2014
DOI: 10.1128/mbio.01076-14
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AB5075, a Highly Virulent Isolate of Acinetobacter baumannii, as a Model Strain for the Evaluation of Pathogenesis and Antimicrobial Treatments

Abstract: Acinetobacter baumannii is recognized as an emerging bacterial pathogen because of traits such as prolonged survival in a desiccated state, effective nosocomial transmission, and an inherent ability to acquire antibiotic resistance genes. A pressing need in the field of A. baumannii research is a suitable model strain that is representative of current clinical isolates, is highly virulent in established animal models, and can be genetically manipulated. To identify a suitable strain, a genetically diverse set … Show more

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Cited by 279 publications
(320 citation statements)
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“…Its MDR phenotype and recent isolation make it more representative of current outbreak strains than older type strains often used in experimental studies (28). In addition, AB5075 displays robust virulence in multiple animal models and is amenable to genetic manipulation, making it a promising model strain for analysis of a variety of traits (28).…”
Section: Discussionmentioning
confidence: 99%
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“…Its MDR phenotype and recent isolation make it more representative of current outbreak strains than older type strains often used in experimental studies (28). In addition, AB5075 displays robust virulence in multiple animal models and is amenable to genetic manipulation, making it a promising model strain for analysis of a variety of traits (28).…”
Section: Discussionmentioning
confidence: 99%
“…Its MDR phenotype and recent isolation make it more representative of current outbreak strains than older type strains often used in experimental studies (28). In addition, AB5075 displays robust virulence in multiple animal models and is amenable to genetic manipulation, making it a promising model strain for analysis of a variety of traits (28). part of the diagram represent log 2 -transformed normalized read counts per insertion site (counts averaged from the six technical replicates), with bars above or below the line reflecting insertion in forward or reverse orientation relative to the genome, respectively.…”
Section: Discussionmentioning
confidence: 99%
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“…A. baumannii strain AB5075 (26) and an isogenic abaI::Tc mutant were obtained from Colin Manoil at the University of Washington. Strains ATCC 17978, AB1712, and AB0057 (27,28) were obtained from Robert Bonomo at Case Western Reserve University.…”
Section: Methodsmentioning
confidence: 99%