Abl2 Kinase Differentially Regulates iGluRs Current Activity and Synaptic Localization

Kabirova, M.; Reichenstein, Michal; Borovok, Natalia; Sheinin, Anton; Gorobets, Denis; Michaelevski, Izhak

doi:10.1007/s10571-023-01317-9

Cited by 3 publications

(1 citation statement)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A recent study reports that postsynaptic axon guidance effector abl2 kinase reduces iGluR currents. Abl2 knockdown causes dynamic reduction in the number of distal excitatory synapses in hippocampal cell cultures ( 30 ). Similar study has not been done in the retina.…”

Section: Glutamate In Prenatal Retinal Developmentmentioning

confidence: 99%

Role of glutamate in the development of visual pathways

Majumdar

2023

Front. Ophthalmol.

View full text Add to dashboard Cite

Glutamate is an important amino acid, metabolite and excitatory neurotransmitter, which is found in its free form in the extracellular spaces of the central nervous system (CNS). More than half of all synapses in CNS release glutamate. It is the main neurotransmitter driving the light responses in the retina. All types of photoreceptors, bipolar, ganglion and one type of glycinergic amacrine cells express specific subtypes of vesicular glutamate transporters and are the main source of endogenous glutamate in retina, besides Müller glia that are responsible for glutamate homeostasis, release and reuptake. Reduced or excessive extracellular glutamate was detected in the synaptic clefts of several naturally occurring or transgenic eye disease models, in which network rewiring and altered functions were observed. These led to the hypothesis that glutamate is one of the extrinsic signals for visual pathway development. This minireview examines experimental evidences supporting, or refuting, the influence of glutamate on prenatal and postnatal retinal development.

show abstract

Section: Glutamate In Prenatal Retinal Developmentmentioning

confidence: 99%

Role of glutamate in the development of visual pathways

Majumdar

2023

Front. Ophthalmol.

View full text Add to dashboard Cite

show abstract

Impact of Abl2/Arg deficiency on anxiety and depressive behaviors in mice

Yao,

Chen,

Chen

et al. 2024

Behavioural Brain Research

View full text Add to dashboard Cite

Overabundant endocannabinoids in neurons are detrimental to cognitive function

Zhu,

Zhang,

et al. 2024

Preprint

View full text Add to dashboard Cite

2-Arachidonoylglycerol (2-AG) is the most prevalent endocannabinoid involved in maintaining brain homeostasis. Previous studies have demonstrated that inactivating monoacylglycerol lipase (MAGL), the primary enzyme responsible for degrading 2-AG in the brain, alleviates neuropathology and prevents synaptic and cognitive decline in animal models of neurodegenerative diseases. However, we show that selectively inhibiting 2-AG metabolism in neurons impairs cognitive function in mice. This cognitive impairment appears to result from decreased expression of synaptic proteins and synapse numbers, impaired long-term synaptic plasticity and cortical circuit functional connectivity, and diminished neurogenesis. Interestingly, the synaptic and cognitive deficits induced by neuronal MAGL inactivation can be counterbalanced by inhibiting astrocytic 2-AG metabolism. Transcriptomic analyses reveal that inhibiting neuronal 2-AG degradation leads to widespread changes in expression of genes associated with synaptic function. These findings suggest that crosstalk in 2-AG signaling between astrocytes and neurons is crucial for maintaining synaptic and cognitive functions and that excessive 2-AG in neurons alone is detrimental to cognitive function.

show abstract

Abl2 Kinase Differentially Regulates iGluRs Current Activity and Synaptic Localization

Cited by 3 publications

References 54 publications

Role of glutamate in the development of visual pathways

Role of glutamate in the development of visual pathways

Impact of Abl2/Arg deficiency on anxiety and depressive behaviors in mice

Overabundant endocannabinoids in neurons are detrimental to cognitive function

Contact Info

Product

Resources

About