Abdominal wall mucormycosis after heart transplantation

Kerbaul, François; Guidon, C.; Collart, Frédéric; Lépidi, Hubert; Cayatte, Bruno; Bonnet, Marc; Bellezza, M.; Métras, D

doi:10.1053/j.jvca.2004.08.033

Cited by 10 publications

(17 citation statements)

References 4 publications

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“…1,4 In the present patient, the diagnosis of fungal infection was considered late and only after prolonged antibiotic therapy with no response. Early diagnosis and treatment of mucormycosis is important for preventing morbidity and mortality.…”

Section: Discussionmentioning

confidence: 86%

“…2 The best diagnostic methods include tissue biopsy for direct smear and fungal culture. 1 Histopathologic examination may show ribbonlike, wide, thick hyphae with right angle branches and no septation. Other histopathologic findings include vascular invasion, thrombosis, infarction, and hemorrhage.…”

Section: Discussionmentioning

confidence: 99%

“…Other histopathologic findings include vascular invasion, thrombosis, infarction, and hemorrhage. 1,2,4,5 Treatment of mucormycosis includes minimizing immunosuppressive drugs, correcting metabolic disorders, performing radical surgical debridement, and giving systemic antifungal drugs. Amphotericin B is the best antifungal drug, but some azoles such as posaconazole may have efficacy against Mucorales.…”

Section: Discussionmentioning

confidence: 99%

“…[1][2][3][4][5] These grow rapidly and produce airborne spores. 6 These spores are ubiquitous and commonly grow in the soil, animal waste, vegetables, fruits, and breads.…”

Section: Introductionmentioning

confidence: 99%

“…1,5,[7][8][9] The risk factors for developing mucormycosis include poorly controlled diabetes mellitus, immunosuppressive drugs, chemotherapy, hematologic malignancies (eg, leukemia and lymphoma), neutropenia, contaminated traumatic ulcers, burn wounds, malnutrition, stem cell and solid-organ transplant recipients, kidney and liver failure, corticosteroid therapy, broad-spectrum antibiotic therapy, deferoxamine therapy, intravenous drug use, and low birth weight. 1,4,5,10,11 Patients who have severe immunodeficiency and who are admitted to the hospital are at greatest risk for developing this infection. 5 Mucormycosis usually is transmitted in humans by inhalation or inoculation of spores in the skin or mucous membranes.…”

Section: Introductionmentioning

confidence: 99%

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Davuodi

Manshadi²,

Salehi³

et al. 2015

Exp Clin Transplant

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Mucormycosis is an uncommon opportunistic infection that is caused by Mucorales from the Zygomycetes class. Patients with severe immunodeficiency admitted to the hospital are at greatest risk for developing this infection. Mucormycosis usually is transmitted in humans by inhalation or inoculation of spores in the skin or mucous membranes.A 66-year-old man developed a surgical wound infection at 1 week after kidney transplant that did not improve despite broad-spectrum antibiotics and debridement. He was transferred to our hospital 45 days after transplant and had fever and a large purulent wound that was surrounded by a black necrotizing margin. Immunosuppressive drugs were discontinued and the dosage of prednisolone was decreased. Massive debridement was performed but was incomplete because he had full-thickness abdominal wall necrosis. Histopathology showed broad fungal hyphae without septation, consistent with the diagnosis of mucormycosis. Despite antifungal therapy with amphotericin B and additional debridement, the patient died of septic shock at 52 days after kidney transplant.Cutaneous fungal infections should be considered in the differential diagnosis of any nonhealing infected wound that does not respond to broadspectrum antibiotics, especially in patients with predisposing risk factors such as transplant.

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Section: Discussionmentioning

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…[1][2][3][4][5] These grow rapidly and produce airborne spores. 6 These spores are ubiquitous and commonly grow in the soil, animal waste, vegetables, fruits, and breads.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Untitled

Davuodi

Manshadi²,

Salehi³

et al. 2015

Exp Clin Transplant

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Post-operative Abdominal Wall Mucormycosis—a Case Series

et al. 2012

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Mucormycosis is caused by saprophtytic fungi which cause acute invasive zygomycosis. It clinically presents with necrosis, and on histopathology, acute and chronic infiltrates are seen. It rarely infects a healthy host, but is devastating in an immunocompromised host. We studied five cases with post-operative abdominal wall mucormycosis, three females and two males. Three patients were post-operative while the other two had mucormycosis following trauma and infection was found in sutured wound. All were initially diagnosed as cases of necrotizing fasciitis. Two patients eventually survived after intensive medical therapy and extensive debridements.

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Principes thérapeutiques des dermohypodermites bactériennes nécrosantes et des fasciites nécrosantes

Giuly

Velly

2006

Annales Françaises d'Anesthésie et de Réanimation

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Abdominal wall mucormycosis after heart transplantation

Cited by 10 publications

References 4 publications

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Untitled

Post-operative Abdominal Wall Mucormycosis—a Case Series

Principes thérapeutiques des dermohypodermites bactériennes nécrosantes et des fasciites nécrosantes

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