ABM Clinical Protocol #32: Management of Hyperlactation

Johnson, Helen M.; Eglash, Anne; Mitchell, Katrina B.; Leeper, Kathy; Smillie, Christina; Moore-Ostby, Lindsay; Manson, Nadine; Simon, Liliana

doi:10.1089/bfm.2019.29141.hmj

Cited by 19 publications

(16 citation statements)

References 21 publications

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“…Birth control pills delivering E + P decreased the content of LALBA in breast milk and overall milk production, although the volumetric decrease was still within the normal range of output [80]. Birth control pills containing E are also used to treat hyperlactation in humans, although the mechanism is undefined [81]. In lactating cows, a single dose of synthetic E accelerated mammary involution coincident with a reduced concentration of LALBA and lactose in milk following final milk removal [82,83].…”

Section: Estrogens (E)mentioning

confidence: 99%

A Comparative Review of the Extrinsic and Intrinsic Factors Regulating Lactose Synthesis

Sadovnikova

García

Hovey

2021

J Mammary Gland Biol Neoplasia

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Milk is critical for the survival of all mammalian offspring, where its production by a mammary gland is also positively associated with its lactose concentration. A clearer understanding of the factors that regulate lactose synthesis stands to direct strategies for improving neonatal health while also highlighting opportunities to manipulate and improve milk production and composition. In this review we draw a cross-species comparison of the extra- and intramammary factors that regulate lactose synthesis, with a special focus on humans, dairy animals, and rodents. We outline the various factors known to influence lactose synthesis including diet, hormones, and substrate supply, as well as the intracellular molecular and genetic mechanisms. We also discuss the strengths and limitations of various in vivo and in vitro systems for the study of lactose synthesis, which remains an important research gap.

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Section: Estrogens (E)mentioning

confidence: 99%

A Comparative Review of the Extrinsic and Intrinsic Factors Regulating Lactose Synthesis

Sadovnikova

García

Hovey

2021

J Mammary Gland Biol Neoplasia

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“…Finally, authors should use reporting guidelines together with journal-specific instructions for authors when preparing a manuscript for publication. (Johnson et al, 2020) A Measurement Tool to Assess Systematic Reviews 2 (AMSTAR 2) (Shea et al, 2017) Systematic Reviews of Randomized or Nonrandomized Studies (Fair et al, 2021) Quality Assessment of Diagnostic Accuracy Studies 2 (QUADAS 2) (Whiting et al, 2011) Diagnostic Accuracy Studies (Raskovalova et al, 2015) Note. 1 Not lactation study.…”

Section: Discussionmentioning

confidence: 99%

Critical Appraisal Tools and Reporting Guidelines

Haile

2021

J Hum Lact

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“…We advocate that patients with galactoceles undergo stab incision and drain placement by surgeons, or drain placement by interventional radiology for definitive resolution of the galactocele. [9][10][11] Physicians may wish to utilize betadine for flushing an infected fluid cavity; however, this should not Soares • Management of Infected Breast Implant used in lactating breasts because the levels that concentrate in breastmilk are unsafe for the infant. 12 This patient developed her implant infection and abscess cavity surrounding the implant as a result of repeated instrumentation and incomplete drainage of her infected galactocele.…”

Section: Discussionmentioning

confidence: 99%

Management of Infected Galactocele and Breast Implant with Uninterrupted Breastfeeding

Kornfeld

Johnson

Soares

et al. 2021

Plastic and Reconstructive Surgery - Global Open

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Summary: Infected breast implants during lactation present a rare but challenging clinical scenario that may result in early cessation of breastfeeding and unnecessary morbidity to mother and infant. We present the case of a 39-year-old African American primigravid woman with a history of bilateral retropectoral textured implants placed three years prior. Five days after delivering a healthy, full-term infant via cesarean section, she sought evaluation for nipple pain and trauma. She was instructed to use a nipple shield and pump every 2–3 hours in addition to breastfeeding, which resulted in iatrogenic hyperlactation. One week postpartum, the patient was started on antibiotics for presumed mastitis. Ultrasound demonstrated a complex fluid collection at the 12 o’clock periareolar position, as well as peri-implant fluid. She subsequently underwent aspirations of a periareolar complex galactocele and aspirations of peri-implant fluid. She continued on antibiotics without improvement. The patient proceeded to implant removal and definitive drainage of the galactocele at four months postpartum. Throughout her course, the patient provided her infant with exclusive breastmilk, including breastfeeding in the perioperative area of the operating room. This case demonstrates an example of safe surgical removal of infected breast implants and management of an infected galactocele without interruption of breastfeeding.

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ABM Clinical Protocol #32: Management of Hyperlactation

Cited by 19 publications

References 21 publications

A Comparative Review of the Extrinsic and Intrinsic Factors Regulating Lactose Synthesis

A Comparative Review of the Extrinsic and Intrinsic Factors Regulating Lactose Synthesis

Critical Appraisal Tools and Reporting Guidelines

Management of Infected Galactocele and Breast Implant with Uninterrupted Breastfeeding

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