Aberrant brain connectivity is associated with childhood maltreatment in individuals with major depressive disorder

Luo, Qianyi; Chen, Juran; Li, Yuhong; Wu, Zhiyao; Lin, Xinyi; Yao, Jiazheng; Yu, Huiwen; Wu, Huawang; Peng, Hongjun

doi:10.1007/s11682-022-00672-3

Cited by 9 publications

(12 citation statements)

References 105 publications

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“…Several studies conclude that the attention network consists of both the DAN and VAN [47]. Dysregulation of functional connectivity in the anterior portions of SMN, DAN, and DMN has been found to be associated with neuropsychiatric disorders, particularly depression [48].…”

Section: Discussionmentioning

confidence: 99%

Abnormal characteristic static and dynamic functional network connectivity in fibromyalgia attention network

Wang,

Long,

Xie

et al. 2024

Preprint

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Background and purpose: Fibromyalgia is a commonly observed pain disorder linked to cognitive impairments, encompassing challenges in attention, memory, and executive processing. It has been proposed that fibromyalgia may be caused by changes in attention network. However, the neural network mechanisms underlying the relationship between the intrinsic fluctuations of functional connectivity in the brain network and clinical symptoms remain unclear. Methods: 46 fibromyalgia patients and 36 healthy controls underwent resting-state functional MRI (rs-fMRI). We employed static functional network connectivity (sFNC) and dynamic functional network connectivity (dFNC) to investigate the potential relationship between alterations in sensory integration and attention networks in fibromyalgia and clinical features. Results: Patients with fibromyalgia had reduced functional connectivity within the visual network (VIN), the auditory network (AUN), the default mode network (DMN), and the sensorimotor network (SMN). The decrease in functional connectivity in VIN and DMN was correlated with pain levels, while an increase in functional connectivity between SMN and the posterior dorsal attention network (DAN) was associated with symptoms. dFNC further observed that patients in state 4 show increased functional coupling between the ventral attention network (VAN) and both SMN and DMN, and the number of transitions between states positively correlated with pain levels. Conclusion: dFNC offered additional insights for understanding the pathophysiological mechanisms underlying fibromyalgia. Fibromyalgia patients exhibited increased in the attention network and reduced functionality in visual and auditory networks, which might contribute to the diminished attention towards external environmental stimuli and heightened sensitivity self-perception sensations observed in fibromyalgia.

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Section: Discussionmentioning

confidence: 99%

Abnormal characteristic static and dynamic functional network connectivity in fibromyalgia attention network

Wang,

Long,

Xie

et al. 2024

Preprint

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“…Structural and functional connectivity studies have tested hypotheses regarding mechanisms responsible for these alterations in threat and reward response [77][78][79][80][81]. Studies have also revealed associations between CM and abnormalities in functional brain networks [82][83][84][85][86][87] and the structural and functional network architecture of the brain [11,15,88,89]. Multiple studies have explored the link between CM, neurobiology, and risk of psychopathology [77,[90][91][92][93][94][95], including those assessing ecophenotypic differences between maltreated and non-maltreated individuals with the same psychiatric diagnosis [16,73,[96][97][98].…”

Section: Diversity Of Studies On Maltreatment-associated Neurobiologymentioning

confidence: 99%

The neurobiological effects of childhood maltreatment on brain structure, function, and attachment

Tomoda,

Nishitani,

Takiguchi

et al. 2024

Eur Arch Psychiatry Clin Neurosci

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Childhood maltreatment is a risk factor for psychopathologies, and influences brain development at specific periods, particularly during early childhood and adolescence. This narrative review addresses phenotypic alterations in sensory systems associated with specific types of childhood maltreatment exposure, periods of vulnerability to the neurobiological effects of maltreatment, and the relationships between childhood maltreatment and brain structure, function, connectivity, and network architecture; psychopathology; and resilience. It also addresses neurobiological alterations associated with maternal communication and attachment disturbances, and uses laboratory-based measures during infancy and case–control studies to elucidate neurobiological alterations in reactive attachment disorders in children with maltreatment histories. Moreover, we review studies on the acute effects of oxytocin on reactive attachment disorder and maltreatment and methylation of oxytocin regulatory genes. Epigenetic changes may play a critical role in initiating or producing the atypical structural and functional brain alterations associated with childhood maltreatment. However, these changes could be reversed through psychological and pharmacological interventions, and by anticipating or preventing the emergence of brain alterations and subsequent psychopathological risks.

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“…In recent years, there have been a surge of studies investigating the long-term consequences of CM in depressed patients using rs-fMRI with various analytical methods. Some used seed-based interregional, or seed-based whole-brain functional connectivity analysis ( Xu et al, 2019 , Chen et al, 2022 , Luo et al, 2022 , Luo et al, 2022 , Wang et al, 2022 , Wang et al, 2022 , Goltermann et al, 2023 , Liu et al, 2024 ), others employed spatial independent component analysis (ICA; Fadel et al, 2021 , Luo et al, 2022 ). All these studies describe numerous intra-network and inter-network alterations of FC as a consequence of childhood trauma or maltreatment, but there's a great deal of variability between the reported changes.…”

Section: Introductionmentioning

confidence: 99%

Depressed patients with childhood maltreatment display altered intra- and inter-network resting state functional connectivity

Gálber,

Anett Nagy,

Orsi

et al. 2024

NeuroImage: Clinical

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Aberrant brain connectivity is associated with childhood maltreatment in individuals with major depressive disorder

Cited by 9 publications

References 105 publications

Abnormal characteristic static and dynamic functional network connectivity in fibromyalgia attention network

Abnormal characteristic static and dynamic functional network connectivity in fibromyalgia attention network

The neurobiological effects of childhood maltreatment on brain structure, function, and attachment

Depressed patients with childhood maltreatment display altered intra- and inter-network resting state functional connectivity

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