Ab0277 what Is the Link Between Lung Involvement and Anti-CCP Antibodies in Rheumatoid Arthritis: A Retrospective Study

Abstract

BackgroundRheumatoid arthritis (RA) is chronic inflammatory rheumatism responsible for joint destruction and also a systemic disease. Pulmonary involvement is one of the most common extra-articular manifestations of RA and it is associated with a poor prognosis. Several studies have demonstrated an association between the occurrence of RA and the positivity of anti-cyclic citrullinated peptide antibodies (anti-CCP), an immunological biomarker that is used to evaluate the disease activity in RA patients.ObjectivesThe objective of this study was to investigate the link between anti-CCP and lung damage in patients with RA.MethodsThe study was a retrospective analysis that included 407 patients who were followed for RA between January 2011 and March 2022. Data were collected from the medical records of the patients, and analyzed using statistical test such chi-squared, Fisher’s exact test and t-test. The level of significance was set at p=0.05.The study design included a thorough data cleaning process.ResultsThe mean age of patients (n=407) was 58.86 years ± 12.441 with a sex ratio of 6 (F/M). The median duration of evolution was 14 ± 7.523 years, 16% of patients were hypertensive and 19.5% were diabetic RA was erosive in 87.2% of patients, rheumatoid factor (RF) was positive in 85% of patients, and anti-CCP was positive in 64.9% of patients. The mean RF level was 165.8982 ± 278.49, and the mean anti-CCP level was 224.26 ± 440.18. Pulmonary involvement was present in 14.5% of patients, with a restrictive pattern seen on pulmonary function tests in 40.4% of cases, and rheumatoid nodules, diffuse interstitial lung disease lesions, and bronchiectasis seen on thorax CT scan in 67.2%, 31.6%, and 25.9% of cases respectively. The study found that anti-CCP was positive in 96.6% of patients with lung involvement, compared to those without lung involvement, with a statistically significant difference (p<0.001). This suggests that a high anti-CCP level may be a risk factor for pulmonary involvement in RA patients.ConclusionThe study demonstrated the positive association between anti-CCP and the existence of pulmonary involvement in RA, which is consistent with data from the literature. It’s important to note that this study is a retrospective one and further studies with larger population and different design are needed to validate the findings.REFERENCES:NIL.Acknowledgements:NIL.Disclosure of InterestsNone Declared.