Abnormal brain iron accumulation in obstructive sleep apnea: A quantitative <scp>MRI</scp> study in the <scp>HypnoLaus</scp> cohort

Marchi, Nicola Andrea; Pizzarotti, Beatrice; Solelhac, Geoffroy; Berger, Mathieu; Haba‐Rubio, José; Preisig, Martin; Vollenweider, Péter; Marques‐Vidal, Pedro; Lutti, Antoine; Kherif, Ferath; Heinzer, Raphaël; Draganski, Bogdan

doi:10.1111/jsr.13698

Cited by 9 publications

(2 citation statements)

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“…Simultaneously, Liu et al ( 17 ) reported that two ferroptosis-related genes can serve as biomarkers for diagnosing OSA. Abnormal iron metabolism is associated with disease severity and poor oxygenation in patients with OSA ( 18 ). However, the specific regulatory mechanism of ferroptosis in the pathophysiological process of OSA and its clinical application still need to be further studied and explored.…”

Section: Introductionmentioning

confidence: 99%

Ferroptosis-related genes are considered as potential targets for CPAP treatment of obstructive sleep apnea

Huang,

Zhang,

Cao

et al. 2023

Front. Neurol.

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Obstructive sleep apnea (OSA) is a common syndrome characterized by upper airway dysfunction during sleep. Continuous positive airway pressure (CPAP) is the most frequently utilized non-surgical treatment for OSA. Ferroptosis play a crucial role in the physiological diseases caused by chronic intermittent hypoxia, but its involvement in the development of OSA and the exact mechanisms have incompletely elucidated. GSE75097 microarray dataset was used to identify differentially expressed genes between OSA patients and CPAP-treated OSA patients. Subsequently, Gene Ontology (GO) annotation, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway, STRING database, and FerrDb database were conducted to analyze the biological functions of differentially expressed genes and screen ferroptosis-related genes. Finally, GSE135917 dataset employed for validation. There were 1,540 differentially expressed genes between OSA patients and CPAP-treated OSA patients. These differentially expressed genes were significantly enriched in the regulation of interleukin-1-mediated signaling pathway and ferroptosis-related signaling pathway. Subsequently, 13 ferroptosis-related genes (DRD5, TSC22D3, TFAP2A, STMN1, DDIT3, MYCN, ELAVL1, JUN, DUSP1, MIB1, PSAT1, LCE2C, and MIR27A) were identified from the interaction between differentially expressed genes and FerrDb database, which are regarded as the potential targets of CPAP-treated OSA. These ferroptosis-related genes were mainly involved in cell proliferation and apoptosis and MAPK signaling pathway. Furthermore, DRD5 and TFAP2A were downregulated in OSA patients, which showed good diagnostic properties for OSA, but these abnormal signatures are not reversed with short-term effective CPAP therapy. In summary, the identification of 13 ferroptosis-related genes as potential targets for the CPAP treatment of OSA provides valuable insights into the development of novel, reliable, and accurate therapeutic options.

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Section: Introductionmentioning

confidence: 99%

Ferroptosis-related genes are considered as potential targets for CPAP treatment of obstructive sleep apnea

Huang,

Zhang,

Cao

et al. 2023

Front. Neurol.

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“…In the article by Marchi et al (2022) there are typographical errors in the affiliation and funding. It should have been “Center” instead of “Centre”.…”

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confidence: 99%

Corrigendum

2023

Journal of Sleep Research

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In the article by Marchi et al. (2022) there are typographical errors in the affiliation and funding. It should have been "Center" instead of "Centre".In the funding, it should have been "Université de Lausanne" instead of "Universit de Lausanne" and "Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung" instead of "Schweizerischer Nationalfonds zur Frderung der Wissenschaftlichen Forschung". In the abstract/main text, obstructive sleep apnea (OSA) is not consistently abbreviated as "OSA" and Alzheimer's disease is not consistently abbreviated as "AD".

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Associations between the multitrajectory neuroplasticity of neuronavigated rTMS‐mediated angular gyrus networks and brain gene expression in AD spectrum patients with sleep disorders

Yao,

Hou,

Zhou

et al. 2024

Alzheimer's & Dementia

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INTRODUCTIONThe multifactorial influence of repetitive transcranial magnetic stimulation (rTMS) on neuroplasticity in neural networks is associated with improvements in cognitive dysfunction and sleep disorders. The mechanisms of rTMS and the transcriptional‐neuronal correlation in Alzheimer's disease (AD) patients with sleep disorders have not been fully elucidated.METHODSForty‐six elderly participants with cognitive impairment (23 patients with low sleep quality and 23 patients with high sleep quality) underwent 4‐week periods of neuronavigated rTMS of the angular gyrus and neuroimaging tests, and gene expression data for six post mortem brains were collected from another database. Transcription‐neuroimaging association analysis was used to evaluate the effects on cognitive dysfunction and the underlying biological mechanisms involved.RESULTSDistinct variable neuroplasticity in the anterior and posterior angular gyrus networks was detected in the low sleep quality group. These interactions were associated with multiple gene pathways, and the comprehensive effects were associated with improvements in episodic memory.DISCUSSIONMultitrajectory neuroplasticity is associated with complex biological mechanisms in AD‐spectrum patients with sleep disorders.Highlights This was the first transcription‐neuroimaging study to demonstrate that multitrajectory neuroplasticity in neural circuits was induced via neuronavigated rTMS, which was associated with complex gene expression in AD‐spectrum patients with sleep disorders. The interactions between sleep quality and neuronavigated rTMS were coupled with multiple gene pathways and improvements in episodic memory. The present strategy for integrating neuroimaging, rTMS intervention, and genetic data provide a new approach to comprehending the biological mechanisms involved in AD.

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Abnormal brain iron accumulation in obstructive sleep apnea: A quantitative MRI study in the HypnoLaus cohort

Cited by 9 publications

References 54 publications

Ferroptosis-related genes are considered as potential targets for CPAP treatment of obstructive sleep apnea

Ferroptosis-related genes are considered as potential targets for CPAP treatment of obstructive sleep apnea

Corrigendum

Associations between the multitrajectory neuroplasticity of neuronavigated rTMS‐mediated angular gyrus networks and brain gene expression in AD spectrum patients with sleep disorders

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