ABCB1 variants confer susceptibility to primary open-angle glaucoma and predict individual differences to latanoprost treatment

Hai, Liu; Yang, Zhimin; Li, Yan; Zhang, Wenjia; Wang, Ying-Ting; Duan, Xuanchu

doi:10.1016/j.biopha.2016.02.028

Cited by 14 publications

(16 citation statements)

References 37 publications

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“…Similarly, an OATP2A1 genetic variant (rs4241366) was found to have some correlation to the intraocular pressure response after topically applied latanoprost in glaucoma patients [97]. Additionally, a MDR1 variant (3435c>T, rs1045642) was recently associated to the enhanced intraocular pressure response of latanoprost [98]. Notably, several other studied variants of MRP4, MDR1 and OATP2A1 showed no impact on intraocular pressure response after latanoprost or other prostaglandin analog treatment [97,99].…”

Section: Accepted Manuscript 6 Pharmacogenetics In Omentioning

confidence: 99%

Expression, activity and pharmacokinetic impact of ocular transporters

Vellonen

Hellinen

Mannermaa

et al. 2018

Advanced Drug Delivery Reviews

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The eye is protected by several tissues that limit the permeability and entry of potentially harmful substances, but also hamper the delivery of drugs in the treatment of ocular diseases. Active transport across the ocular barriers may affect drug distribution, but the impact of drug transporters on ocular drug delivery is not well known. We have collected and critically reviewed the literature for ocular expression and activity of known drug transporters. The review concentrates on drug transporters that have been functionally characterized in ocular tissues or primary cells and on transporters for which there is available expression data at the protein level. Species differences are highlighted, since these may explain observed inconsistencies in the influence of specific transporters on drug disposition. There is variable evidence about the pharmacokinetic role of transporters in ocular tissues. The strongest evidence for the role of active transport is available for the blood-retinal barrier. We explored the role of active transport in the cornea and blood retinal barrier with pharmacokinetic simulations. The simulations show that the active transport is important only in the case of specific parameter combinations.

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Section: Accepted Manuscript 6 Pharmacogenetics In Omentioning

confidence: 99%

Expression, activity and pharmacokinetic impact of ocular transporters

Vellonen

Hellinen

Mannermaa

et al. 2018

Advanced Drug Delivery Reviews

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“…The most frequently studied polymorphisms in the ABCB1 gene are C1236T (rs1128503), G2677T/A (rs2032582) and C3435T (rs1045642). Genetic variants associated with a change in the amount or activity of transport proteins lead to the loss of the physiological role of these proteins and altered various drugs transporter's functions 8,9 . These three most common ABCB1 SNPs in the Caucasian population have been found to be in linkage disequilibrium.…”

mentioning

confidence: 99%

The impact of ABCB1 gene polymorphism and its expression on non-small-cell lung cancer development, progression and therapy – preliminary report

Zawadzka

Jeleń

Pietrzak

et al. 2020

Sci Rep

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the ABCB1 gene belongs to Atp binding cassette (ABc) transporter genes that has been previously implicated in cancer progression and drug response. this study aimed to evaluate the association between the SNP 3435 and the expression of the ABCB1 gene in lung cancer patients in the polish population in comparison to clinicopathological parameters and treatment. 150 RNA and 47 DNA samples were isolated from 49 lung cancer cases including both tissue samples and blood taken from the same patients at three time points: diagnosis, 100 days and one year after the surgical intervention. Qualitative and real-time pcR analysis of expression were done, also genotyping by PCR-RFLP. Mutant homozygous TT and allele T are present statistically significantly more frequently in the group of patients with lung cancer. There is no difference with expression level in lung cancer tissue and blood sample taken from the same patients before surgical treatment. on the basis of blood samples analysis it was observed that the expression level of ABCB1 mRnA was growing in time. Higher levels were marked after 100 days and one year after the surgical intervention. The complementary pharmacological treatment induced higher expression levels of ABCB1. the presented data suggest an important role of ABCB1 in lung cancer, the increasing level of ABCB1 mRnA which can be connected with induction of multidrug resistance mechanism is also significant, that observation must be confirmed in further analysis.

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“…Similar results were obtained by Liu et al in the study of the role of SNP in ABCB1 gene in susceptibility to primary open-angle glaucoma. In this study there were no significant differences in ABCB1 T-129C frequencies in investigated and control groups [31]. Studies on the role of T-129C polymorphism in the ABCB1 gene were also conducted in ovarian cancer.…”

Section: Discussionmentioning

confidence: 51%

Association of ABCB1 T-129C polymorphism and multiple myeloma risk in Polish population

Niebudek¹,

Balcerczak²,

Mirowski³

et al. 2018

pjp

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The possible interaction between gene polymorphism and cancer risk development is a very interesting issue. The genetic variants of the ATP-binding cassette superfamily B member 1 (ABCB1) are known to be involved in developing cancer risk and individual differences in chemotherapeutic response. Polymorphisms may affect the reduction of the activity and/or expression of important protective cellular proteins. The increased exposure to toxic compounds, including carcinogens is associated with an increased risk of developing cancers. The present study was aimed to evaluate the possible effect of ABCB1 T-129C single nucleotide polymorphism in risk of cancer development in Polish patients diagnosed with multiple myeloma. 91 multiple myeloma patients and 94 healthy controls were enrolled in this case-control study. The ABCB1 T-129C genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism method (PCR-RFLP). The distribution of particular genotypes between multiple myeloma patients and controls group was not significantly different for T-129C SNP (p = 0.4297). The studied polymorphism does not seem to affect the increased risk of multiple myeloma development.

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ABCB1 variants confer susceptibility to primary open-angle glaucoma and predict individual differences to latanoprost treatment

Cited by 14 publications

References 37 publications

Expression, activity and pharmacokinetic impact of ocular transporters

Expression, activity and pharmacokinetic impact of ocular transporters

The impact of ABCB1 gene polymorphism and its expression on non-small-cell lung cancer development, progression and therapy – preliminary report

Association of ABCB1 T-129C polymorphism and multiple myeloma risk in Polish population

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