Abnormal changes of plasma acute phase proteins in schizophrenia and the relation between schizophrenia and haptoglobin (Hp) gene

Wan, Chunling; La, Yune; Zhu, Hui; Yang, Yumei; Jiang, Lei; Chen, Youxing; Gao, Feng; Li, H.; Sang, Hong; Hao, Xinming; Zhang, G.; He, Lin

doi:10.1007/s00726-005-0292-8

Cited by 57 publications

(60 citation statements)

References 43 publications

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“…In a study focused on detecting schizophrenia-related changes of plasma proteins, Wan et al (169) used proteomic technology to examine the relation between schizophrenia and HP genotype. The authors investigated plasma proteins from schizophrenic subjects and healthy controls by two-dimensional gel electrophoresis in combination with mass spectrometry.…”

Section: Diseases Of the Nervous Systemmentioning

confidence: 99%

Zonulin and Its Regulation of Intestinal Barrier Function: The Biological Door to Inflammation, Autoimmunity, and Cancer

Fasano

2011

Physiological Reviews

789

633

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The primary functions of the gastrointestinal tract have traditionally been perceived to be limited to the digestion and absorption of nutrients and to electrolytes and water homeostasis. A more attentive analysis of the anatomic and functional arrangement of the gastrointestinal tract, however, suggests that another extremely important function of this organ is its ability to regulate the trafficking of macromolecules between the environment and the host through a barrier mechanism. Together with the gut-associated lymphoid tissue and the neuroendocrine network, the intestinal epithelial barrier, with its intercellular tight junctions, controls the equilibrium between tolerance and immunity to non-self antigens. Zonulin is the only physiological modulator of intercellular tight junctions described so far that is involved in trafficking of macromolecules and, therefore, in tolerance/immune response balance. When the finely tuned zonulin pathway is deregulated in genetically susceptible individuals, both intestinal and extraintestinal autoimmune, inflammatory, and neoplastic disorders can occur. This new paradigm subverts traditional theories underlying the development of these diseases and suggests that these processes can be arrested if the interplay between genes and environmental triggers is prevented by reestablishing the zonulin-dependent intestinal barrier function. This review is timely given the increased interest in the role of a “leaky gut” in the pathogenesis of several pathological conditions targeting both the intestine and extraintestinal organs.

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Section: Diseases Of the Nervous Systemmentioning

confidence: 99%

Zonulin and Its Regulation of Intestinal Barrier Function: The Biological Door to Inflammation, Autoimmunity, and Cancer

Fasano

2011

Physiological Reviews

789

633

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“…Wan, et al reported that the expression of serum amyloid P-component was significantly higher in the plasma of patients with schizophrenia in comparison with that of healthy controls [22]. Alterations in immune response may be an important component in the etiopathogenesis of schizophrenia.…”

Section: Serum Proteome Analysis Of Catatoniamentioning

confidence: 99%

“…It means that retinol binding protein has negative effects in transferring vitamin A from maternal liver storage sites to the placenta and is relation to avoid MAC disease [29]. In 2006, Wan, et al determined the levels of retinol binding protein, no statistical difference was found at gene expression level of schizophrenic patients in comparison with that of healthy controls [22]. Chen and his colleagues (2011) observed schizophrenic patients with metabolic syndrome in higher RBP4 and lower total adiponectin and high molecular weight adiponectin levels.…”

Section: Serum Proteome Analysis Of Catatoniamentioning

confidence: 99%

Serum Proteome Analysis of Catatonia

Huang¹,

Lo²,

Lin³

et al. 2017

Neuropsychiatry

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The exact mechanism of catatonia remains a mystery. We tried to investigate the serum biomarkers for patients with catatonia before and after successful treatment using proteomic analysis. During a three-year period, nine patients with schizophrenia who experienced catatonia and nine healthy controls were recruited. 5 ml of venous blood were collected before (acute phase) and after treatment (recovery phase) of catatonia, relieved by intramuscular lorazepam injection. The serum proteomes of acute and recovery phase were compared using two-dimensional polyacrylamide gel electrophoresis (2D-PAGE), combined with matrixassisted laser desorption ionization (MALDI)-time-of-flight (TOF) TOF mass spectrometry (MS). The findings were then validated with enzyme-linked immunosorbent assay (ELISA) by comparing data of patients and healthy controls. Ten differentially expressed protein spots were identified comparing serum proteome profiles of acute phase and recovery phase of catatonia from 2D PAGE. Alpha-2-HS-glycoprotein (AHSG), plasma retinol-binding protein (RBP4) and serum amyloid P component (APCS) may be potential disease-associated biomarkers for catatonia. In the validation phase, those serum proteins were measured in serum of both acute and recovery phase as well as healthy controls with ELISA. Mann-Whitney U-test showed that patients with catatonia in acute phase (p = 0.006) and recovery phase (p = 0.019) both had significantly higher APCS levels than healthy controls. Using ANCOVA with age adjustment, patients with catatonia in acute phase also had significantly higher APCS level than healthy controls (p = 0.048). Our investigation provided a proteomic study in biomarker research of catatonia. APCS might be an important biomaker for the psychopathology in catatonia of schizophrenia. In future, a larger of sample size will be needed to prove these results.

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“…An upregulation of APP genes has been found in schizophrenia, especially in the prefrontal cortex, and that that these genes overlap in the schizophrenia susceptibility loci. It has been suggested that acute phase reaction may be an aetiological agent in the pathophysiology of schizophrenia, but not just an accompanying symptom (186)(187)(188).…”

Section: The Immunological Markersmentioning

confidence: 99%