Abdominal aneurysm in South African Negroes due to intimomedial mucoid degeneration

Decker, G; Samson, Ian D.; Schmaman, A

doi:10.1002/bjs.1800640718

Cited by 14 publications

(16 citation statements)

References 11 publications

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“…The mean age in the present study was 36.8 years, whereas the Decker series had a mean age of 51.1 years .' 1 Intimomedial mucoid degeneration is not unique to South African blacks. In 1973 Steiner et al described an abdominal aneurysm in a twenty-two-year old Ugandan woman.5 Histology revealed increased ground substance of the media with a moderate loss of elastic fibers in the aneurysmal wall.…”

Section: Discussionmentioning

confidence: 98%

Extraaortic Intimomedial Mucoid Degeneration: A Clinicopathological Study

Cooper

1993

Angiology

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Six black patients with extraaortic intimomedial mucoid degeneration of the major arterial branches of the aorta are reported. Five patients presented with aneurysmal dilatation of the arterial wall as a result of the intimomedial mucoid degeneration, and the sixth patient had superimposed occlusive thrombosis. The ages ranged from twenty to fifty years. Five patients were female. Two were hypertensive. All patients in this study underwent reconstructive vascular surgery. The clinical and histopathologic findings are discussed.

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Section: Discussionmentioning

confidence: 98%

Extraaortic Intimomedial Mucoid Degeneration: A Clinicopathological Study

Cooper

1993

Angiology

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“…Various studies have shown that aneurysms in IMMD affect a younger population group than what is found in conventional non-specific degenerative aneurysms. 1 , 4 , 6 As in this case, patients with IMMD have a high prevalence of hypertension, which aggravates the elastic tissue breakdown, resulting in aneurysm formation. 1 , 4 , 6 , 9 , 11 …”

Section: Discussionmentioning

confidence: 83%

“… 2 , 11 A striking feature on histological examination is the absence of any inflammatory reaction. 1 The features are distinct from cystic medial necrosis, in which only the media is affected by the mucin accumulation. 1 , 4 Cystic medial necrosis is also typically confined to the aorta, whereas IMMD has been found to involve extraaortic vessels.…”

Section: Discussionmentioning

confidence: 99%

“…9 The term ‘intimomedial mucoid degeneration’ was first used in 1977 by Decker et al from Johannesburg in their case series of nine patients with aortic aneurysms. 1 Due to the lack of understanding of its aetiology, the condition was defined in pathological terms describing its histological features. 1 , 10 , 11 …”

Section: Discussionmentioning

confidence: 99%

“…Intimomedial mucoid degeneration (IMMD) is a rare vascular disorder characterised by the deposition of mucin in the intima and media, which leads to elastic tissue degeneration and aneurysm formation of the arterial wall. 1 - 4 Although the condition was initially thought to involve only the aorta, subsequent publications have reported IMMD to affect the major branches of the aorta, as well as smaller vessels such as the coronary and brachial arteries. 1 , 5 , 6 - 8 The aneurysms in IMMD usually have a saccular or fusiform morphology and cause symptoms related to the location of the aneurysm.…”

Section: Introductionmentioning

confidence: 99%

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Intimomedial mucoid degeneration causing aortic and renal artery aneurysms in a young adult

Viljoen

Szymanski

Osman

et al. 2016

CVJA

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Intimomedial mucoid degeneration (IMMD) is characterised by aneurysm formation following mucin deposition in the intima and media, with elastic tissue degeneration of the arterial wall. We present a case of a young adult who developed a diffusely aneurysmal aorta and its major branches, which was histopathologically confirmed as intimomedial mucoid degeneration, and a review of the literature. This case report attempts to raise the awareness of the reader to this rare cause of aortic aneurysm and to the bleeding diathesis associated with IMMD that may complicate surgery.

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Abdominal aneurysms in a black population: Clinicopathological study

Costa

Robbs

1986

Journal of British Surgery

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With exclusion of vascular trauma 2182 patients (1302 black and 880 white) have been treated in our Vascular Service over a period of 3 years. Sixty black patients (4.6 per cent) and 260 white patients (29.5 per cent) presented with aneurysms of the aorta and its abdominal branches. The aneurysms in the black group were distributed as follows: 50 aortic (9 suprarenal, 41 infrarenal), 6 common iliac artery, 2 superior mesenteric and 2 renal artery aneurysms. None of the 260 aneurysms seen in white patients involved arteries other than the aorta (16 suprarenal, 244 infrarenal). In the black group there was an almost equal distribution among sexes, whereas in the white group there was a male to female ratio of 2:1. The mean age was 49.4 years among the black patients, and 67.1 years among the white patients. Surgery was performed on 47 black patients and 245 white patients. Among the black patients 16 aneurysms were atherosclerotic (34 per cent), 22 were of non-atherosclerotic origin (47 per cent) and 9 were of uncertain nature (19 per cent). Of the 22 non-atherosclerotic aneurysms 14 were due to non-specific aorto-arteritis, 4 were due to tuberculous arteritis, 2 were due to intimomedial mucoid degeneration, 1 was due to syphilitic aortitis and 1 was a mycotic aneurysm. In the white group 243 aneurysms were atherosclerotic and 2 had changes of intimomedial mucoid degeneration. All aneurysms were treated along standard surgical lines, antituberculous treatment was initiated when appropriate. It was concluded that abdominal aneurysm is an uncommon disease in black patients. When it occurs a more heterogeneous pathology can be expected with an unusually high prevalence of aorto-arteritis compared with the white population.

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Abdominal aneurysm in South African Negroes due to intimomedial mucoid degeneration

Cited by 14 publications

References 11 publications

Extraaortic Intimomedial Mucoid Degeneration: A Clinicopathological Study

Extraaortic Intimomedial Mucoid Degeneration: A Clinicopathological Study

Intimomedial mucoid degeneration causing aortic and renal artery aneurysms in a young adult

Abdominal aneurysms in a black population: Clinicopathological study

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