AB0758 The Relationships between Bone Mineral Density and Radiographic Features of Hand or Knee Osteoarthritis in Older Adults: Data from The Dong-Gu Study

Abstract

ObjectivesThe relationship between osteoarthritis (OA) and osteoporosis has exhibited contradictory features over the past four decades. The aim of this study was to evaluate this relationship using separate analysis of the radiographic features of OA whether various radiographic features of OA were associated differently with bone mineral density (BMD) in the Korean elderly.MethodsData were derived from the Dong-gu cohort; 2,354 subjects were enrolled in the present cross-sectional study. Baseline characteristics, the BMDs of the lumbar spine and femoral neck which was measured by DXA, and X-rays of knees and hands, were collected. A semi-quantitative grading system was used to estimate the severities of individual radiographic features. We adjusted for confounders using multiple linear regression modeling to analyze the relationships.ResultsAfter adjustment for confounders, hand and knee OA total scores were negatively associated with the BMDs of the lumbar spine and femoral neck, except for the total knee OA score and lumbar spine BMD. In detail, hand osteophytes and sclerosis exhibited positive relationships with the BMDs of the lumbar spine and femoral neck, except for hand osteophytes and femoral neck BMD. On the contrary, however, knee joint space narrowing (JSN), hand JSN, and hand subchondral cysts were negatively associated with the BMD of the lumbar spine and femoral neck. Knee JSN and hand subchondral cysts exerted the greatest effects on BMD.ConclusionsSeparate analysis of the radiographic features of OA better reveals associations of OA with the BMD of the lumbar spine and femoral neck.Disclosure of InterestNone declared

Decrease in Local Volumetric Bone Mineral Density in Osteoarthritic Joints Is Associated with the Increase in Cartilage Damage: A Peripheral Quantitative CT Study

“…This was also accompanied by a faster BMD loss compared with healthy controls. Conversely, Lee et al (2016) observed that hand and knee OA were negatively associated with the BMDs of the lumbar spine and femoral neck.…”

“…DXA provides a reliable evaluation of areal bone density but is incapable of distinguishing between cortical and trabecular bone (the parameter measured and discussed in this article) or take into account changes in the bone size, which may overestimate the resultant BMD, whereas pQCT can provide accurate measurements of true vBMD and can supply isolated measurement of cortical and trabecular bones (Abdin-Mohamed et al, 2009). As such, although radiographic OA of the knee is known to be connected to elevated areal BMD at the hip and spine, the vBMD of tibia was not increased in patients with knee OA (Lee et al, 2016).…”