2016
DOI: 10.3390/ijms17010067
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Aberrant DNA Methylation of rDNA and PRIMA1 in Borderline Personality Disorder

Abstract: Borderline personality disorder (BPD) is a serious psychic disease with a high risk for suicide. DNA methylation is a hallmark for aberrant epigenetic regulation and could be involved in the etiology of BPD. Previously, it has been reported that increased DNA methylation of neuropsychiatric genes is found in the blood of patients with BPD compared to healthy controls. Here, we analyzed DNA methylation patterns of the ribosomal RNA gene (rDNA promoter region and 5′-external transcribed spacer/5′ETS) and the pro… Show more

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Cited by 24 publications
(13 citation statements)
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“…Notably, PRIMA1 assembles acetylcholinesterases into tetramers by anchoring them at neural cell membranes [63]. Therefore, an increase in PRIMA1 methylation causes decreased enzyme function and increased cholinergic activity, which has been reported in BPD patients [64]. In 2013, Teschler et al found increased methylation in APBA2, APBA3, GATA4, KCNQ1, MCF2, NINJ2 and TAAR5 in female BPD patient blood samples compared to controls [65].…”
Section: Epigeneticsmentioning
confidence: 99%
“…Notably, PRIMA1 assembles acetylcholinesterases into tetramers by anchoring them at neural cell membranes [63]. Therefore, an increase in PRIMA1 methylation causes decreased enzyme function and increased cholinergic activity, which has been reported in BPD patients [64]. In 2013, Teschler et al found increased methylation in APBA2, APBA3, GATA4, KCNQ1, MCF2, NINJ2 and TAAR5 in female BPD patient blood samples compared to controls [65].…”
Section: Epigeneticsmentioning
confidence: 99%
“…Methylation studies of the ribosomal RNA gene ( rDNA ) promoter, 5′ external transcribed spacer gene ( 5 ′ ETS ) and of the proline rich membrane anchor 1 gene ( PRIMA1 ) promoter in PBC DNA of female subjects with BPD ( n = 24) and HC ( n = 11) revealed significantly less methylation of the rDNA promoter region in BPD compared with HC subjects, and hypomethylation of the 5 ′ ETS in BPD by trend. PRIMA1 showed a higher methylation in BPD subjects ( 28 ).…”
Section: Resultsmentioning
confidence: 93%
“…Bayes theorem is used to nd the probability of an event occurring given the probability of another event that has occurred already. It is stated mathematically as, P(C|X) = P(X|C)P(C) P(X) (13) where X and C represents the response variable and the feature vector.…”
Section: Naive Bayesmentioning
confidence: 99%
“…DNAm changes are linked with di erent types of diseases including neurological disorders, cardiovascular, and cancer [10,11,12]. Hence, studies on DNAm can also help in biomarker identi cation and disease classi cation [13,14].…”
Section: Introductionmentioning
confidence: 99%