Abdelazim equation

Abstract

Measurement of 24-h urine protein (UP) is the standard method for detection of proteinuria in preeclampsia (PE). A 24-h urine sampling is time-consuming, inconvenient, and delays the diagnosis of PE. A 29-year-old woman, previous cesarean section (CS), pregnant 37 weeks' +2 days , mild PE, and another 31-year-old woman, primipara, pregnant 34 weeks' +4 days , severe PE, were admitted for control of blood pressure and termination of pregnancy. Studied women were subjected to fetal well-being assessment, routine antenatal, and laboratory investigations to exclude chronic renal diseases, and for 24-h urine sampling. A spot mid-stream urine sample was obtained shortly before the 24-h urine sampling to measure the protein/creatinine (P/C) ratio. The first studied woman had normal serum creatinine and blood urea, 688 mg protein/24-h urine, 86 mg/dL spot UP, 178 mg/dL spot urine creatinine, and 0.48 P/C ratio. The second studied woman had also normal serum creatinine and blood urea, 1199 mg protein/24-h urine, 147 mg/dL spot UP, 133 mg/dL spot urine creatinine, and 1.11 spot P/C ratio. The spot urine sample was suggested by the National Kidney Foundation to detect and monitor proteinuria in adults. Moreover, the 24-h UP can be calculated from the following equation: 24-h UP in g = P/C ratio × 0.81 + 0.3 (Abdelazim equation) without 24-h urine sampling. This report suggests the use of Abdelazim equation (24-h UP in g = P/C ratio × 0.81 + 0.3) for detection of 24-h UP from spot urine sample in PE without 24-h urine sampling.

The relation between serum uric acid and severity of preeclampsia in pregnant women: a cross-sectional study

“…The protein/creatinine ratio of 0.45 corresponds to 300 mg proteins/24-hr urine, while the P/C ratio of 0.9 corresponds to 1000 mg proteins/24-hr urine [ 13 , 14 ].…”

“…The biuret colorimetric (Cobas Integra Analyzer, Switzerland) method was used to measure the urine proteins [ 16 ]. The modified Jaffe (Hitachi Autoanalyzer, Japan) test was used to measure the urine creatinine [ 13 , 14 ]. The serum uric acid was measured by the enzymatic method.…”