A zwitterionic silver nanoparticle-incorporating injectable hydrogel with a durable and efficient antibacterial effect for accelerated wound healing

Xiang, Jun; Bai, Yangjing; Huang, Ying-Chun; Lang, Shiying; Li, Juan; Ji, Ying; Peng, Biyu; Liu, Gongyan

doi:10.1039/d2tb01493a

Cited by 20 publications

(15 citation statements)

References 59 publications

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“…As a drug carrier or antibacterial active substance, nanoparticles are applied to skin damage repair by mixing with hydrogel to form composite hydrogel (Sun et al, 2021;Burdusel et al, 2022;Qin P. et al, 2022). Silver particles, titanium oxide, gentamicin-containing nanoparticles, curcumincontaining nanoparticles, and other composite hydrogels have been confirmed to have anti-bacterial and wound healing-promoting effects (Javanmardi et al, 2018;Zahiri et al, 2020;Xiang et al, 2022). In recent years, gallium ion has been found to be advantageous in the field of antibacterial materials (Vinuesa and McConnell, 2021).…”

Section: Discussionmentioning

confidence: 99%

Gallium-modified gelatin nanoparticles loaded with quercetin promote skin wound healing via the regulation of bacterial proliferation and macrophage polarization

Yang

Shi

Zhou

et al. 2023

Front. Bioeng. Biotechnol.

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Background: Wound healing is a complicated process involving multiple cell components and can help the re-establishment of the skin’s barrier function. Previous studies have pointed out that bacterial infection and sustained inflammatory reactions are the main causes of the delay of wound closure and scar formation during wound healing. The effect of current approaches for scar-free wound repair still faces many challenges, and alternative therapeutic methods are urgently needed to be established.Methods: The basic characteristics of the new-designed nanoparticles were clarified through the characterization of the material. The biocompatibility of the nanoparticles, as well as its effect on fibroblast function, anti-bacterial capacity, inflammation suppressive role, and the underlying mechanism were further verified by a panel of biochemical assays in vitro. Ultimately, pre-clinical rat model was employed to testify its role in wound healing and scar formation in vivo.Results: Firstly, gallium-modified gelatin nanoparticles loaded with quercetin was successfully established, displaying good biocompatibility and facilitative effect on fibroblast function. In addition, the nanoparticles showed prominent anti-bacterial and inflammation-suppressive effects. What’s more important, the nanoparticles could also induce the polarization of macrophages from M1 to M2 phenotype to exert its inflammatory inhibitory role through TGF-β/Smad signaling pathway. Ultimately, in vivo experiment showed that the nanoparticles could effectively promote wound repair and inhibit scar formation during the process of wound healing.Conclusion: Taken together, the new nanoparticles have good anti-bacterial and anti-scar formation effects and great potential in the field of skin wound repair, which provides a promising therapeutic strategy for wound treatment.

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Section: Discussionmentioning

confidence: 99%

Gallium-modified gelatin nanoparticles loaded with quercetin promote skin wound healing via the regulation of bacterial proliferation and macrophage polarization

Yang

Shi

Zhou

et al. 2023

Front. Bioeng. Biotechnol.

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“…The obtained red blood cells were then diluted in 50 mL of saline solution (2.4 v/v %). 26 To test the hemolysis rate of GS, Celox, and GPZ sponges, diluted red blood cells were added to the surface of the sponge. Red cell suspensions treated with deionized water and normal saline were used as positive and negative controls, respectively.…”

Section: Methodsmentioning

confidence: 99%

Gelatin Sponges with a Uniform Interoperable Pore Structure and Biodegradability for Liver Injury Hemostasis and Tissue Regeneration

Du,

Bai,

Lang

et al. 2023

Biomacromolecules

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Developing a hemostatic sponge that can effectively control bleeding from visceral injuries while guiding in situ tissue regeneration in incompressible wounds remains a challenge. Most of the existing hemostatic sponges degrade slowly, are relatively single-functioning, and cannot cope with complex environments. Herein, a biodegradable rapidly hemostatic sponge (GPZ) was created by dual-dynamic-bond cross-linking among Zn2+, protocatechualdehyde (PA)-containing catechol and aldehyde groups, and gelatin. GPZ had a uniformly distributed interconnected pore structure with excellent fluid absorption. It could effectively absorb the oozing blood and increase the blood concentration while stimulating platelet activation and accelerating blood coagulation. Compared to commercial hemostats, GPZ treatment significantly accelerated hemostasis in the rat liver defect model (∼0.33 min, ≥50% reduction in the hemostatic time) and in the rabbit liver defect model (∼1.02 min, ≥60% reduction in the hemostatic time). Additionally, GPZ had excellent antibacterial and antioxidant properties that effectively protected the wound from infection and excessive inflammation. In the liver regeneration model, GPZ significantly increased the rate of hepatic tissue repair and promoted rapid functional recovery without complications and adverse reactions. Overall, we designed a simple and effective biodegradable rapid hemostatic sponge with good clinical translational potential for treating lethal incompressible bleeding and promoting wound healing.

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“…The antibacterial eye drops ZP@Ag-drops were synthesized based on our previous research. 32 In brief, 1.96 mg mL −1 PSBDA copolymer was fully dissolved in 50 mL deionized (DI) water at 60 °C, while 0.63 mg mL −1 AgNO 3 was dissolved in another 50 mL DI water in the dark. Then the AgNO 3 solution was added dropwise ito the PSBDA solution for 10 min under dark conditions.…”

Section: Methodsmentioning

confidence: 99%

“…31 In our previous work, we successfully synthesized zwitterionic polymer-modified AgNPs (ZP@Ag) in a one-step process using poly(sulfobetaine methacrylate- co -dopamine methacrylamide) (PSBDA) as both the stabilizing and reducing agents. 32 The zwitterionic outer layers of ZP@Ag enable the formation of a hydration layer on the surface, preventing nanoparticle aggregation, precipitation, or clearance in physical environments. 33 This property ensures good dispersion stability in saline and liquid bacterial nutrient broth for up to 7 days.…”

Section: Introductionmentioning

confidence: 99%

Zwitterionic silver nanoparticle based antibacterial eye drops for efficient therapy of bacterial keratitis

Bai,

Ma,

Huang

et al. 2023

Biomater. Sci.

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A zwitterionic silver nanoparticle-incorporating injectable hydrogel with a durable and efficient antibacterial effect for accelerated wound healing

Abstract: Antibacterial wound dressing is essential for inflammation control and accelerated wound healing. This study investigates polyzwitterion-functionalized silver nanoparticles (AgNPs) with enhanced antibacterial performance in an injectable wound dressing hydrogel. A...

Cited by 20 publications

References 59 publications

Gallium-modified gelatin nanoparticles loaded with quercetin promote skin wound healing via the regulation of bacterial proliferation and macrophage polarization

Gallium-modified gelatin nanoparticles loaded with quercetin promote skin wound healing via the regulation of bacterial proliferation and macrophage polarization

Gelatin Sponges with a Uniform Interoperable Pore Structure and Biodegradability for Liver Injury Hemostasis and Tissue Regeneration

Zwitterionic silver nanoparticle based antibacterial eye drops for efficient therapy of bacterial keratitis

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