Abnormal activation of the Wnt3a/β-catenin signaling pathway promotes the expression of T-box transcription factor 3(TBX3) and the epithelial-mesenchymal transition pathway to mediate the occurrence of adenomyosis

Comprehensive analysis of the clinical significance and molecular mechanism of T-box transcription factor 3 in osteosarcoma

“…Furthermore, the role of TBX3 in enhancing epithelial-mesenchymal transition across diverse cancers suggests a potential link to tumor dissemination and invasion 48 , 49 . This seems to be related to its ability to specifically bind to the T-box binding site in the E-cadherin gene promoter, exerting E-cadherin inhibition effects and facilitating self-triggered nuclear translocation 50 , 51 . Epithelial-mesenchymal transition is recognized to be a critical link in the progression and metastasis of various malignancies, influencing the characteristics and treatment resistance of metastatic tumors.…”

Epithelial–mesenchymal plasticity in cancer: signaling pathways and therapeutic targets

“… 97 Besides, Wnt/β‐catenin can upregulate the T‐box TF 3 (TBX3) expression as well as enhance EMT simultaneously, and this may be associated with the function of TBX3 in upregulating Slug expression. 98 Interferon‐induced protein with tetratricopeptide repeats 1 (IFIT1), an inflammation‐related protein dysregulated in cancer, is associated with the migration and invasion of pancreatic cancer cells. And it has been reported that Wnt/β‐catenin signaling can mediate the tumor‐promoting function of IFIT1 via activating EMT.…”