Aberrant T cell activation and heightened apoptotic turnover in end-stage renal failure patients: a comparative evaluation between non-dialysis, haemodialysis, and peritoneal dialysis

Moser, Bernhard; Roth, Georg A.; Brunner, Markus; Lilaj, Tatjana; Deicher, Robert; Wolner, Ernst; Kovařík, Josef; Boltz‐Nitulescu, George; Vychytil, Andreas; Ankersmit, Hendrik Jan

doi:10.1016/s0006-291x(03)01389-5

Cited by 71 publications

(48 citation statements)

References 21 publications

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“…22,23 Besides age, several researches also reported a lymphocyte fluctuation in CKD though most evidences were based on ESRD patients. 12,[24][25][26][27][28] Bunch of studies also indicated that both hemodialysis and uremic status can affect immune system and this disturbed immune system undoubtedly contributed to the infection susceptibility and CVD morbidity in these patients. [29][30][31][32] B lymphocytes have long been known as the unique cell type in humoral immunity through the production of antibodies.…”

Section: Discussionmentioning

confidence: 99%

“…24,[55][56][57][58] Recent studies argued premature aging of T lymphocyte compartment in ESRD patients 59,60 and CD4 + T lymphocyte count could independently predict infection in antineutrophil cytoplasmic autoantibody associated vasculitis patients. 61 It is reasonable to speculate that lymphocyte alteration in CKD patients may not only associate with renal function deterioration but also could predict cardiovascular or infection events in these patients.…”

Section: Discussionmentioning

confidence: 99%

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Lymphocyte depletion and subset alteration correlate to renal function in chronic kidney disease patients

et al. 2015

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Lymphocyte depletion and subset alteration correlate to renal function in chronic kidney disease patients

et al. 2015

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“…The ICs should load on FDCs and bypass limitations imposed by MHC and T cells. Similarly, specific IgM responses should be inducible in animals or people with congenital and/or acquired T cell insufficiencies (62,63), including HIV infected (64), aged (65), diabetic (66), uremic (67), and neonates (68,69). We look forward to experiments designed to test these postulates.…”

Section: Discussionmentioning

confidence: 99%

T-Independent Antibody Responses to T-Dependent Antigens: A Novel Follicular Dendritic Cell-Dependent Activity

Shikh

Sayed²,

Szakal³

et al. 2009

The Journal of Immunology

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Follicular dendritic cells (FDCs) periodically arrange membrane-bound immune complexes (ICs) of T-dependent Ags 200–500Å apart, and in addition to Ag, they provide B cells with costimulatory signals. This prompted the hypothesis that Ag in FDC-ICs can simultaneously cross-link multiple BCRs and induce T cell-independent (TI) B cell activation. TI responses are characterized by rapid IgM production. OVA-IC-bearing FDCs induced OVA-specific IgM in anti-Thy-1-pretreated nude mice and by purified murine and human B cells in vitro within just 48 h. Moreover, nude mice immunized with OVA-ICs exhibited well-developed GL-7+ germinal centers with IC-retaining FDC-reticula and Blimp-1+ plasmablasts within 48 h. In contrast, FDCs with unbound-OVA, which would have free access to BCRs, induced no germinal centers, plasmablasts, or IgM. Engagement of BCRs with rat-anti-mouse IgD (clone 11–26) does not activate B cells even when cross-linked. However, B cells were activated when anti-IgD-ICs, formed with Fc-specific rabbit anti-rat IgG, were loaded on FDCs. B cell activation was indicated by high phosphotyrosine levels in caps and patches, expression of GL-7 and Blimp-1, and B cell proliferation within 48 h after stimulation with IC-bearing FDCs. Moreover, anti-IgD-IC-loaded FDCs induced strong polyclonal IgM responses within 48 h. Blockade of FDC-FcγRIIB inhibited the ability of FDC-ICs to induce T-independent IgM responses. Similarly, neutralizing FDC-C4BP or -BAFF, to minimize these FDC-costimulatory signals, also inhibited this FDC-dependent IgM response. This is the first report of FDC-dependent but TI responses to T cell-dependent Ags.

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“…There are some possible explanations for lymphocyte depletion in CKD patients, namely, increased turnover, disturbance of lymphocyte homeostasis due to uremia and increased peripheral lymphocyte apoptosis associated with activation stimulus [14,[31][32][33][34][35]. This lymphocyte depletion could be ; grey bars) T cells after short-term in vitro stimulation with phorbol-12 myristate 13-acetate plus Ionomycin in controls, as well as in responder and nonresponder CKD patients.…”

Section: Discussionmentioning

confidence: 99%

Inflammation, T-Cell Phenotype, and Inflammatory Cytokines in Chronic Kidney Disease Patients Under Hemodialysis and its Relationship to Resistance to Recombinant Human Erythropoietin Therapy

et al. 2008

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Background Resistance to recombinant human erythropoietin (rhEPO) occurs in some chronic kidney disease (CKD) patients, which may be due to enhanced systemic inflammatory response and to the erythropoiesis-suppressing effect of pro-inflammatory cytokines, some of which are produced by T cells. Aim of study The aim of this study was to investigate the relationship between resistance to rhEPO therapy in hemodialysis CKD patients and inflammatory markers [Creactive protein (CRP), soluble interleukin (IL)-2 receptor (sIL2R), and serum albumin levels], blood cell counts, Tcell phenotype, cytokine production by T cells, and serum cytokine levels. Materials and Methods We studied 50 hemodialysis CKD patients, 25 responders and 25 nonresponders to rhEPO, and compared them to each other and with 25 healthy controls. When compared to controls, CKD patients showed increased serum levels of CRP, IL-6, and sIL2R and a T-cell lymphopenia, due to decreased numbers of both CD4 + and CD8 + T cells. T cells from CKD patients had an immunophenotype compatible with chronic T-cell stimulation as shown by the increased percentage of CD28

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Aberrant T cell activation and heightened apoptotic turnover in end-stage renal failure patients: a comparative evaluation between non-dialysis, haemodialysis, and peritoneal dialysis

Cited by 71 publications

References 21 publications

Lymphocyte depletion and subset alteration correlate to renal function in chronic kidney disease patients

Lymphocyte depletion and subset alteration correlate to renal function in chronic kidney disease patients

T-Independent Antibody Responses to T-Dependent Antigens: A Novel Follicular Dendritic Cell-Dependent Activity

Inflammation, T-Cell Phenotype, and Inflammatory Cytokines in Chronic Kidney Disease Patients Under Hemodialysis and its Relationship to Resistance to Recombinant Human Erythropoietin Therapy

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