Abnormal development of B cells and B cell progenitors in autoimmune (NZB × NZW)F1 mice

Riley, Richard L.; Kruger, Mark G.; Riley, Esther A.

doi:10.1016/0090-1229(89)90035-4

Cited by 5 publications

(1 citation statement)

References 28 publications

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“…Previous studies have shown that the development of B-cell precursors is abnormal in old NZB mice and in the BWF1 (NZB×NZW F1) strains [3,13,14] and that the numbers of detectable BM pre-B cells and immature B cells decline in an age-dependent manner. It has been reported that this lineage-specific dysfunction progresses with age and eventually affects both pre-B and pro-B cell populations [5].…”

Section: Discussionmentioning

confidence: 99%

Age‐Related Alterations in the Lymphohematopoietic and B‐Lineage Precursor Populations in NZB Mice

et al. 2002

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Significant disturbances in B lineage populations of New Zealand Black (NZB) mice have been reported, both with respect to their phenotypes as well as to their function. Notably, there is a profound age-dependent decrease in B-cell precursors in this strain of lupus prone mice. In efforts to characterize the impact of this disturbance in disease, we performed an intensive phenotypic and B-cell population analysis in young and old NZB mice. Our results revealed that there was a significant age-dependent decrease in B cell precursors at all levels of the B-cell-lineage developmental pathway. Analysis of the proliferative capacity of these cell populations showed a comparative decrease in cycling activity in the B-celllineage populations of old NZB mice. Furthermore, these cell subsets were much more susceptible to spontaneous apoptosis when compared with similar populations from age-matched BALB/c or young NZB mice. Since the frequency of cells that express the interleukin-7 receptor (IL-7R) declines as NZB mice age, we hypothesize that impairment of IL-7R signal transduction pathways could contribute to severe perturbations of B-cell function in aged NZB mice.

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Section: Discussionmentioning

confidence: 99%

Age‐Related Alterations in the Lymphohematopoietic and B‐Lineage Precursor Populations in NZB Mice

et al. 2002

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B cell precursors are decreased in senescent mice, but retain normal mitotic activity in vivo and in vitro

Riley

Kruger

Elia

1991

Clinical Immunology and Immunopathology

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Bone marrow stromal cells modulate both kappa light chain and Ly1 antigen expression on Ly1+ pre-B cell lines in vitro

Kruger

Riley

et al. 1990

Blood

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Murine Ly1+ pre-B cell lines, including 70Z/3 and three pre-B cell lines derived from long-term bone marrow cultures, exhibited selective adherence to bone marrow stromal cells. In contrast, splenic B cells, the A20 B-cell lymphoma, and four Ly1- B cell lines derived from long- term bone marrow cultures failed to adhere substiantially to bone marrow cultures failed to adhere substiantially to bone marrow stroma. Ly1+ pre-B cell lines were induced to express kappa light chains by exposure to either lipopolysaccharide (LPS), recombinant interleukin-1 (IL-1), or stromal cells. However, induction of kappa light chains failed to prevent pre-B cell adherence to stromal cells. Supernatants derived from primary bone marrow stromal cells decreased Ly1 expression on the Ly1+ pre-B cell lines. These experiments suggest that (1) expression of immunoglobulin light chains by developing Ly1+ pre-B cells is mediated by bone marrow stromal cells; (2) loss of specific adherence to stroma is progressive and occurs post-light chain induction; and (3) soluble products of stromal cells may downregulate expression of surface Ly1 on otherwise Ly1+ pre-B cells. The importance of these observations to the development of both the Ly1- and Ly1+ B cell lineages in the mouse is discussed.

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Abnormal development of B cells and B cell progenitors in autoimmune (NZB × NZW)F1 mice

Cited by 5 publications

References 28 publications

Age‐Related Alterations in the Lymphohematopoietic and B‐Lineage Precursor Populations in NZB Mice

Age‐Related Alterations in the Lymphohematopoietic and B‐Lineage Precursor Populations in NZB Mice

B cell precursors are decreased in senescent mice, but retain normal mitotic activity in vivo and in vitro

Bone marrow stromal cells modulate both kappa light chain and Ly1 antigen expression on Ly1+ pre-B cell lines in vitro

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