2015
DOI: 10.1155/2015/409432
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Aberrant Phenotype in Human Endothelial Cells of Diabetic Origin: Implications for Saphenous Vein Graft Failure?

Abstract: Type 2 diabetes (T2DM) confers increased risk of endothelial dysfunction, coronary heart disease, and vulnerability to vein graft failure after bypass grafting, despite glycaemic control. This study explored the concept that endothelial cells (EC) cultured from T2DM and nondiabetic (ND) patients are phenotypically and functionally distinct. Cultured human saphenous vein- (SV-) EC were compared between T2DM and ND patients in parallel. Proliferation, migration, and in vitro angiogenesis assays were performed; w… Show more

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Cited by 11 publications
(10 citation statements)
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“…The expression of NOS3 in healthy ECs was downregulated on all topographies compared to healthy EC on Unpatterned, (Figure 5C). The production of nitric oxide in diabetic ECs is known to be severely impaired [53,54], and this was strongly indicated in the drastic downregulation of NOS3 (nitric oxide synthase) on diabetic ECs compared with healthy ECs on Unpatterned. In diabetic ECs, NOS3 expression was upregulated on all topographies compared to diabetic ECs on Unpatterned.…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…The expression of NOS3 in healthy ECs was downregulated on all topographies compared to healthy EC on Unpatterned, (Figure 5C). The production of nitric oxide in diabetic ECs is known to be severely impaired [53,54], and this was strongly indicated in the drastic downregulation of NOS3 (nitric oxide synthase) on diabetic ECs compared with healthy ECs on Unpatterned. In diabetic ECs, NOS3 expression was upregulated on all topographies compared to diabetic ECs on Unpatterned.…”
Section: Resultsmentioning
confidence: 99%
“…The vast differences between diabetic and nondiabetic ECs are also manifested in significantly variable rates of healing and surgical success (e.g. patency rates) between the two [54]. For instance, patency rates and survival rates after stenting or vascular bypass are significantly lower in diabetic patients compared with nondiabetic patients [57,58].…”
Section: Discussionmentioning
confidence: 99%
“…However, these same processes can also trigger the development of pathological NIH, characterised by chronic vascular EC inflammation and uncontrollable SMC migration and proliferation (Figure 1) [22]. Importantly, human ECs and SMCs from T2DM patients already show defects in such cellular functions compared to cells from NDM patients [2325]. NIH also narrows the blood vessel lumen and serves as a foundation for the development of atherosclerotic plaques, which contribute to SV restenosis [26].…”
Section: Diabetes and Vein Graft Failurementioning
confidence: 99%
“…T2DM and metabolic syndrome cause endothelial dysfunction17. Under physiological conditions, β-oxidation of FA accounts for 70–80% of ATP generation in the heart.…”
mentioning
confidence: 99%