Aberrant microRNA expression in the brains of neurodegenerative diseases: miR‐29a decreased in Alzheimer disease brains targets neurone navigator 3

Shioya, Mao; Obayashi, Shinya; Tabunoki, Hiroko; Arima, Kunimasa; Saito, Yuko; Ishida, Tsuyoshi; Satoh, Jun‐ichi

doi:10.1111/j.1365-2990.2010.01076.x

Cited by 272 publications

(184 citation statements)

References 36 publications

(44 reference statements)

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“…1a). On the other hand, the levels of miR-338-3p were not significantly different among the study groups, although a larger cohort is required to obtain a statistical power enough to make a definitive conclusion (23). Since miR-29a and miR-29b are located on the identical MIRN29B/ MIRN29A gene cluster on chromosome 7q32.3, their biological functions are presumably similar.…”

Section: Mir-29a Decreased In Ad Brains Targets Nav3mentioning

confidence: 88%

“…The microarray data were filtered through the following stringent criteria, that is, the detection of all signals above the threshold, the reference signal value exceeding 100, and the fold change expressed as the signal of ALS divided by the signal of the universal reference greater than 5. After filtration, we identified only three miRNAs, including miR-29a, miR-29b, and miR-338-3p, as a group of miRNAs whose expression is substantially upregulated in all three ALS brains (23).…”

Section: Mir-29a Decreased In Ad Brains Targets Nav3mentioning

confidence: 99%

“…To identify miRNAs aberrantly expressed in the brains of human neurodegenerative diseases, we initially studied miRNA expression profiles of the frontal cortex of three amyotrophic lateral sclerosis (ALS) patients on a microarray containing 723 miRNAs (23). The human frontal cortex total RNA of a 79 year-old Caucasian man who died of bladder cancer (AM6810, Ambion) was utilized as a universal reference.…”

Section: Mir-29a Decreased In Ad Brains Targets Nav3mentioning

confidence: 99%

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MicroRNAs and Their Therapeutic Potential for Human Diseases: Aberrant MicroRNA Expression in Alzheimer’s Disease Brains

Satoh

2010

J Pharmacol Sci

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Abstract. MicroRNAs (miRNAs) are a group of small noncoding RNAs that regulate translational repression of multiple target mRNAs. The miRNAs in a whole cell regulate greater than 30% of all protein-coding genes. The vast majority of presently identified miRNAs are expressed in the brain in a spatially and temporally controlled manner. They play a key role in neuronal development, differentiation, and synaptic plasticity. However, at present, the pathological implications of deregulated miRNA expression in neurodegenerative diseases remain largely unknown. This review will briefly summarize recent studies that focus attention on aberrant miRNA expression in Alzheimer's disease brains.

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Section: Mir-29a Decreased In Ad Brains Targets Nav3mentioning

confidence: 88%

Section: Mir-29a Decreased In Ad Brains Targets Nav3mentioning

confidence: 99%

Section: Mir-29a Decreased In Ad Brains Targets Nav3mentioning

confidence: 99%

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MicroRNAs and Their Therapeutic Potential for Human Diseases: Aberrant MicroRNA Expression in Alzheimer’s Disease Brains

Satoh

2010

J Pharmacol Sci

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“…It is widely accepted that deregulated expression levels of certain miRNAs directly participate in the development and progression of numerous types of human cancer. In addition to its role in cancer, miR-29a has also been demonstrated to be associated with osteoblastic differentiation (15), myogenesis (16), sclerosis (17), fibrosis (18), HIV-1 replication (19), diabetes (20) and Alzheimer's disease (21). In the current study, it was identified that overexpression of miR-29a markedly suppressed the migratory and invasive capacities of gastric cancer cells.…”

Section: Discussionmentioning

confidence: 62%

MicroRNA-29a inhibits cell migration and invasion via targeting Roundabout homolog 1 in gastric cancer cells

Liu

Cai

Sun

et al. 2015

Molecular Medicine Reports

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Abstract. Deregulation of Roundabout homolog 1 (Robo1) has been demonstrated to be associated with several types of human cancer, including gastric cancer. However, the detailed role of Robo1 and its regulatory mechanism in gastric cancer remain largely unclear. In the current study, it was demonstrated that the expression of microRNA (miR)-29a was frequently reduced in gastric cancer tissues, compared with their matched normal adjacent tissues. Similar results were additionally observed in AGS and SGC-7901 human gastric cancer cells. Overexpression of miR-29a led to reduced migration and invasion of AGS cells. To explore the targets of miR-29a in gastric cancer, bioinformatics analysis was conducted and Robo1 was identified as a putative target of miR-29a. Further western blotting and luciferase activity assay data confirmed that miR-29a was able to negatively regulate the protein expression of Robo1, through directly binding to the 3'-untranslated region of Robo1 mRNA in gastric cancer cells. In addition, it was demonstrated that Robo1 was frequently upregulated in gastric cancer tissues compared with their matched adjacent normal tissues, and a significant inverse correlation was identified between miR-29a and Robo1 expression. In addition, knockdown of Robo1 by small interfering RNA markedly inhibited the migratory and invasive capabilities of AGS cells, which the results obtained with overexpression of miR-29a. In conclusion, to the best of our knowledge the current study suggested for the first time, that miR-29a inhibits migration and invasion in part via direct inhibition of Robo1 in gastric cancer cells. Therefore, Robo1 and miR-29a may serve as diagnostic or therapeutic targets for gastric cancer.

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“…miR-29 family members are demonstrated to be involved in the regulation of neuron navigator 3 (NAV3) in the context of AD [84]. Studies in lung cancer and acute myelogenous leukemia have shown that the same family of miRNA directly target DNA methyltransferases DNMT3A and DNMT3B [85,86].…”

Section: Neurodegenerative Diseases Meet Cancers In a Mirna Worldmentioning

confidence: 99%

17 Neurodegenerative Disorders

Runge¹,

Morelli²

2011

Essentials of Clinical MR

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Abstract:Neurodegenerative disorders, such as Alzheimer's disease (AD), Parkinson's disease (PD) and frontotemporal dementias (FTD), are considered distinct entities, however, there is increasing evidence of an overlap from the clinical, pathological and genetic points of view. All neurodegenerative diseases are characterized by neuronal loss and death in specific areas of the brain, for example, hippocampus and cortex for AD, midbrain for PD, frontal and temporal lobes for FTD. Loss of neurons is a relatively late event in the progression of neurodegenerative diseases that is typically preceded by other events such as metabolic changes, synaptic dysfunction and loss, neurite retraction, and the appearance of other abnormalities, such as axonal transport defects. The brain's ability to compensate for these dysfunctions occurs over a long period of time and results in late clinical manifestation of symptoms, when successful pharmacological intervention is no longer feasible. Currently, diagnosis of AD, PD and different forms of dementia is based primarily on analysis of the patient's cognitive function. It is therefore important to find non-invasive diagnostic methods useful to detect neurodegenerative diseases during early, preferably asymptomatic stages, when a pharmacological intervention is still possible. Altered expression of microRNAs (miRNAs) in many disease states, including neurodegeneration, and increasing relevance of miRNAs in biofluids in different pathologies has prompted the study of their possible application as neurodegenerative diseases biomarkers in order to identify new therapeutic targets. Here, we review what is known about the role of miRNAs OPEN ACCESSMolecules 2014, 19 6892 in the pathogenesis of neurodegeneration and the possibilities and challenges of using these small RNA molecules as a signature for neurodegenerative conditions.

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Aberrant microRNA expression in the brains of neurodegenerative diseases: miR‐29a decreased in Alzheimer disease brains targets neurone navigator 3

Abstract: These observations suggest the hypothesis that underexpression of miR-29a affects neurodegenerative processes by enhancing neuronal NAV3 expression in AD brains.

Cited by 272 publications

References 36 publications

MicroRNAs and Their Therapeutic Potential for Human Diseases: Aberrant MicroRNA Expression in Alzheimer’s Disease Brains

MicroRNAs and Their Therapeutic Potential for Human Diseases: Aberrant MicroRNA Expression in Alzheimer’s Disease Brains

MicroRNA-29a inhibits cell migration and invasion via targeting Roundabout homolog 1 in gastric cancer cells

17 Neurodegenerative Disorders

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