Abietic acid isolated from pine resin (Resina Pini) enhances angiogenesis in HUVECs and accelerates cutaneous wound healing in mice

Park, Jun Yeon; Lee, Yun Kyung; Lee, Dong‐Soo; Yoo, Jeong-Eun; Shin, Myoung‐Sook; Yamabe, Noriko; Kim, Su‐Nam; Lee, Seulah; Kim, Ki‐Hyun; Lee, Hae‐Jeung; Roh, Seok Sun; Kang, Ki Sung

doi:10.1016/j.jep.2017.03.055

Cited by 54 publications

(35 citation statements)

References 30 publications

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“…Although dietary PUFA especially CLA has an effect in the IgG increase, the doses were very low in our study compare to the others. In our opinion, the novel RA has a potential role in the increase of IgG based on the current research of anti-inflammatory, immunomodulatory and inhibitory effect on pathogenic bacteria (Takahashi et al, 2003;Kang et al, 2008;Park et al, 2017;Vienola et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

“…RAC, a novel dietary product, typically comprises resin acids (~8%) and free fatty acids (~90%), and 2 to 3% neutral components. RA of RAC has been used to enhance immunity and regulate inflammation and wound healing (Kang et al, 2008;Park et al, 2017). However, Conjugated linolenic, pinolenic and oleic acids are characteristic fatty acid components of RAC and the effects of their supplementation in gestating and lactating diets have been well studied (Bontempo et al, 2004;Corino et al, 2009;Yao et al, 2012;Yin et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

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Late gestation diet supplementation of resin acid-enriched composition increases sow colostrum immunoglobulin G content, piglet colostrum intake and improve sow gut microbiota

Hasan

Saha

Junnikkala

et al. 2019

animal

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Resin acid-enriched composition (RAC) mainly containing tall oil fatty acid with an active component of resin acid (RA) can improve the microbial population in the digestive system, change the microbial fermentation, and improve the feed conversion ratio. We investigated the effects of dietary supplementation of RAC on sow colostrum yield (CY), colostrum composition and gut microbiota. Tall oil fatty acid and RA are commonly termed RAC and CLA, pinolenic, abietic, dehydrobiotic acids are characteristic components of RAC. The experiment was conducted in three trials in three respective herds. Sows were fed with a control diet and the same diet supplemented with 5 g RAC/day per sow during the last week of gestation. The 16S ribosomal RNA gene sequencing technique was used to assess sows’ faecal microbiota populations at farrowing. Colostrum nutritional composition, acute phase proteins (APPs) and immunoglobulin (Ig) content were also assessed. Individual piglets were weighed at birth and 24 h after the birth of first piglets in order to calculate CY and later at 3 to 4 weeks to calculate average daily gain. The RAC-fed sows had significantly higher IgG levels (P<0.05) in all three herds but treatment did not influence colostrum IgA and IgM concentration. There were no significant differences in colostrum protein, lactose and fat content in sows of the two diet groups (P>0.05), but those fed RAC had higher levels of colostrum serum amyloid A. Colostrum yield was significantly higher in RAC-fed sows in herds 2 and 3 with heavier piglets between 3 and 4 weeks of age (P<0.05), but not in herd 1 (P>0.05). Resin acid-enriched composition supplementation significantly increased some beneficial and fermentative bacteria (Romboutsia and Clostridium sensu stricto) than the control diet (P<0.01) while some opportunistic pathogens (Barnesiella, Sporobacter, Intestinimonas and Campylobacter), including Proteobacteria, were suppressed. Therefore, RAC added to the sow diet at late pregnancy increases colostrum IgG, colostrum availability for neonate piglets, and seems to promote better maternal intestinal microbial sources.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Late gestation diet supplementation of resin acid-enriched composition increases sow colostrum immunoglobulin G content, piglet colostrum intake and improve sow gut microbiota

Hasan

Saha

Junnikkala

et al. 2019

animal

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“…These steps can be characterized into four highly programmed phases such as hemostasis, inflammation, proliferation and remodeling [2,6,[12][13][14][15][16]. All phases of healing must occur in suitable sequence for successful healing as a natural phenomenon [6,12,13] but sometimes complex multifactorial process of wound healing can be delayed or failed by unwanted effects such as presence of free radicals [12,17] or microbial infections [5,12,16,17].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Wound Healing Properties of Luteolin Ointments on Excision and Incision Wound Models in Diabetic and Non-Diabetic Rats

Özay¹,

Güzel²,

Erdoğdu³

et al. 2018

Rec.Nat.Prod.

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Luteolin, which is structurally classified under the flavonoids, is naturally distributed abundant among medicinal plants, vegetables and fruits. The wound healing effects of Luteolin ointments were evaluated for incision and excision wound models on non-diabetic and Streptozotocin induced diabetic rats by using macroscopical, biomechanical, biochemical and histopathological methods. Two different concentrations (0.5 % and 1 % (w/w)) of the Luteolin ointment were prepared with the mixture of glycol stearate:propylene glycol:liquid paraffin (3:6:1) and 0.5 g of the ointments were applied topically on wounds once daily for 7 and 14 days. During the experiments, wounds were visually observed, photographically documented and wound areas were measured. After 7 and 14 days treatment, animals were sacrificed under anesthesia and hydroxyproline measurement and biomechanical analysis were performed. Histopathology of the wound area was evaluated considering features of re-epithelialization, thickness of the granulation tissue, angiogenesis, presence of inflammation, number of mast cells. Outcomes of this study revealed that Luteolin ointments improved wound healing process of skin tissue both in non-diabetic and diabetic wounds. The best wound healing activity was observed in incision and excision wounds (97.6 %, 96.1 %, respectively) treated with 0.5 % (w/w) Luteolin ointment on day 14 according to macroscopic results.

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“…Angiogenesis plays an essential role in physiological and pathological processes such as wound healing, embryonic development, tumour growth and chronic inflammation . Actually, angiogenesis has a dual function, which provides the oxygen and essential nutrients to the lesion site and accelerating granulation tissue formation .…”

Section: Resultsmentioning

confidence: 99%

Novel insight into wound healing properties of methanol extract of Capparis ovata Desf. var. palaestina Zohary fruits

Okur

Ayla

Polat

et al. 2018

Journal of Pharmacy and Pharmacology

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Abietic acid isolated from pine resin (Resina Pini) enhances angiogenesis in HUVECs and accelerates cutaneous wound healing in mice

Cited by 54 publications

References 30 publications

Late gestation diet supplementation of resin acid-enriched composition increases sow colostrum immunoglobulin G content, piglet colostrum intake and improve sow gut microbiota

Late gestation diet supplementation of resin acid-enriched composition increases sow colostrum immunoglobulin G content, piglet colostrum intake and improve sow gut microbiota

Evaluation of the Wound Healing Properties of Luteolin Ointments on Excision and Incision Wound Models in Diabetic and Non-Diabetic Rats

Novel insight into wound healing properties of methanol extract of Capparis ovata Desf. var. palaestina Zohary fruits

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