Abdominal obesity vs general obesity for identifying arterial stiffness, subclinical atherosclerosis and wave reflection in healthy, diabetics and hypertensive

Recio-Rodríguez, José I; Gómez‐Marcos, Manuel A.; Patino-Alonso, María C.; Agudo‐Conde, Cristina; Rodríguez‐Sánchez, Emiliano; García‐Ortiz, Luis

doi:10.1186/1471-2261-12-3

Cited by 123 publications

(96 citation statements)

References 38 publications

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“…Accumulation of fat tissue, especially in the abdominal region, predisposes to a series of risk factors through a highly frequent association with outcomes that favor the occurrence of cardiometabolic disorders 41,42 .…”

Section: Discussionmentioning

confidence: 99%

Razão cintura-estatura como marcador antropométrico de excesso de peso em idosos brasileiros

et al. 2017

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O objetivo deste estudo foi identificar o ponto de corte da razão cintura-estatura (RCE) com melhor sensibilidade, especificidade e acurácia para a população idosa brasileira utilizando o índice de massa corporal (IMC) como referência antropométrica. A amostra representativa da população brasileira foi composta por 5.428 indivíduos idosos, participantes de um inquérito epidemiológico. As variáveis avaliadas foram peso, altura e circunferência da cintura (CC). A RCE foi avaliada tendo como padrão-ouro o IMC utilizando duas propostas de classificação do estado nutricional para a população idosa. O ponto de corte ideal da RCE mostrando simultaneamente a mais alta sensibilidade e especificidade foi determinado utilizando a curva ROC (receiver operating characteristic). Sensibilidade entre 94,9% e 98,4%, especificidade variando de 43% a 55,4% e valores da área sob a curva ROC entre 0,878 e 0,883 foram identificados para o ponto de corte de 0,55. Recomenda-se a utilização da RCE na prática clínica por sua simplicidade e pelo bom poder de detecção de excesso de peso em idosos.

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Section: Discussionmentioning

confidence: 99%

Razão cintura-estatura como marcador antropométrico de excesso de peso em idosos brasileiros

et al. 2017

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“…In adults, a positive relationship between obesity and PWV has been described in cross-sectional studies, 22,23 and a reduction in PWV was observed after losing weight, 24 although these studies had not considered the impact of BP values at the same time. Controversial results exist in the childhood population 14,25,26 that may be partially explained by differences in patient populations (age, sex, and small sample size) and heterogeneity of the techniques used.…”

Section: Discussionmentioning

confidence: 99%

Blood Pressure and Obesity Exert Independent Influences on Pulse Wave Velocity in Youth

et al. 2012

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Abstract-The objective was to analyze pulse wave velocity (PWV) in normotensive, high-normal, and hypertensive youths by using aortic-derived parameters from peripheral recordings. The impact of obesity on vascular phenotypes was also analyzed. A total of 501 whites from 8 to 18 years of age were included. The subjects were divided according to BP criteria: 424 (85%) were normotensive, 56 (11%) high-normal, and 21 (4%) hypertensive. Obesity was present in 284 (56%) and overweight in 138 (28%). Pulse wave analysis using a SphygmoCor device was performed to determine central blood pressure (BP), augmentation index, and measurement of PWV. Among the BP groups, differences appeared in age, sex, and height but not in body mass index. Significant differences in peripheral and central systolic and diastolic BPs and pulse pressures were observed within groups. A graded increase in PWV was present across the BP strata without differences in augmentation index. Using a multiple regression analysis, age, BP groups, and obesity status were independently associated with PWV. Older and hypertensive subjects had the highest PWV, whereas, from normal weight status to obesity, PWV decreased. Likewise, PWV was positively related to peripheral or central systolic BP and negatively related to body mass index z score. For 1 SD of peripheral systolic BP, PWV increased 0.329 m/s, and for 1 SD of body mass index z score PWV decreased 0.129 m/s. In conclusion, PWV is increased in hypertensive and even in high-normal children and adolescents. Furthermore, obesity, the factor most frequently related to essential hypertension in adolescents, blunted the expected increment in PWV of hypertensive and high-normal subjects. (Hypertension. 2012;60:550-555.)Key Words: hypertension Ⅲ obesity Ⅲ children Ⅲ adolescents Ⅲ augmentation index Ⅲ pulse wave velocity C ardiovascular damage occurring in adults finds its roots in risk factors operating early in life. Among the factors influencing cardiovascular risk, blood pressure (BP) values represent an important measurable marker of the level of potential cardiovascular risk in children and adolescents. The need to identify cardiovascular risk factors, including high BP, in youth, is acknowledged more and more frequently. Consequently, measurement of BP has become a routine part of pediatric care, and asymptomatic hypertension is now detected in pediatric care practice.BP phenotype is determined not only by conventional risk factors but also by weight gain in childhood. The adverse effects of excessive weight gain on BP and the association of weight gain with higher incidence of BP elevation represent major issues in health care.1-5 Elevation of systolic and/or diastolic BP indicates high BP in the child. In addition, children and adolescents with mild BP elevation, in the high-normal range, are much more common than was thought in the past, ranging from 3.4% to 15.7%. 6,7 Rather than having a goal of classifying children as high-normal, we should be identifying those who may be at risk for the developm...

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“…Yu et al [33] found that abdominal obesity by itself is an independent marker of subclinical atherosclerosis in women. In other studies, abdominal obesity was also associated with arterial stiffness [34] and an increase in carotid intima media thickness [34,35]. Konishi et al [36] showed that the visceral fat area is associated with carotid artery plaque formation in type 2 diabetes.…”

Section: Discussionmentioning

confidence: 99%

Body Fat Distribution as a Risk Factor for Cerebrovascular Disease: An MRI-Based Body Fat Quantification Study

et al. 2013

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Background: While adiposity is a well-established risk factor for cardiovascular disease, the association between adiposity and cerebrovascular disease is not entirely understood. For example, common methods to quantify body fat volume such as body mass index, waist circumference and waist-to-hip ratio are not suitable to identify the complex distribution patterns of body fat and its relation to cerebrovascular pathology. In view of a better understanding of the association between fat distribution and cerebrovascular disorders, the aim of the study was to perform measurements of body fat distribution patterns and body fat volumes in correlation to arteriosclerosis of the brain-feeding arteries and white matter lesion load (WMLL). Methods: In this study we performed a magnetic resonance imaging (MRI)-based volumetric differential analysis of subcutaneous and visceral body fat distribution in 25 patients with MRI-proven hyperacute ischemic stroke. For the measurement of adipose tissue volume and tissue distribution automatic labeling analysis software was used. A correlation analysis of MRI volumetric measurements of subcutaneous and visceral body fat, atherosclerotic plaque load of the brain-feeding arteries measured by computed tomography angiography, and WMLL measured by MRI volumetry of the whole brain was performed. Results: The normalized total abdominal adipose tissue and the normalized subcutaneous abdominal adipose tissue showed no significant correlation with either WMLL or total plaque volume. In contrast, the normalized visceral adipose tissue showed a significant correlation with WMLL volume. Visceral adipose tissue as a percentage of total adipose tissue showed a significant correlation with WMLL. In particular, the percentage of visceral adipose tissue rather than total body fat volume strongly correlated with atherosclerosis and ischemic cerebral lesions. Furthermore, the volume of both soft and calcified plaques correlated significantly with WMLL. Conclusions: Our results contribute to existing studies about the association of different patterns of fat distribution with atherosclerosis of the brain-feeding arteries, in particular highlighting the importance of visceral adiposity as a risk factor for cerebrovascular disease. The percentage of visceral adipose tissue in total adipose tissue has the potential of a sensitive parameter and might become a relevant new epidemiological marker, showing highly significant correlations with well-established markers of cerebrovascular disease. In conclusion, the percentage of visceral adipose tissue by itself has to be regarded as a risk factor for both small vessel cerebrovascular disease and cerebral atherosclerosis of the large-to-medium-sized arteries.

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Abdominal obesity vs general obesity for identifying arterial stiffness, subclinical atherosclerosis and wave reflection in healthy, diabetics and hypertensive

Cited by 123 publications

References 38 publications

Razão cintura-estatura como marcador antropométrico de excesso de peso em idosos brasileiros

Razão cintura-estatura como marcador antropométrico de excesso de peso em idosos brasileiros

Blood Pressure and Obesity Exert Independent Influences on Pulse Wave Velocity in Youth

Body Fat Distribution as a Risk Factor for Cerebrovascular Disease: An MRI-Based Body Fat Quantification Study

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