A7RC peptide modified paclitaxel liposomes dually target breast cancer

Abstract

A7R peptide (ATWLPPR), a ligand of the NRP-1 receptor, regulates the intracellular signal transduction related to tumor vascularization and tumor growth. Here, we designed A7R-cysteine peptide (A7RC) surface modified paclitaxel liposomes (A7RC-LIPs) to achieve targeting delivery and inhibition of tumor growth and angiogenesis simultaneously. The cytotoxicity, inhibiting angiogenesis, and internalization of various liposomes by cells were assessed in vitro to confirm the influence of the peptide modification. The accumulations of A7RC-LIPs in various xenografts in mice were tracked to further identify the function of the peptide on the liposomes' surface. The results confirmed that A7RC peptides could enhance the uptake of vesicles by MDA-MB-231 cells, leading to stronger cytotoxicity in vitro and higher accumulation of vesicles in MDA-MB-231 xenografts in vivo. In addition, A7RC peptides enhanced the inhibitory effects of LIPs on the HUVEC tubular formation on Matrigel. The A7RC-LIPs may be promising drug carriers for anticancer therapy.

Sustained release of anticancer agent phytic acid from its chitosan-coated magnetic nanoparticles for drug-delivery system

“…These nanocomposites are widely used as nanodelivery systems that enhance the biodistribution of drugs and selectively target diseased tissues while protecting healthy tissues. 1,2 Various nanocarriers including liposomes, [3][4][5][6] cell-based nanocarriers, 7 polymers, 8 carbon materials, 9,10 dendrimers, 11 and inorganic nanoparticles 12,13 have been employed for gene and drug delivery systems, which have shown efficacy both in vitro and in vivo. Recently, much attention has been devoted to polymer-based nanoparticles (…”

Encapsulation of Anticancer Drugs (5-Fluorouracil and Paclitaxel) into Polycaprolactone (PCL) Nanofibers and In Vitro Testing for Sustained and Targeted Therapy

“…17–21 Nanostructures, both inorganic and organic materials, have unique chemical, physical, and biological functions, and have been extensively studied as biomaterials or bio-functional materials. 22–26 …”

A Multifunctional Biodegradable Nanocomposite for Cancer Theranostics

“…2019, 6, 1802001 chemotherapeutic properties of PTX. [46] However, no significant body weight changes were observed with any of the other treatments (Figure 7c), indicating the biocompatibility of the materials. Mice given free ICG and NIR showed only a small reduction in tumor volume when compared to the saline group.…”