Abiotic Ribose Synthesis Under Aqueous Environments with Various Chemical Conditions

Ono, Chinatsu; Sunami, Sako; Ishii, Yuka; Kim, Hyo-Joong; Kakegawa, Takeshi; Benner, Steven A.; Furukawa, Yoshihiro

doi:10.1089/ast.2023.0071

Cited by 4 publications

(3 citation statements)

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“…The rest of this review summarizes those reactions that contribute to the probability of there being other steps in the pathway based on the observations of evolutionary scientists. In an earlier review, (i) the formose reaction, (ii) the reactions of ribose phosphorylation and (iii) the formation of RNA were regarded as related but independent reactions [ 49 ]. Earlier, the major reason for the objection against the formose reaction serving as a sugar source for RNA synthesis was the low yield of ribose [ 27 , 29 , 50 ].…”

Section: The Plausibility Of the Formose–ribose–rna Pathwaymentioning

confidence: 99%

“…However, once it was formed, the hydrolysis of preRNA followed the degradation pattern of other RNA molecules and generated nucleoside monophosphates (NMPs). Although activated ribonucleotides can polymerize to nucleotides, how has been explained based on plausible reactions [ 49 ]. Briefly, the hydrolysis of non-genetic preRNA-generated nucleoside monophosphates were phosphorylated to nucleoside triphosphates.…”

Section: The Plausibility Of the Formose–ribose–rna Pathwaymentioning

confidence: 99%

“…(14). Protein targeting: information reaches intra- or extracellular destination [ 49 ]. Reproduced with permission from Banfalvi, G. “Prebiotic Pathway from ribose to RNA formation”.…”

Section: Figurementioning

confidence: 99%

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The Origin of RNA and the Formose–Ribose–RNA Pathway

Banfalvi

2024

IJMS

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Prebiotic pre-Darwinian reactions continued throughout biochemical or Darwinian evolution. Early chemical processes could have occurred on Earth between 4.5 and 3.6 billion years ago when cellular life was about to come into being. Pre-Darwinian evolution assumes the development of hereditary elements but does not regard them as self-organizing processes. The presence of biochemical self-organization after the pre-Darwinian evolution did not justify distinguishing between different types of evolution. From the many possible solutions, evolution selected from among those stable reactions that led to catalytic networks, and under gradually changing external conditions produced a reproducible, yet constantly evolving and adaptable, living system. Major abiotic factors included sunlight, precipitation, air, minerals, soil and the Earth’s atmosphere, hydrosphere and lithosphere. Abiotic sources of chemicals contributed to the formation of prebiotic RNA, the development of genetic RNA, the RNA World and the initial life forms on Earth and the transition of genRNA to the DNA Empire, and eventually to the multitude of life forms today. The transition from the RNA World to the DNA Empire generated new processes such as oxygenic photosynthesis and the hierarchical arrangement of processes involved in the transfer of genetic information. The objective of this work is to unite earlier work dealing with the formose, the origin and synthesis of ribose and RNA reactions that were published as a series of independent reactions. These reactions are now regarded as the first metabolic pathway.

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