2021
DOI: 10.3389/fcvm.2021.761164
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A2 Adenosine Receptor Subtypes Overproduction in Atria of Perioperative Atrial Fibrillation Patients Undergoing Cardiac Surgery: A Pilot Study

Abstract: Objective: Although atrial fibrillation is a common cardiac arrhythmia in humans, the mechanism that leads to the onset of this condition is poorly elucidated. Adenosine is suspected to be implicated in the trigger of atrial fibrillation (AF) through the activation of its membrane receptors, mainly adenosine receptor (AR) subtypes A1R and A2R. In this study, we compared blood adenosine concentration (BAC), and A1R, A2AR, and A2BR production in right (RA) and left atrium (LA), and on peripheral blood mononuclea… Show more

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Cited by 3 publications
(6 citation statements)
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“…Interestingly, while high A 2A R and high ABL in VVS seem to participate in the cause of the disease, since high A 2A production and a specific polymorphism in A 2A R gene are associated with VVS suggesting a genetic predisposition [ 35 ], the increase in these parameters in CCF or in cardiogenic shock seems rather an adaptive mechanism. Both high ABL and A 2B R overproduction have been reported in patients with atrial fibrillation (AF) [ 36 ]. However, if the increase in A 2B production participates in the AF process or if conversely it is an adaptive mechanism that remains unknown.…”
Section: Discussionmentioning
confidence: 99%
“…Interestingly, while high A 2A R and high ABL in VVS seem to participate in the cause of the disease, since high A 2A production and a specific polymorphism in A 2A R gene are associated with VVS suggesting a genetic predisposition [ 35 ], the increase in these parameters in CCF or in cardiogenic shock seems rather an adaptive mechanism. Both high ABL and A 2B R overproduction have been reported in patients with atrial fibrillation (AF) [ 36 ]. However, if the increase in A 2B production participates in the AF process or if conversely it is an adaptive mechanism that remains unknown.…”
Section: Discussionmentioning
confidence: 99%
“…A 2B Rs are expressed in coronary arteries and mediates coronary vasodilation, with a minor and supportive role compared to A 2A R [ 50 ]. The expression of A 2B Rs has also been reported in atrial and ventricular cardiomyocytes [ 35 , 47 ]. A 2B Rs’ activation on cardiac fibroblasts reduces collagen and total protein synthesis suggesting that adenosine may protect against cardiac fibrosis [ 51 ].…”
Section: Adenosinergic System Signalingmentioning
confidence: 99%
“…This is especially useful as a cardioprotection in ischemia-reperfusion injury [ 41 , 42 ]. A 2A Rs are particularly expressed in vessels and coronary arteries with a vasodilator effect [ 43 , 44 ], whereas their density is moderate in ventricular and atrial tissues, leading to the contraction of cardiomyocytes [ 45 , 46 , 47 ]. Opposite to A 1 R, A 2A R directly enhanced the inotropic effect of cardiomyocyte by increasing the cytosolic Ca 2+ level and the Ca 2+ sensitivity of the myofilaments [ 48 ].…”
Section: Adenosinergic System Signalingmentioning
confidence: 99%
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