2021
DOI: 10.1016/j.radonc.2021.03.001
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Ablative radiotherapy for ultracentral lung cancers: Dosimetric, geometric, and volumetric predictors of outcomes and toxicity

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Cited by 16 publications
(17 citation statements)
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“…Median OS was 29 months and 1-year, and 2-year OS rates were 75% and 58%, respectively. Similar results were reported by Breen et al [ 21 ] and Lodeweges et al [ 19 ], with 1-year and 2-year OS rates of 78% and 57%, and 77% and 52%, respectively. One-year LC was 97% in the study reported by Guillaume et al [ 17 ], and 98% in the work by Lodeweges et al [ 19 ], slightly higher than our findings.…”
Section: Discussionsupporting
confidence: 90%
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“…Median OS was 29 months and 1-year, and 2-year OS rates were 75% and 58%, respectively. Similar results were reported by Breen et al [ 21 ] and Lodeweges et al [ 19 ], with 1-year and 2-year OS rates of 78% and 57%, and 77% and 52%, respectively. One-year LC was 97% in the study reported by Guillaume et al [ 17 ], and 98% in the work by Lodeweges et al [ 19 ], slightly higher than our findings.…”
Section: Discussionsupporting
confidence: 90%
“…The consequent wide variability of the PBT contouring could contribute to significant hotspots in crucial substructures, such as lobar or main bronchi [ 39 ]. The novelty of our study is the purpose to define prognostic factors for survival in a homogenous population of exclusively ultra-central lung tumors, which has been rarely investigated over the past years [ 21 ].…”
Section: Discussionmentioning
confidence: 99%
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“…In addition, the shortest distance (in 3-dimensions) from the surface of the spinal cord structure to the surface of both PTV structures was computed by a custom script written using the application programing interface (API) for the treatment planning system. 25 The treatment plans were grouped by proximity of the spinal cord to PTV_high and PTV_low in 1 mm increments (<1 mm, 1-2 mm, etc), and the mean value and interquartile range (IQR) were computed for select DVH-statistics for the high- and low-risk PTVs. A comparison of the mean values of the selected DVH-statistics for both the 1 to 2 mm group and the 2 to 3 mm group with the <1 mm group was performed.…”
Section: Methodsmentioning
confidence: 99%
“…For select DVH-statistics for the spinal cord, the single-fraction equivalent dose (SFED) 23 and normalized biological-equivalent dose (nBED, with a reference dose of 2 Gy per fraction) 24 were computed using an α/β ratio of 2 Gy for the spinal cord. In addition, the shortest distance (in 3-dimensions) from the surface of the spinal cord structure to the surface of both PTV structures was computed by a custom script written using the application programing interface (API) for the treatment planning system 25 . The treatment plans were grouped by proximity of the spinal cord to PTV_high and PTV_low in 1 mm increments (<1 mm, 1-2 mm, etc.…”
Section: Analysis and Reviewmentioning
confidence: 99%