Aberrant ventral striatal responses during incentive processing in unmedicated patients with obsessive-compulsive disorder

Jung, Wi Hoon; Kang, Do‐Hyung; Han, Jin Tae; Jang, Joon Hwan; Gu, Bon-Mi; Choi, Jung Seok; Jung, Myung Hun; Choi, Chi Hoon; Kwon, Jun Soo

doi:10.1111/j.1600-0447.2010.01659.x

Cited by 59 publications

(55 citation statements)

References 48 publications

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“…Using a monetary incentive-delay task, Jung et al . [515] found increased frontostriatal activation during monetary-reward outcome, and decreased lateral prefrontal and inferior parietal cortex activation during loss anticipation, but no group differences during monetary-reward anticipation. However, Figee and colleagues [516] did find relatively decreased NAc activity during reward anticipation in OCD, particularly in those patients with contamination fear.…”

Section: Reviewmentioning

confidence: 99%

Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings

Dichter

Damiano

Allen

2012

J Neurodevelop Disord

254

207

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This review summarizes evidence of dysregulated reward circuitry function in a range of neurodevelopmental and psychiatric disorders and genetic syndromes. First, the contribution of identifying a core mechanistic process across disparate disorders to disease classification is discussed, followed by a review of the neurobiology of reward circuitry. We next consider preclinical animal models and clinical evidence of reward-pathway dysfunction in a range of disorders, including psychiatric disorders (i.e., substance-use disorders, affective disorders, eating disorders, and obsessive compulsive disorders), neurodevelopmental disorders (i.e., schizophrenia, attention-deficit/hyperactivity disorder, autism spectrum disorders, Tourette’s syndrome, conduct disorder/oppositional defiant disorder), and genetic syndromes (i.e., Fragile X syndrome, Prader–Willi syndrome, Williams syndrome, Angelman syndrome, and Rett syndrome). We also provide brief overviews of effective psychopharmacologic agents that have an effect on the dopamine system in these disorders. This review concludes with methodological considerations for future research designed to more clearly probe reward-circuitry dysfunction, with the ultimate goal of improved intervention strategies.

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Section: Reviewmentioning

confidence: 99%

Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings

Dichter

Damiano

Allen

2012

J Neurodevelop Disord

254

207

View full text Add to dashboard Cite

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“…Despite strong arguments for a role of altered processing of negative and ambiguous feedback in the pathophysiology of OCD, no neuroimaging studies haveto the best of our knowledgeinvestigated the processing of ambiguous feedback in OCD. Furthermore, no imaging studies have explored the processing of feedback valence in OCD outside the context of monetary incentives (Remijnse et al, 2006;Figee et al, 2011;Jung et al, 2011) with the latter studies yielding only partially consistent results. Remijnse et al (Remijnse et al, 2006) explored brain activation of OCD patients during a reversal task with monetary reward and loss feedback and showed attenuated activation of orbitofrontal cortex (OFC) and caudate nucleus in OCD patients to reward feedback.…”

Section: Introductionmentioning

confidence: 97%

“…During loss feedback, however, no differential brain activation was observed. More recent studies reported diminished activation of the nucleus accumbens during reward anticipation and of medial frontal cortex during reward delivery in patients (Figee et al, 2011), and higher insular activation during loss anticipation relative to neutral anticipation (Jung et al, 2011). None of these studies reported activation of the cingulate cortices, which are typically involved in error and conflict processing in OCD (Saxena et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Altered emotional and BOLD responses to negative, positive and ambiguous performance feedback in OCD

Becker

Nitsch

Schlößer

et al. 2013

Social Cognitive and Affective Neuroscience

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While abnormal processing of performance feedback has been associated with obsessive-compulsive disorder (OCD), neural responses to different kinds of feedback information, especially to ambiguous feedback are widely unknown. Using fMRI and a performance adaptive time-estimation task, we acquired blood oxygenation level-dependant responses and emotional ratings to positive, negative and ambiguous performance feedback in patients and healthy controls. Negative and ambiguous feedback led to increased levels of anxiety, guilt and shame in patients. Both negative and ambiguous feedback, as compared to positive feedback, induced increased activation of the insular cortex in patients. Furthermore, patients showed no differential activation to negative feedback in the putamen and to ambiguous feedback in the ventromedial prefrontal cortex (VMPFC). Finally, negative feedback induced increased activation in the midcingulate cortex in patients compared to controls. Findings indicate that both negative and ambiguous performance feedbacks are associated with abnormal negative emotions and altered brain activation, in particular increased insula activation, while activation in the putamen and VMPFC does not differentiate between feedback types in OCD patients. This suggests a parallel pattern of increased and decreased neural sensitivity to different kinds of feedback information and a general emotional hyperresponsivity to negative and ambiguous performance feedback in OCD.

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“…Способность принимать решения оценивалась с помощью карточного Айова-теста (Iowa gambling test) и отсроченного задания с денежным стимулом (Monetary incentive delayed task). Снижение показателей указанных тестов у пациентов с ОКР было связано с активацией ле-вой префронтальной коры и левого хвостатого ядра по данным нейровизуализации [33,34].…”

Section: о б з о р ы о с н о в н ы е х а р а к т е р и с т и к и л о unclassified

The role of frontal-subcortical circuits in the development of obsessive-compulsive disorders

Кутлубаев

2016

RJTAO

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Обсессивно-компульсивное расстройство (ОКР) -широко распространенное заболевание, частота которого достигает 1-3%. Эта форма невротического расстройства занимает 4-е место по распространенности среди психиче-ских заболеваний в мире [1].Обсессии могут проявляться непреодолимыми, возни-кающими вопреки воле пациента, мыслями (например, о за-грязнении, о возможной потере самоконтроля и др.), образами (например, сцены насилия) или желаниями (например, до-тронуться до кого-либо). Они являются источником психо-логического дистресса и тревоги. Попытки подавить или иг-норировать обсессии с помощью других мыслей или дейст-вий приводят к развитию компульсий. Например, пациент постоянно моет руки (компульсия), чтобы избавится от мыс-ли об их загрязнении (обсессия), или считает про себя, чтобы нейтрализовать навязчивое желание выполнить какое-то не-желательное для него действие (например, дотронуться до какого-то предмета). Компульсии приводят к временному снижению психологического дискомфорта, который вызы-вают обсессии. Вследствие этого происходит закрепление связи между развитием обсессии и реакцией на нее в виде компульсии, формируется «порочный круг» [1,2]. Развитие ОКР зачастую способствует возникновению депрессии и мо-жет стать причиной инвалидизации пациента [1].

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Aberrant ventral striatal responses during incentive processing in unmedicated patients with obsessive-compulsive disorder

Abstract: These findings provide neural evidence for altered incentive processing in unmedicated patients with OCD, suggesting an elevated sensitivity to negatively affect stimuli as well as dysfunction of the ventral striatum.

Cited by 59 publications

References 48 publications

Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings

Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings

Altered emotional and BOLD responses to negative, positive and ambiguous performance feedback in OCD

The role of frontal-subcortical circuits in the development of obsessive-compulsive disorders

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