Abnormal cerebellar volume in acute and remitted major depression

Depping, Malte S.; Wolf, Nadine D.; Vasić, Nenad; Sambataro, Fabio; Hirjak, Dušan; Thomann, Philipp A.

doi:10.1016/j.pnpbp.2016.06.005

Cited by 38 publications

(30 citation statements)

References 51 publications

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“…Similar to studies of AN 9, 11 and depression, 13 this approach of assessing brain structure in individuals ill and remitted from a given disorder permits understanding of whether CT may be a trait versus state marker of that disorder. Examining the effects of between- versus within-subject variations in CT on the frequency of binge-eating and purging behaviors is a novel approach, permitting assessment of CT in frontal regions as trait or state markers of BN symptoms.…”

Section: Discussionmentioning

confidence: 99%

“…Many studies have attempted to identify trait and state markers of a range of psychiatric disorders, including anorexia nervosa (AN), 9–12 depression, 13 bipolar disorder, 14 and schizophrenia. 15 A trait marker of a disorder is typically conceptualized in these studies as a characteristic that distinguishes an individual with a disorder from healthy controls, is present before and predicts disorder onset, persists following total or partial remission, and is present in individuals with subclinical profiles.…”

Section: Introductionmentioning

confidence: 99%

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Reduced Inferior and Orbital Frontal Thickness in Adolescent Bulimia Nervosa Persists Over Two-Year Follow-Up

Cyr

Kopala‐Sibley

Lee

et al. 2017

Journal of the American Academy of Child & Adolescent Psych

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Objective Cross-sectional data suggest functional and anatomical disturbances in inferior and orbital frontal regions in bulimia nervosa (BN). Using longitudinal data, we investigated whether reduced cortical thickness (CT) in these regions arises early and persists over adolescence in BN, independent of symptom remission, and whether CT reductions are markers of BN symptoms. Method Thirty-three adolescent females with BN symptoms (BN or other specified feeding or eating disorder) and 28 healthy adolescents participated in this study. Anatomical magnetic resonance imaging and clinical data were acquired at three time points within 2-year intervals over adolescence with 31% average attrition between assessments. Using a region-of-interest approach, we assessed group differences in CT at baseline and over time, and tested whether between- and within-subject variations in CT were associated with the frequency of BN symptoms. Results Reduced CT in right inferior frontal gyrus persisted over adolescence in BN compared to healthy adolescents, even in those who achieved full or partial remission. Within the BN group, between-subject variations in CT in inferior and orbital frontal regions were inversely associated with specific BN symptoms, suggesting, on average over time, greater CT reductions in those with more frequent BN symptoms. Conclusion Reduced CT in inferior frontal regions may contribute to illness persistence into adulthood. Reductions in the thickness of inferior and orbital frontal regions may be markers of specific BN symptoms. Since our sample size precluded correcting for multiple comparisons, these findings should be replicated in a larger sample. Future study of functional changes in associated fronto-striatal circuits could identify potential circuit-based intervention targets.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Reduced Inferior and Orbital Frontal Thickness in Adolescent Bulimia Nervosa Persists Over Two-Year Follow-Up

Cyr

Kopala‐Sibley

Lee

et al. 2017

Journal of the American Academy of Child & Adolescent Psych

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“…The circuits that connect the cerebellum to the cerebral cortices and paralimbic regions have been identified (Schmahmann, Weilburg, & Sherman, 2007;Stoodley & Schmahmann, 2009 and WM, particularly in the posterior lobules of the cerebellum (VI and VII; Baldaçara et al, 2008;Grieve et al, 2013). Recently, a study by Malte revealed (Depping et al, 2016(Depping et al, , 2017 that patients with an acute MDD episode have a higher volume in Cerebellar lobule IX, Cerebellar lobule VIII and Cerebellar lobule VIIb than HCs. However, research studies regarding the changes in the cerebellar volume and emotional memory in patients with depression remain scarce.…”

Section: Discussionmentioning

confidence: 99%

“…Lobule VII includes the vermis at the midline and the hemispheric portions of lobules VIIA (Crus I and Crus II) and VIIB. Recently, studies by Depping et al (2016Depping et al ( , 2017 have shown an increased GM volume in lobules VIIA and IX in individuals with MDD. Schutter, Koolschijn, Peper, and Crone (2012) demonstrated that the posterior lobules of the cerebellum are significantly involved in processes that are associated with cognitive and emotional functions.…”

Section: Introductionmentioning

confidence: 99%

Relationship between cerebellar structure and emotional memory in depression

Liu

et al. 2017

Brain and Behavior

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BackgroundA few studies have been conducted on the relationship between cerebellar volume and emotional memory or clinical severity in major depressive disorder (MDD). In this study, we aimed to compare the volume and density of the cerebellar gray matter (GM) in patients with MDD and in healthy controls (HCs) and explore the association between these cerebellar parameters and measurements of emotional memory and clinical severity.MethodVoxel‐based morphometry (VBM) and Individual Brain Atlases using Statistical Parametric Mapping (IBASPM) were used to assess GM density and volume in the cerebellum, respectively, in patients with MDD and the HCs. Indicators of emotional memory performance were measured, including the hit rate (HR), rate of false alarm (FA), precision (Pr = HR − FA) and emotional memory enhancement [∆Pr = Pr(emotion) − Pr(neutral)] values. Beck Depression Inventory (BDI) scores were used to measure the severity of depression.ResultsIn the patients with MDD, the GM density was decreased in three cerebellar cortical regions and increased in three cerebellar cortical regions (p < .005). The GM volumes in eight cerebellar cortical regions were significantly smaller in the patients with MDD than in the HC subjects (p < .05). In the patients with MDD, the GM volume was correlated with the ∆Pr (p < .05) in two cerebellar cortical regions. The BDI scores were significantly correlated with the relative GM densities (p < .05) in 5 cerebellar cortical regions, and the GM volumes in 13 cerebellar cortical regions were correlated with the BDI scores in patients with MDD.ConclusionsEmotional memory and the severity of depressive symptoms are associated with structural changes in both the posterior and anterior GM regions in the cerebellum in patients with MDD. These findings could be useful for improving our understanding of the neurobiological mechanisms underlying emotional memory and explaining the abnormalities of the neural correlates that are associated with MDD.

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“…Structural and functional changes of non-motor cerebellar regions in patients with depression have been subject to several MRI studies: Cerebellar connectivity has been investigated by six studies ( 24 – 29 ), cerebellar resting-state blood flow has been studied by one study ( 30 ), and cerebellum-optimized structural data analysis have been applied by two investigations ( 31 , 32 ). Task-based imaging studies of the cerebellum in depressed patients are lacking at present.…”

Section: Abnormal Cerebellar Structure and Function In Patients With mentioning

confidence: 99%

Cerebellar Contributions to Major Depression

et al. 2018

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Extending beyond the motor domain, the cerebellum is involved in various aspects of cognition and affect. Multidisciplinary evidence has demonstrated topographic organization of higher-order cognitive functions within the cerebellum. We here review recent neuroimaging research that indicates cerebellar contributions to major depressive disorder (MDD). At the structural level, increased volume of lobule IX has been demonstrated in MDD patients, independent of acute or remitted disease state. Successful treatment with electroconvulsive therapy has been associated with increased lobule VIIA volume in depressed patients. At the functional level, connectivity analyses have shown reduced cerebro-cerebellar coupling of lobules VI and VIIA/B with prefrontal, posterior parietal, and limbic regions in patients with MDD. As a limitation, most of this evidence is based on smaller patient samples with incomplete phenotypic and neuropsychological characterization and with heterogenous medication. Some studies did not apply cerebellum-optimized data analysis protocols. Taken together, MDD pathophysiology affects distinct subregions of the cerebellum that communicate with cortical networks subserving cognitive and self-referential processing. This mini-review synthesizes research evidence from cerebellar structural and functional neuroimaging in depression, and provides future perspectives for neuroimaging of cerebellar contributions to MDD.

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Abnormal cerebellar volume in acute and remitted major depression

Cited by 38 publications

References 51 publications

Reduced Inferior and Orbital Frontal Thickness in Adolescent Bulimia Nervosa Persists Over Two-Year Follow-Up

Reduced Inferior and Orbital Frontal Thickness in Adolescent Bulimia Nervosa Persists Over Two-Year Follow-Up

Relationship between cerebellar structure and emotional memory in depression

Cerebellar Contributions to Major Depression

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