uveitis persisted necessitating the addition of further immunosuppressants.