Aberrant functioning of the putamen links delusions, antipsychotic drug dose, and compromised connectivity in first episode psychosis—Preliminary fMRI findings

Raij, Tuukka T.; Mäntylä, Teemu; Kieseppä, Tuula; Suvisaari, Jaana

doi:10.1016/j.pscychresns.2015.06.008

Cited by 17 publications

(6 citation statements)

References 46 publications

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“…The basal ganglia is a group of subcortical nuclei (putamen, pallidum, caudate nucleus, substantia nigra, and subthalamic nucleus) that involves a variety of brain functions such as motor control, learning, and execution (57). The functional and structural abnormalities of basal ganglia have been widely reported to be associated with psychotic symptoms such as delusions in schizophrenia patients (58)(59)(60), and also present in psychotic bipolar disorder patients (61). Therefore, our findings of such shared alterations in the basal ganglia may be reflective of common functional deficits in both the schizophrenia and bipolar disorder.…”

Section: Discussionmentioning

confidence: 99%

Altered Temporal Variability of Local and Large-Scale Resting-State Brain Functional Connectivity Patterns in Schizophrenia and Bipolar Disorder

et al. 2020

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Schizophrenia and bipolar disorder share some common clinical features and are both characterized by aberrant resting-state functional connectivity (FC). However, little is known about the common and specific aberrant features of the dynamic FC patterns in these two disorders. In this study, we explored the differences in dynamic FC among schizophrenia patients (n = 66), type I bipolar disorder patients (n = 53), and healthy controls (n = 66), by comparing temporal variabilities of FC patterns involved in specific brain regions and large-scale brain networks. Compared with healthy controls, both patient groups showed significantly increased regional FC variabilities in subcortical areas including the thalamus and basal ganglia, as well as increased inter-network FC variability between the thalamus and sensorimotor areas. Specifically, more widespread changes were found in the schizophrenia group, involving increased FC variabilities in sensorimotor, visual, attention, limbic and subcortical areas at both regional and network levels, as well as decreased regional FC variabilities in the default-mode areas. The observed alterations shared by schizophrenia and bipolar disorder may help to explain their overlapped clinical features; meanwhile, the schizophrenia-specific abnormalities in a wider range may support that schizophrenia is associated with more severe functional brain deficits than bipolar disorder. Together, these findings highlight the potentials of using dynamic FC as an objective biomarker for the monitoring and diagnosis of either schizophrenia or bipolar disorder.

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Section: Discussionmentioning

confidence: 99%

Altered Temporal Variability of Local and Large-Scale Resting-State Brain Functional Connectivity Patterns in Schizophrenia and Bipolar Disorder

et al. 2020

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“…CSN is linked with the mesostriatal dopaminergic system (Murray et al 2008; Palaniyappan & Liddle, 2012; Raij et al 2015) and, thus, the mesostriatal hyperdopaminergic state observed in psychosis (Howes et al 2012) may be linked to CSN functioning. Preliminary data suggests that CSN functioning may indeed contribute to the striatal dysfunction in psychosis (Raij et al 2015).…”

Section: Discussionmentioning

confidence: 99%

Cortical salience network activation precedes the development of delusion severity

et al. 2016

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“…The patients participating in the Helsinki Psychosis Study (Keinänen et al, 2015;Mäntylä et al, 2015;Raij et al, 2015;Rikandi et al, 2017) were aged 18-40, with first psychiatric treatment contact for psychosis in hospitals and outpatient clinics of the City of Helsinki and Helsinki University Hospital between December 2010 and July 2016. As a criterion for inclusion, we defined psychosis as a score of at least 4 in the items assessing unusual thought content (delusions) or hallucinations in the Brief Psychiatric Rating Scale, Expanded version 4.0, BPRS (Ventura et al, 1993), corresponding to mild but definite delusions or hallucinations.…”

Section: Participants and Study Proceduresmentioning

confidence: 99%

Childhood adversities and clinical symptomatology in first-episode psychosis

Lindgren

Mäntylä

Rikandi

et al. 2017

Psychiatry Research

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In addition to severe traumatic experiences, milder, more common childhood adversities reflecting psychosocial burden may also be common in people with psychotic disorders and have an effect on symptomatology and functioning. We explored eleven negative childhood experiences and their influence on clinical symptoms among young adults with first-episode psychosis (FEP, n = 75) and matched population controls (n = 51). Individuals with FEP reported more adversities than controls. Specifically serious conflicts within the family, bullying at school, maternal mental health problems, and one's own and parents' serious illness during childhood were experienced by the patients more often than by controls. In the FEP group, the severity of adversity was associated with increased anxiety, manic, and obsessive-compulsive symptoms, but not with the severity of positive psychotic symptoms. Adversity produced a more pronounced effect on symptoms in male patients than in female patients. To conclude, in line with earlier studies of more chronic psychosis, a majority of the participants with FEP reported exposure to childhood adversities, with the FEP group reporting more adversities than controls. High levels of mood and anxiety symptoms in patients with FEP may be related to cumulative exposure to childhood adversities. This should be taken into account in the treatment for FEP.

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Aberrant functioning of the putamen links delusions, antipsychotic drug dose, and compromised connectivity in first episode psychosis—Preliminary fMRI findings

Cited by 17 publications

References 46 publications

Altered Temporal Variability of Local and Large-Scale Resting-State Brain Functional Connectivity Patterns in Schizophrenia and Bipolar Disorder

Altered Temporal Variability of Local and Large-Scale Resting-State Brain Functional Connectivity Patterns in Schizophrenia and Bipolar Disorder

Cortical salience network activation precedes the development of delusion severity

Childhood adversities and clinical symptomatology in first-episode psychosis

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