2012
DOI: 10.1016/j.ejca.2012.05.027
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ABCB5 expression and cancer stem cell hypothesis in oral squamous cell carcinoma

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Cited by 80 publications
(52 citation statements)
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“…CK-17 is thought to be stained in OIN/CIS and suggest malignant transformation [26]. As cancer stem cells exist in the basal layer and outer layer of cancer cell nests [27], SPARCpositive cells do not reflect stem cells. D2-40, one of the cancer stem cell markers [28], usually localizes in the basal layer and outer layer of cancer cell nests.…”
Section: Discussionmentioning
confidence: 99%
“…CK-17 is thought to be stained in OIN/CIS and suggest malignant transformation [26]. As cancer stem cells exist in the basal layer and outer layer of cancer cell nests [27], SPARCpositive cells do not reflect stem cells. D2-40, one of the cancer stem cell markers [28], usually localizes in the basal layer and outer layer of cancer cell nests.…”
Section: Discussionmentioning
confidence: 99%
“…As to the biology of CSCs, this aspect could become highly significant, as there is evidence that a number of cytostatics trigger CSC phenotypes as recently reported by some groups. Abductively, if anticancer agents induce CSC phenotypes and cellular heterogeneity, it is mandatory to analyze the biological role of these recurrent cell populations in tumor genesis and differentiation (Donnenberg and Donnenberg, 2005;Díaz-Carballo et al, 2010Kitambi, 2011;Grimm et al, 2012).…”
Section: Discussionmentioning
confidence: 99%
“…Although enhanced GEP and ABCB5 expressions have been demonstrated in a number of human CSCs, whether other cell types would express GEP and ABCB5 remain to be elucidated. Nonetheless, the presence of CSCs has been demonstrated in a number of solid tumors, including brain, colon, breast, prostate, pancreatic, and liver cancers (24)(25)(26)(27)(28)(29)(30)(31)(32). The enrichment of CSCs after chemotherapy has recently been revealed in breast, lung, and liver cancers (33)(34)(35).…”
Section: Discussionmentioning
confidence: 99%
“…3 and 4) and also in chemoresistant cells (21). ABCB5 expressions have been demonstrated to associate with CSCs properties in melanoma (26) and oral squamous cell carcinoma (27). However, reimplantation of the chemotreated residual cells to test the tumor-forming abilities should be attempted if there have enough cells for the experiment after chemotherapy.…”
Section: Discussionmentioning
confidence: 99%