Abdomen: Diffusion-weighted MR Imaging with Pulse-triggered Single-Shot Sequences

Mürtz, Petra; Flacke, Sebastian; Träber, Frank; Brink, J.S. van den; Gieseke, Jürgen; Schild, Hans H.

doi:10.1148/radiol.2241011117

Cited by 206 publications

(193 citation statements)

References 17 publications

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“…Breathhold SS EPI sequences are fast, however, suffer from low SNR especially at higher b-values. Techniques such as parallel imaging (25,26) and pulse triggering (27) have been proposed to improve diffusion image quality and precision of ADC measurement. Respiratory triggering is another method that can be proposed to improve image quality of DWI.…”

Section: Discussionmentioning

confidence: 99%

“…SS EPI sequences are very fast, however, suffer from limited image quality, mostly related to limited signal to noise ratio (SNR) especially at higher b-values, and limited spatial resolution, which constitute an obstacle for its widespread use in clinical practice. Techniques such as parallel imaging (25,26) and pulse triggering (27) have been proposed to improve SS EPI image quality and precision of ADC measurement.…”

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confidence: 99%

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Diffusion‐weighted imaging of the liver: Comparison of navigator triggered and breathhold acquisitions

Taouli

Sandberg

Stemmer

et al. 2009

Magnetic Resonance Imaging

150

122

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Purpose: To compare a free breathing navigator triggered single shot echoplanar imaging (SS EPI) diffusion-weighted imaging (DWI) sequence with prospective acquisition correction (PACE) with a breathhold (BH) DWI sequence for liver imaging. Materials and Methods:Thirty-four patients were evaluated with PACE-DWI and BH DWI of the liver using bvalues of 0, 50, and 500 s/mm 2 . There were 29 focal liver lesions in 18 patients. Qualitative evaluation was performed on a 3-point scale (1-3) by two independent observers (maximum score 9). Quantitative evaluation included estimated SNR (signal to noise ratio), lesion-to-liver contrast ratio, liver and lesion apparent diffusion coefficients (ADCs), and coefficient of variation (CV) of ADC in liver parenchyma and focal liver lesions (estimate of noise contamination in ADC).Results: PACE-DWI showed significantly better image quality, higher SNR and lesion-to-liver contrast ratio when compared with BH DWI. ADCs of liver and focal lesions with both sequences were significantly correlated (r ϭ 0.838 for liver parenchyma, and 0.904 for lesions, P Ͻ 0.0001), but lower with the BH sequence (P Ͻ 0.02). There was higher noise contamination in ADC measurement obtained with BH DWI (with a significantly higher SD and CV of ADC). Conclusion:The use of a navigator echo to trigger SS EPI DWI improves image quality and liver to lesion contrast, and enables a more precise ADC quantification compared with BH DWI acquisition. THERE IS A GROWING interest in using liver diffusionweighted imaging (DWI) for lesion detection and characterization, prediction of treatment response and assessment of chronic liver disease, by means of apparent diffusion coefficient (ADC) measurement (1-20). The interest in DWI is motivated by the recently described risk of nephrogenic systemic fibrosis (21-24), which makes DWI an attractive alternate method to Gadolinium-enhanced sequences. Most prior studies have used breathhold (BH) single shot echoplanar imaging (SS EPI) to acquire diffusion-weighted images, using various sets of b-values. SS EPI sequences are very fast, however, suffer from limited image quality, mostly related to limited signal to noise ratio (SNR) especially at higher b-values, and limited spatial resolution, which constitute an obstacle for its widespread use in clinical practice. Techniques such as parallel imaging (25,26) and pulse triggering (27) have been proposed to improve SS EPI image quality and precision of ADC measurement.There are several recent reports on the use of respiratory triggered acquisitions for liver DWI (15,16,[28][29][30][31]. However, only two studies have specifically compared different diffusion acquisition schemes for liver imaging (28,30). The first study (28) included a population of patients with liver lesions, and compared image quality and ADC of free breathing versus BH DWI. The second study included healthy volunteers, and compared BH, free breathing and respiratory triggered DWI (without navigator echoes) (30). There are, however, no reports on the use of a...

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Diffusion‐weighted imaging of the liver: Comparison of navigator triggered and breathhold acquisitions

Taouli

Sandberg

Stemmer

et al. 2009

Magnetic Resonance Imaging

150

122

View full text Add to dashboard Cite

show abstract

“…However, signal loss in DWI and artificially elevated ADCs have been reported to occur in the left liver lobe [5][6][7]. A possible explanation for this phenomenon is cardiac motion.…”

Section: Introductionmentioning

confidence: 99%

“…Consequently, regional deformation and/or acceleration may occur, which affects intravoxel incoherent motion imaging and measurements (i.e. DWI and ADC measurements, respectively) [5][6][7]. Thus, if no cardiac triggering is employed, both detectability of lesions, and reliability and reproducibility of ADC measurements in the left lobe of the liver may be impaired [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

“…DWI and ADC measurements, respectively) [5][6][7]. Thus, if no cardiac triggering is employed, both detectability of lesions, and reliability and reproducibility of ADC measurements in the left lobe of the liver may be impaired [5][6][7]. On the other hand, it has recently been reported that signal loss and artificially elevated ADCs may be encountered in the right liver lobe as well [8].…”

Section: Introductionmentioning

confidence: 99%

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Influence of cardiac motion on diffusion-weighted magnetic resonance imaging of the liver

Kwee

Takahara

Niwa

et al. 2009

Magn Reson Mater Phy

103

101

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Purpose To assess cardiac motion-induced signal loss in diffusion-weighted magnetic resonance imaging (DWI) of the liver using dynamic DWI. Materials and methods Three volunteers underwent dynamic coronal DWI of the liver under breathholding, in the diastolic (DWI diast ) or systolic (DWI syst ) cardiac phase, and with motion probing gradients (MPGs) in phase encoding (P, left-right), frequency encoding (M, superior-inferior), or slice select (S, anterior-posterior) direction. Liver-to-background contrasts (LBCs) of DWI syst were compared to those of DWI diast , for both the left and right liver lobes, using nonparametric tests. Signal decrease ratios (SDRs) were calculated as (1 (median 3.35) were significantly lower (P < 0.0001) than those of DWI diast (median 4.84). In the right liver lobe, LBCs of DWI syst (median 4.17) were also significantly lower (P < 0.0001) than those of DWI diast (median 5.35). SDRs of the left and right liver lobes were 25.5% and 17.3%, respectively. In DWI syst , the significantly lowest (P < 0.05) LBCs were observed in the M direction (left liver lobe) and P direction (right liver lobe) of MPGs. Conclusion Signal intensity of both liver lobes are affected by cardiac motion in DWI. In the left liver lobe, signal loss especially occurs in the superior-inferior direction of MPGs, whereas in the right lobe, signal loss especially occurs in the left-right direction of MPGs.

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Amino‐terminal fragment of the prohormone brain‐type natriuretic peptide in rheumatoid arthritis

Solus¹,

Chung²,

Oeser³

et al. 2008

Arthritis & Rheumatism

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Objective. Increased concentrations of N-terminal pro-brain natriuretic peptide (NT-proBNP) are associated with cardiovascular morbidity and mortality, but little is known about their relationship to chronic inflammation. Patients with rheumatoid arthritis (RA) have chronic inflammation, increased arterial stiffness, and accelerated coronary atherosclerosis. This study was undertaken to test the hypothesis that NT-proBNP concentrations are elevated in patients with RA and are associated with coronary artery calcification and markers of inflammation.Methods. In 159 patients with RA (90 with early RA and 69 with longstanding RA) without heart failure and 88 control subjects, serum concentrations of NTproBNP, interleukin-6 (IL-6), and tumor necrosis factor ␣ (TNF␣) were measured and coronary calcification was assessed. Associations between NT-proBNP levels and the other parameters were investigated.Results Conclusion. NT-proBNP concentrations are increased in patients with RA without clinical heart failure and may indicate subclinical cardiovascular disease and a chronic inflammatory state.

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Abdomen: Diffusion-weighted MR Imaging with Pulse-triggered Single-Shot Sequences

Cited by 206 publications

References 17 publications

Diffusion‐weighted imaging of the liver: Comparison of navigator triggered and breathhold acquisitions

Diffusion‐weighted imaging of the liver: Comparison of navigator triggered and breathhold acquisitions

Influence of cardiac motion on diffusion-weighted magnetic resonance imaging of the liver

Amino‐terminal fragment of the prohormone brain‐type natriuretic peptide in rheumatoid arthritis

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