Aberrant brain oscillatory coupling from the primary motor cortex in children with autism spectrum disorders

Abstract

Highlights We measured brain oscillation and oscillatory coupling during motor control in ASD. ASD group showed reduced motor-related gamma increases compared with control group. ASD group showed enhanced pre-movement beta decreases compared with control group. ASD group showed reduced beta-gamma phase-amplitude coupling during motor control.

The Control of Movements via Motor Gamma Oscillations

“…In a series of studies with MEG and a game-like motor task An et al (2018 , 2021) investigated the neural responses associated with finger presses in normal and ASD children. These studies showed a decrease in gamma peak activity ( An et al, 2018 ) and decreased beta-gamma ipsilateral PAC activity ( An et al, 2021 ) in M1 of ASD children in comparison with healthy participants. Once again, these modulations of motor gamma oscillations may reflect an unbalance in the excitatory and inhibitory neurotransmission systems.…”

“…This notion converges with the idea of an altered neurotransmission balance in schizophrenia (Gaspar et al, Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by deficits in social communication, restricted interests, and repetitive behaviors (American Psychiatric Association, 2013). In a series of studies with MEG and a game-like motor task An et al (2018An et al ( , 2021 investigated the neural responses associated with finger presses in normal and ASD children. These studies showed a decrease in gamma peak activity (An et al, 2018) and decreased beta-gamma ipsilateral PAC activity (An et al, 2021) in M1 of ASD children in comparison with healthy participants.…”

Attenuated post-movement beta rebound reflects psychomotor alterations in major depressive disorder during a simple visuomotor task: a MEG study

“…More evidence has been provided that patients with motor abnormalities or processing speed slowing displayed attenuated PMBR. For example, Robson et al found aberrant PMBR activity in SCH [44], as well as ASD [47][48][49] and PD [40][41][42]. The evidence suggests that the reduced PMBR activity is characteristic of patients with aberrant psychomotor performance.…”

“…Previous studies found that poor motor performance in healthy older adults is related to changes in beta oscillations. Importantly, neuropsychiatric studies also revealed that decreased PMBR in PD [40][41][42], SCH [43][44][45], schizotypal personality disorder (SPD) [46] , autism spectrum disorder (ASD) [47][48][49] , re ecting impaired sensorimotor integration in psychiatric disease. In general, these ndings indicated that the aberrant PMBR impacts motor-related activity and advanced sensorimotor integration.…”

Theta-gamma phase-amplitude coupling: physiological basics, analysis methods, and perspectives of translation into clinical practice

“…Помимо болезни Альцгеймера, ТГС исследовали у пациентов с психическими заболеваниями: шизофренией [71,72], расстройствами аутистического спектра [73,74], рекуррентной депрессией [75,76], синдромом дефицита внимания с гиперактивностью [77,78]. Наибольшее количество работ по изучению ТГС включали пациентов с шизофренией, хотя ограничением является гетерогенность их методологии.…”