Aberrant Chitinase 3‐Like 1 Expression in Basal Cells Contributes to Systemic Sclerosis Fibrosis
Xiuyuan Wang,
Tianbao Ye,
Junxia Huang
et al.
Abstract:Systemic sclerosis (SSc) is an autoimmune disease characterized by extensive skin and internal organ fibrosis. However, the mechanism underlying fibrosis remains unclear, and effective treatments for halting or reversing fibrosis are lacking. In this study, single‐cell RNA sequencing is used to obtain a comprehensive overview of skin cells from patients with SSc and healthy controls. A subset of basal cells with high chitinase 3‐like 1 (Chi3L1) expression, which potentially plays an important role in fibroblas… Show more
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